Probable E3 ubiquitin-protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3gene.[1][2] The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1-like domain (RLD). It binds ubiquitin and hPLIC-1/2 via its HECT domain. Alternatively spiced transcript variants encoding multiple isoforms have been observed, and mutations in this gene have been linked to colorectal and gastric carcinomas. The protein is localized in the cytosol and vesicular-like structures containing β-COP, ARF, and Rab5. Since HERC3 can itself be ubiquitinated and degraded by the proteasome, it likely has roles in both vesicular traffic and ubiquitin-dependent processes.[3][4][5]
HERC3
Identifiers
Symbol
HERC3
Alt. names
HECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, KIAA0032
^Garcia-Gonzalo FR, Rosa JL (Aug 2005). "The HERC proteins: functional and evolutionary insights". Cell Mol Life Sci. 62 (16): 1826–1838. doi:10.1007/s00018-005-5119-y. PMID 15968461. S2CID 23391275.
^Sánchez-Tena S, Cubillos-Rojas M, Schneider T, Rosa JL (May 2016). "Functional and pathological relevance of HERC family proteins: a decade later". Cell Mol Life Sci. 73 (10): 18955–1968. doi:10.1007/s00018-016-2139-8. PMID 26801221. S2CID 7457614.
^Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell Mol Life Sci. 65 (13): 2105–2117. doi:10.1007/s00018-008-8148-5. PMID 18535780. S2CID 6897759.
^Cruz C, Ventura F, Bartrons R, Rosa JL (Jan 2001). "HERC3 binding to and regulation by ubiquitin". FEBS Lett. 488 (1–2): 74–80. doi:10.1016/S0014-5793(00)02371-1. PMID 11163799. S2CID 20091003.
Hochrainer K, Pejanovic N, Olaseun VA, Zhang S, Iadecola C, Anrather J (16 Nov 2015). "The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation". Nucleic Acids Res. 43 (20): 9889–9904. doi:10.1093/nar/gkv1064. PMC4787756. PMID 26476452.
Cowley M, Wood AJ, Böhm S, Schulz R, Oakey RJ (Oct 2012). "Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus". Nucleic Acids Res. 40 (18): 8917–8926. doi:10.1093/nar/gks654. PMC3467052. PMID 22790983.
Yoo NJ, Park SJ, Lee SH (Dec 2011). "Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability". Pathology. 43 (7): 753–755. doi:10.1097/PAT.0b013e32834c7e78. PMID 22124266.
Scheffner M, Staub O (22 Nov 2007). "HECT E3s and human disease". BMC Biochem. 8 ((Suppl 1):S6): S6. doi:10.1186/1471-2091-8-S1-S6. PMC2106370. PMID 18047743.
Cruz C, Nadal M, Ventura F, Bartrons R, Estivill X, Rosa JL (1999). "The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 263–264. doi:10.1159/000015442. PMID 10702688. S2CID 42602080.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
herc3, probable, ubiquitin, protein, ligase, enzyme, that, humans, encoded, gene, gene, member, herc, family, ubiquitin, ligases, encodes, protein, with, hect, domain, rcc1, like, domain, binds, ubiquitin, hplic, hect, domain, alternatively, spiced, transcript. Probable E3 ubiquitin protein ligase HERC3 is an enzyme that in humans is encoded by the HERC3 gene 1 2 The gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and an RCC1 like domain RLD It binds ubiquitin and hPLIC 1 2 via its HECT domain Alternatively spiced transcript variants encoding multiple isoforms have been observed and mutations in this gene have been linked to colorectal and gastric carcinomas The protein is localized in the cytosol and vesicular like structures containing b COP ARF and Rab5 Since HERC3 can itself be ubiquitinated and degraded by the proteasome it likely has roles in both vesicular traffic and ubiquitin dependent processes 3 4 5 HERC3IdentifiersSymbolHERC3Alt namesHECT domain and RCC1 like domain containing protein 3 HECT type E3 ubiquitin transferase HERC3 KIAA0032NCBI gene8916HGNC4876OMIM605200PDBQ15034RefSeqNM 001271602 NM 001318505 NM 014606 NM 001271602 NM 001318505UniProtQ15034Other dataEC number2 3 2 26LocusChr 4 q22 1 88 592 422 88 709 302Search forStructuresSwiss modelDomainsInterProReferences edit Garcia Gonzalo FR Rosa JL Aug 2005 The HERC proteins functional and evolutionary insights Cell Mol Life Sci 62 16 1826 1838 doi 10 1007 s00018 005 5119 y PMID 15968461 S2CID 23391275 Sanchez Tena S Cubillos Rojas M Schneider T Rosa JL May 2016 Functional and pathological relevance of HERC family proteins a decade later Cell Mol Life Sci 73 10 18955 1968 doi 10 1007 s00018 016 2139 8 PMID 26801221 S2CID 7457614 Hochrainer K Kroismayr R Baranyi U Binder BR Lipp J Jul 2008 Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B Cell Mol Life Sci 65 13 2105 2117 doi 10 1007 s00018 008 8148 5 PMID 18535780 S2CID 6897759 Cruz C Ventura F Bartrons R Rosa JL Jan 2001 HERC3 binding to and regulation by ubiquitin FEBS Lett 488 1 2 74 80 doi 10 1016 S0014 5793 00 02371 1 PMID 11163799 S2CID 20091003 Entrez Gene HERC3 Further reading editHochrainer K Pejanovic N Olaseun VA Zhang S Iadecola C Anrather J 16 Nov 2015 The ubiquitin ligase HERC3 attenuates NF kB dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation Nucleic Acids Res 43 20 9889 9904 doi 10 1093 nar gkv1064 PMC 4787756 PMID 26476452 Cowley M Wood AJ Bohm S Schulz R Oakey RJ Oct 2012 Epigenetic control of alternative mRNA processing at the imprinted Herc3 Nap1l5 locus Nucleic Acids Res 40 18 8917 8926 doi 10 1093 nar gks654 PMC 3467052 PMID 22790983 Yoo NJ Park SJ Lee SH Dec 2011 Frameshift mutations of ubiquitination related genes HERC2 HERC3 TRIP12 UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability Pathology 43 7 753 755 doi 10 1097 PAT 0b013e32834c7e78 PMID 22124266 Scheffner M Staub O 22 Nov 2007 HECT E3s and human disease BMC Biochem 8 Suppl 1 S6 S6 doi 10 1186 1471 2091 8 S1 S6 PMC 2106370 PMID 18047743 Cruz C Nadal M Ventura F Bartrons R Estivill X Rosa JL 1999 The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization Cytogenet Cell Genet 87 3 4 263 264 doi 10 1159 000015442 PMID 10702688 S2CID 42602080 nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HERC3 amp oldid 1187730903, wikipedia, wiki, book, books, library,
