BMS-906024 is a drug with a benzodiazepine structure, developed by Bristol-Myers Squibb and disclosed at the spring 2013 American Chemical Society meeting in New Orleans to treat breast, lung, colon cancers and leukemia.[1] The drug works as a pan-Notch inhibitor. The structure is one of a set patented in 2012,[2] and is being studied in clinical trials.[3][4][5]
^Drahl C (2013). "Liveblogging First-Time Disclosures of Drug Structures from #ACSNOLA". Chemical and Engineering News. American Chemical Society.
^WO 2012129353, Quesnelle C, Kim SH, Lee F, Gavai A, "Bisfluoroalkyl-1,4-Benzodiazepinone Compounds", published 27 September 2012, assigned to Bristol-Myers Squibb Company
^Gavai AV, Quesnelle C, Norris D, Han WC, Gill P, Shan W, et al. (May 2015). "Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors". ACS Medicinal Chemistry Letters. 6 (5): 523–7. doi:10.1021/acsmedchemlett.5b00001. PMC4434460. PMID 26005526.
^Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, et al. (December 2017). "Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma". Molecular Cancer Therapeutics. 16 (12): 2759–2769. doi:10.1158/1535-7163.MCT-17-0439. PMC5716926. PMID 28978720.
^Sosa Iglesias V, Theys J, Groot AJ, Barbeau LM, Lemmens A, Yaromina A, et al. (2018). "Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells". Frontiers in Oncology. 8: 460. doi:10.3389/fonc.2018.00460. PMC6234899. PMID 30464927.
906024, drug, with, benzodiazepine, structure, developed, bristol, myers, squibb, disclosed, spring, 2013, american, chemical, society, meeting, orleans, treat, breast, lung, colon, cancers, leukemia, drug, works, notch, inhibitor, structure, patented, 2012, b. BMS 906024 is a drug with a benzodiazepine structure developed by Bristol Myers Squibb and disclosed at the spring 2013 American Chemical Society meeting in New Orleans to treat breast lung colon cancers and leukemia 1 The drug works as a pan Notch inhibitor The structure is one of a set patented in 2012 2 and is being studied in clinical trials 3 4 5 BMS 906024IdentifiersIUPAC name 2R 3S N 3S 1 Methyl 2 oxo 5 phenyl 2 3 dihydro 1H 1 4 benzodiazepin 3 yl 2 3 bis 3 3 3 trifluoropropyl succinamideCAS Number1401066 79 2PubChem CID66550890PubChem SID152143555ChemSpider28536138UNIIDRL23N424RCompTox Dashboard EPA DTXSID30161234Chemical and physical dataFormulaC 26H 26F 6N 4O 3Molar mass556 509 g mol 13D model JSmol Interactive imageSMILES CN1c2ccccc2C N C H C1 O NC O C H CCC F F F C H CCC F F F C O N c3ccccc3InChI InChI 1S C26H26F6N4O3 c1 36 19 10 6 5 9 18 19 20 15 7 3 2 4 8 15 34 22 24 36 39 35 23 38 17 12 14 26 30 31 32 16 21 33 37 11 13 25 27 28 29 h2 10 16 17 22H 11 14H2 1H3 H2 33 37 H 35 38 t16 17 22 m0 s1Key AYOUDDAETNMCBW GSHUGGBRSA NReferences Edit Drahl C 2013 Liveblogging First Time Disclosures of Drug Structures from ACSNOLA Chemical and Engineering News American Chemical Society WO 2012129353 Quesnelle C Kim SH Lee F Gavai A Bisfluoroalkyl 1 4 Benzodiazepinone Compounds published 27 September 2012 assigned to Bristol Myers Squibb Company Gavai AV Quesnelle C Norris D Han WC Gill P Shan W et al May 2015 Discovery of Clinical Candidate BMS 906024 A Potent Pan Notch Inhibitor for the Treatment of Leukemia and Solid Tumors ACS Medicinal Chemistry Letters 6 5 523 7 doi 10 1021 acsmedchemlett 5b00001 PMC 4434460 PMID 26005526 Morgan KM Fischer BS Lee FY Shah JJ Bertino JR Rosenfeld J et al December 2017 Gamma Secretase Inhibition by BMS 906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma Molecular Cancer Therapeutics 16 12 2759 2769 doi 10 1158 1535 7163 MCT 17 0439 PMC 5716926 PMID 28978720 Sosa Iglesias V Theys J Groot AJ Barbeau LM Lemmens A Yaromina A et al 2018 Synergistic Effects of NOTCH g Secretase Inhibition and Standard of Care Treatment Modalities in Non small Cell Lung Cancer Cells Frontiers in Oncology 8 460 doi 10 3389 fonc 2018 00460 PMC 6234899 PMID 30464927 This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title BMS 906024 amp oldid 1128408118, wikipedia, wiki, book, books, library,
