The compensation law of mortality (or late-life mortality convergence) states that the relative differences in death rates between different populations of the same biological species decrease with age, because the higher initial death rates in disadvantaged populations are compensated by lower pace of mortality increase with age. The age at which this imaginary (extrapolated) convergence of mortality trajectories takes place is named the "species-specific life span" (see Gavrilov and Gavrilova, 1979). For human beings, this human species-specific life span is close to 95 years (Gavrilov and Gavrilova, 1979; 1991).
Compensation law of mortality is a paradoxical empirical observation, and it represents a challenge for methods of survival analysis based on proportionality assumption (proportional hazard models). The compensation law of mortality also represents a great challenge for many theories of aging and mortality, which usually fail to explain this phenomenon. On the other hand, the compensation law follows directly from reliability theory, when the compared systems have different initial levels of redundancy.
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Gavrilov LA, Gavrilova NS. "" In: Masoro E.J. & Austad S.N.. (eds.): Handbook of the Biology of Aging, Sixth Edition. Academic Press. San Diego, CA, USA, 2006, 3-42. ISBN0-12-088387-2
Gavrilov LA, Gavrilova NS. Why We Fall Apart. Engineering's Reliability Theory Explains Human Aging. IEEE Spectrum, 2004, 41(9): 30–35.
Gavrilov L.A., Gavrilova N.S. "The quest for a general theory of aging and longevity". Science's SAGE KE (Science of Aging Knowledge Environment) for 16 July 2003; Vol. 2003, No. 28, 1–10. https://www.science.org/loi/sageke, PMID 12867663
Gavrilov L.A., Gavrilova N.S. The reliability theory of aging and longevity. Journal of Theoretical Biology, 2001, 213(4): 527–545. doi:10.1006/jtbi.2001.2430 PMID 11742523
Leonid A. Gavrilov & Natalia S. Gavrilova (1991), The Biology of Life Span: A Quantitative Approach. New York: Harwood Academic Publisher, ISBN3-7186-4983-7
Gavrilov, L.A., Gavrilova, N.S. "Determination of species length of life". Doklady Akademii Nauk SSSR, 1979, 246(2): 465–469. English translation by Plenum Publ Corp: pp. 905–908. PMID 111909
Gavrilov, L.A. "A mathematical model of the aging of animals". Doklady Akademii Nauk SSSR, 1978, 238(2): 490–492. English translation by Plenum Publ Corp: pp. 53–55. PMID 624242
Gavrilov, L.A., Gavrilova, N.S., Yaguzhinsky, L.S. "The main regularities of animal aging and death viewed in terms of reliability theory". J. General Biology [Zhurnal Obschey Biologii], 1978, 39(5): 734–742. PMID 716614
December 20, 2023
compensation, mortality, compensation, mortality, late, life, mortality, convergence, states, that, relative, differences, death, rates, between, different, populations, same, biological, species, decrease, with, because, higher, initial, death, rates, disadva. The compensation law of mortality or late life mortality convergence states that the relative differences in death rates between different populations of the same biological species decrease with age because the higher initial death rates in disadvantaged populations are compensated by lower pace of mortality increase with age The age at which this imaginary extrapolated convergence of mortality trajectories takes place is named the species specific life span see Gavrilov and Gavrilova 1979 For human beings this human species specific life span is close to 95 years Gavrilov and Gavrilova 1979 1991 Compensation law of mortality is a paradoxical empirical observation and it represents a challenge for methods of survival analysis based on proportionality assumption proportional hazard models The compensation law of mortality also represents a great challenge for many theories of aging and mortality which usually fail to explain this phenomenon On the other hand the compensation law follows directly from reliability theory when the compared systems have different initial levels of redundancy See also edit nbsp Look up compensation law of mortality in Wiktionary the free dictionary Ageing Biodemography of human longevity Biogerontology Demography Mortality Reliability theory of aging and longevityReferences editGavrilov LA Gavrilova NS Reliability Theory of Aging and Longevity In Masoro E J amp Austad S N eds Handbook of the Biology of Aging Sixth Edition Academic Press San Diego CA USA 2006 3 42 ISBN 0 12 088387 2 Gavrilov LA Gavrilova NS Why We Fall Apart Engineering s Reliability Theory Explains Human Aging IEEE Spectrum 2004 41 9 30 35 Gavrilov L A Gavrilova N S The quest for a general theory of aging and longevity Science s SAGE KE Science of Aging Knowledge Environment for 16 July 2003 Vol 2003 No 28 1 10 https www science org loi sageke PMID 12867663 Gavrilov L A Gavrilova N S The reliability theory of aging and longevity Journal of Theoretical Biology 2001 213 4 527 545 doi 10 1006 jtbi 2001 2430 PMID 11742523 Leonid A Gavrilov amp Natalia S Gavrilova 1991 The Biology of Life Span A Quantitative Approach New York Harwood Academic Publisher ISBN 3 7186 4983 7 Gavrilov L A Gavrilova N S Determination of species length of life Doklady Akademii Nauk SSSR 1979 246 2 465 469 English translation by Plenum Publ Corp pp 905 908 PMID 111909 Gavrilov L A A mathematical model of the aging of animals Doklady Akademii Nauk SSSR 1978 238 2 490 492 English translation by Plenum Publ Corp pp 53 55 PMID 624242 Gavrilov L A Gavrilova N S Yaguzhinsky L S The main regularities of animal aging and death viewed in terms of reliability theory J General Biology Zhurnal Obschey Biologii 1978 39 5 734 742 PMID 716614 Retrieved from https en wikipedia org w index php title Compensation law of mortality amp oldid 1139231983, wikipedia, wiki, book, books, library,
