Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, and urticaria. There are potential interactions with other anticholinergics, CNS depressants, and alcohol.[3]
Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[5] and its safety and efficacy data are limited. It was formerly sold over-the-counter in the United States under the trade name Ulo, as a syrup with a dosage of 25 mg/5 mL.[6] It is now marketed under the brand name of Ninjacof in the U.S.
It is marketed in Canada under the trade name Ulone. GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States.[7]
It is sold in Japan as an over-the-counter drug under the name Coldrin.[8] It has been marketed in Germany as Pectolitan and in Spain as Gentos.[9]
^Martín, Alfonso Velasco (2004). "Tratamiento sintomático de la tos y del resfriado común". Farmacología clínica y terapéutica médica. p. 260. ISBN9788448604271.
^"Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
^Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 29. ISBN0-8103-7177-4.
^Klein M, Musacchio JM (October 10, 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–156.
^"Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.
^Approved Drug Products with Therapeutic Equivalence Evaluations, March 2020 Edition (Report). Food and Drug Administration. March 20, 2020. Retrieved April 7, 2021.
^"How Odes Mitchell Built a Pharmaceutical Empire". D Magazine. Retrieved 2020-11-25.
^"クロフェダノール:コルドリン" [Clofedanol: Coldrin]. Medicine 110 (in Japanese). Retrieved March 22, 2021.
^Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 29. ISBN0-8103-7177-4.
clofedanol, chlophedianol, sold, under, brand, name, ninjacof, among, others, centrally, acting, cough, suppressant, used, treatment, cough, local, anesthetic, antispasmodic, antihistamine, properties, have, anticholinergic, effects, high, doses, clinical, dat. Clofedanol INN or chlophedianol BAN sold under the brand name Ninjacof among others is a centrally acting cough suppressant used in the treatment of dry cough Clofedanol has local anesthetic antispasmodic and antihistamine properties 1 and may have anticholinergic effects at high doses 2 ClofedanolClinical dataTrade namesColdrin Gentos Pectolitan Ulo UloneAHFS Drugs comMicromedex Detailed Consumer InformationRoutes ofadministrationOralATC codeR05DB10 WHO Legal statusLegal statusUS OTCIdentifiersIUPAC name 1 2 chlorophenyl 3 dimethylamino 1 phenyl propan 1 olCAS Number791 35 5 YPubChem CID2795IUPHAR BPS7324DrugBankDB04837 YChemSpider2693 YUNII42C50P12APKEGGD07721 YChEMBLChEMBL1201313 NCompTox Dashboard EPA DTXSID4022789ECHA InfoCard100 011 219Chemical and physical dataFormulaC 17H 20Cl N OMolar mass289 80 g mol 13D model JSmol Interactive imageSMILES Clc1ccccc1C O c2ccccc2 CCN C CInChI InChI 1S C17H20ClNO c1 19 2 13 12 17 20 14 8 4 3 5 9 14 15 10 6 7 11 16 15 18 h3 11 20H 12 13H2 1 2H3 YKey WRCHFMBCVFFYEQ UHFFFAOYSA N Y N Y what is this verify Contents 1 Side effects 2 Pharmacology 3 Society and culture 4 See also 5 ReferencesSide effects editAdverse effects may include irritability drowsiness nightmares vertigo nausea or vomiting visual disturbances or hallucinations and urticaria There are potential interactions with other anticholinergics CNS depressants and alcohol 3 Pharmacology editUnlike many other antitussive drugs such as dextromethorphan it binds poorly to the sigma 1 receptor 4 Society and culture editChlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process 5 and its safety and efficacy data are limited It was formerly sold over the counter in the United States under the trade name Ulo as a syrup with a dosage of 25 mg 5 mL 6 It is now marketed under the brand name of Ninjacof in the U S It is marketed in Canada under the trade name Ulone GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States 7 It is sold in Japan as an over the counter drug under the name Coldrin 8 It has been marketed in Germany as Pectolitan and in Spain as Gentos 9 See also editAzacyclonolReferences edit Martin Alfonso Velasco 2004 Tratamiento sintomatico de la tos y del resfriado comun Farmacologia clinica y terapeutica medica p 260 ISBN 9788448604271 Clofedanol in French BIAM 1998 07 24 Retrieved 2007 04 15 Schlesser JL 1991 Drugs Available Abroad 1st Edition Derwent Publications Ltd p 29 ISBN 0 8103 7177 4 Klein M Musacchio JM October 10 1988 Dextromethorphan binding sites in the guinea pig brain Cellular and Molecular Neurobiology 8 2 149 156 Department of Health and Human Services Food and Drug Administration 21 CFR Parts 310 341 and 369 Docket No 76N 052T Cold cough allergy bronchodilator and antiasthmatic drug products for over the counter human use final monograph for OTC antitussive drug products Federal Register 1987 52 155 30042 57 PDF FDA gov 1987 08 12 Approved Drug Products with Therapeutic Equivalence Evaluations March 2020 Edition Report Food and Drug Administration March 20 2020 Retrieved April 7 2021 How Odes Mitchell Built a Pharmaceutical Empire D Magazine Retrieved 2020 11 25 クロフェダノール コルドリン Clofedanol Coldrin Medicine 110 in Japanese Retrieved March 22 2021 Schlesser JL 1991 Drugs Available Abroad 1st Edition Derwent Publications Ltd p 29 ISBN 0 8103 7177 4 nbsp This drug article relating to the respiratory system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Clofedanol amp oldid 1162129275, wikipedia, wiki, book, books, library,
