F11 receptor

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene.^[5][6][7] It has also been designated as CD321 (cluster of differentiation 321).

F11R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NBQ, 3EOY, 3TSZ, 4ODB
Identifiers
Aliases	F11R, F11r, 9130004G24, AA638916, ESTM33, JAM, JAM-1, JAM-A, Jcam, Jcam1, Ly106, CD321, JAM1, JAMA, KAT, PAM-1, F11 receptor
External IDs	OMIM: 605721 MGI: 1321398 HomoloGene: 14255 GeneCards: F11R
Gene location (Human) Chr. Chromosome 1 (human)^[1] Band 1q23.3 Start 160,995,211 bp^[1] End 161,021,343 bp^[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)^[2] Band 1 H3|1 79.43 cM Start 171,265,103 bp^[2] End 171,292,171 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung rectum islet of Langerhans upper lobe of left lung minor salivary gland gallbladder skin of abdomen left lobe of thyroid gland body of pancreas right uterine tube Top expressed in saccule otic placode corneal stroma left lung lobe epithelium of stomach large intestine colon left colon duodenum jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding virus receptor activity protein binding cadherin binding Cellular component integral component of membrane membrane cell-cell junction bicellular tight junction plasma membrane slit diaphragm extracellular exosome cytoplasmic vesicle cell junction Biological process regulation of actin cytoskeleton reorganization cell differentiation establishment of endothelial intestinal barrier epithelial cell differentiation actomyosin structure organization extracellular matrix organization regulation of membrane permeability regulation of cytokine production positive regulation of GTPase activity positive regulation of blood pressure cell adhesion negative regulation of GTPase activity bicellular tight junction assembly viral entry into host cell intestinal absorption response to radiation inflammatory response viral process transforming growth factor beta receptor signaling pathway leukocyte migration protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50848 16456 Ensembl ENSG00000158769 ENSMUSG00000038235 UniProt Q9Y624 O88792 RefSeq (mRNA) NM_016946 NM_144501 NM_144502 NM_144503 NM_144504 NM_001348091 NM_001382727 NM_001382730 NM_001382733 NM_001382734 NM_172647 RefSeq (protein) NP_058642 NP_001335020 NP_001369656 NP_001369659 NP_001369662 NP_001369663 NP_766235 Location (UCSC) Chr 1: 161 – 161.02 Mb Chr 1: 171.27 – 171.29 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.^[7]

Interactions

F11 receptor has been shown to interact with MLLT4,^[8] CASK^[8][9] and Tight junction protein 1.^[8][10]

References

1. GRCh38: Ensembl release 89: ENSG00000158769 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038235 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T (Jul 1999). "Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells". Journal of Immunology. 163 (2): 553–7. doi:10.4049/jimmunol.163.2.553. PMID 10395639. S2CID 255364609.
6. Naik UP, Ehrlich YH, Kornecki E (Aug 1995). "Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor". The Biochemical Journal. 310 ( Pt 1) (1): 155–62. doi:10.1042/bj3100155. PMC 1135867. PMID 7646439.
7. "Entrez Gene: F11R F11 receptor".
8. Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D (Sep 2000). "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". The Journal of Biological Chemistry. 275 (36): 27979–88. doi:10.1074/jbc.M002363200. PMID 10856295.
9. Martinez-Estrada OM, Villa A, Breviario F, Orsenigo F, Dejana E, Bazzoni G (Mar 2001). "Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells". The Journal of Biological Chemistry. 276 (12): 9291–6. doi:10.1074/jbc.M006991200. PMID 11120739.
10. Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". Journal of Cell Science. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.

Further reading

• Muller WA (Jun 2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends in Immunology. 24 (6): 327–34. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109.
• Bazzoni G (Oct 2003). "The JAM family of junctional adhesion molecules". Current Opinion in Cell Biology. 15 (5): 525–30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386.
• Naik UP, Eckfeld K (2004). "Junctional adhesion molecule 1 (JAM-1)". Journal of Biological Regulators and Homeostatic Agents. 17 (4): 341–7. PMID 15065765.
• Kornecki E, Walkowiak B, Naik UP, Ehrlich YH (Jun 1990). "Activation of human platelets by a stimulatory monoclonal antibody". The Journal of Biological Chemistry. 265 (17): 10042–8. doi:10.1016/S0021-9258(19)38776-9. PMID 2351647.
• Williams LA, Martin-Padura I, Dejana E, Hogg N, Simmons DL (Dec 1999). "Identification and characterisation of human Junctional Adhesion Molecule (JAM)". Molecular Immunology. 36 (17): 1175–88. doi:10.1016/S0161-5890(99)00122-4. PMID 10698320.
• Sobocka MB, Sobocki T, Banerjee P, Weiss C, Rushbrook JI, Norin AJ, Hartwig J, Salifu MO, Markell MS, Babinska A, Ehrlich YH, Kornecki E (Apr 2000). "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation". Blood. 95 (8): 2600–9. doi:10.1182/blood.V95.8.2600. PMID 10753840.
• Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA (Jul 2000). "Human junction adhesion molecule regulates tight junction resealing in epithelia". Journal of Cell Science. 113 ( Pt 13) (13): 2363–74. doi:10.1242/jcs.113.13.2363. PMID 10852816.
• Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D (Sep 2000). "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". The Journal of Biological Chemistry. 275 (36): 27979–88. doi:10.1074/jbc.M002363200. PMID 10856295.
• Bazzoni G, Martinez-Estrada OM, Orsenigo F, Cordenonsi M, Citi S, Dejana E (Jul 2000). "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin". The Journal of Biological Chemistry. 275 (27): 20520–6. doi:10.1074/jbc.M905251199. PMID 10877843.
• Gupta SK, Pillarisetti K, Ohlstein EH (Jul 2000). "Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages". IUBMB Life. 50 (1): 51–6. doi:10.1080/15216540050176593. PMID 11087121. S2CID 37733691.
• Martinez-Estrada OM, Villa A, Breviario F, Orsenigo F, Dejana E, Bazzoni G (Mar 2001). "Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells". The Journal of Biological Chemistry. 276 (12): 9291–6. doi:10.1074/jbc.M006991200. PMID 11120739.
• Naik UP, Naik MU, Eckfeld K, Martin-DeLeon P, Spychala J (Feb 2001). "Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody". Journal of Cell Science. 114 (Pt 3): 539–47. doi:10.1242/jcs.114.3.539. PMID 11171323.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS (Feb 2001). "Junction adhesion molecule is a receptor for reovirus". Cell. 104 (3): 441–51. doi:10.1016/S0092-8674(01)00231-8. PMID 11239401. S2CID 17095289.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (Jul 2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". The EMBO Journal. 20 (14): 3738–48. doi:10.1093/emboj/20.14.3738. PMC 125258. PMID 11447115.
• Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T, Tsukita S (Aug 2001). "Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions". The Journal of Cell Biology. 154 (3): 491–7. doi:10.1083/jcb.200103047. PMC 2196413. PMID 11489913.
• Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S (Jan 2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". The Journal of Biological Chemistry. 277 (1): 455–61. doi:10.1074/jbc.M109005200. hdl:2433/148697. PMID 11689568.

External links

• KDR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.