IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzesGTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.
Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.[2]
Referencesedit
^Prokaryotic+Initiation+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^D'Souza AR, Minczuk M (July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry. 62 (3): 309–320. doi:10.1042/EBC20170102. PMC6056719. PMID 30030363.
January 01, 1970
bacterial, initiation, factor, bacterial, initiation, factor, bacterial, initiation, factor, translation, initiation, factor, bacterial, likeidentifierssymbol, interproipr000178, binds, initiator, trna, controls, entry, trna, onto, ribosome, bound, binds, site. Bacterial initiation factor 2 is a bacterial initiation factor 1 Translation initiation factor IF 2 bacterial likeIdentifiersSymbol InterProIPR000178 IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome IF2 bound to GTP binds to the 30S P site After associating with the 30S subunit fMet tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site When the 50S subunit joins it hydrolyzes GTP to GDP and Pi causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form Human mitochondria use a nuclear encoded homolog MTIF2 for translation initiation 2 References edit Prokaryotic Initiation Factor 2 at the U S National Library of Medicine Medical Subject Headings MeSH D Souza AR Minczuk M July 2018 Mitochondrial transcription and translation overview Essays in Biochemistry 62 3 309 320 doi 10 1042 EBC20170102 PMC 6056719 PMID 30030363 Retrieved from https en wikipedia org w index php title Bacterial initiation factor 2 amp oldid 951715200, wikipedia, wiki, book, books, library,
