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Wikipedia

Rabies immunoglobulin

January 01, 1970

Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus.[10] It is used to prevent rabies following exposure.[10] It is given after the wound is cleaned with soap and water or povidone-iodine and is followed by a course of rabies vaccine.[10] It is given by injection into the site of the wound and into a muscle.[10] It is not needed in people who have been previously vaccinated against rabies.[11]

Rabies immunoglobulin
Clinical data
Trade namesImogam Rabies-HT, Kedrab, Hyperrab, others
AHFS/Drugs.comMonograph
Pregnancy
category
Routes of
administration		Intramuscular injection
ATC code
Legal status
Legal status
Identifiers
DrugBank
  • DB11603
ChemSpider
  • none
UNII
  • 95F619ATQ2

Common side effects include pain at the site of injection, fever, and headache.[10] Severe allergic reactions such as anaphylaxis may rarely occur.[12] Use during pregnancy is not known to harm the baby.[10] It works by binding to the rabies virus before it can enter nerve tissue.[10] After the virus has entered the central nervous system, rabies immunoglobulin is no longer useful.[10]

The use of rabies immunoglobulin in the form of blood serum dates from 1891.[13] Use became common within medicine in the 1950s.[14] It is on the World Health Organization's List of Essential Medicines.[15] Rabies immunoglobulin is expensive and hard to come by in the developing world.[16] In the United States it is estimated to be more than US$1,000.00 per dose.[17] It is made from the blood plasma of people or horses who have high levels of the antibody in their blood.[10][17] The horse version is less expensive but has a higher rate of side effects.[17][14]

Medical uses edit

Rabies immunoglobulin (RIG) is indicated for the passive, transient post-exposure prophylaxis of rabies infection, when given immediately after contact with a rabid or possibly rabid animal and in combination with a rabies vaccine.[18][19][1]

Society and culture edit

Names edit

There are three versions of rabies immunoglobulin licensed and available in the US.[20] Imogam Rabies-HT is produced by Sanofi Pasteur.[6] Kedrab is produced by Kedrion Biopharma.[18][7] Hyperrab is produced by Grifols.[8]

Imogam Rabies-HT and Kedrab have a nominal potency of 150 IU/mL while Hyperrab has a nominal potency of 300 IU/mL and requires smaller dosing. All three versions are used for post-exposure[21] and indicate local infusion at the wound site with additional amount intramuscularly at a site distant from vaccine administration.[22]

Kamrab is approved for medical use in Australia.[1]

References edit

  1. ^ a b c d "Kamrab". Therapeutic Goods Administration (TGA). 23 August 2021. Retrieved 10 September 2021.
  2. ^ "Kamrab PI". Health Canada. 25 April 2012. Retrieved 10 September 2021.
  3. ^ "Imogam PI". Health Canada. 25 April 2012. Retrieved 10 September 2021.
  4. ^ "Hyperrab S/D PI". Health Canada. 25 April 2012. Retrieved 10 September 2021.
  5. ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
  6. ^ a b "Imogam Rabies-HT - human rabies virus immune globulin injection, solution". DailyMed. Retrieved 24 March 2020.
  7. ^ a b "Kedrab- human rabies virus immune globulin injection, solution". DailyMed. Retrieved 24 March 2020.
  8. ^ a b "Hyperrab (rabies immune globulin- human injection, solution". DailyMed. Retrieved 24 March 2020.
  9. ^ "Hyperrab S/D (rabies immune globulin- human injection". DailyMed. Retrieved 10 September 2021.
  10. ^ a b c d e f g h i "Rabies Immune Globulin". The American Society of Health-System Pharmacists. from the original on 18 March 2011. Retrieved 8 January 2017.
  11. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 398. hdl:10665/44053. ISBN 9789241547659.
  12. ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 869. ISBN 9780857111562.
  13. ^ Rupprecht CE, Plotkin SA (2013). "Rabies Vaccines". In Plotkin SA, Orenstein WA, Offit PA (eds.). Vaccines (6th ed.). [Edinburgh]: Elsevier/Saunders. p. 659. ISBN 978-1455700905. from the original on 9 January 2017.
  14. ^ a b Jong EC, Zuckerman JN (2004). Travelers' Vaccines. PMPH-USA. p. 205. ISBN 9781550092257. from the original on 9 January 2017.
  15. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  16. ^ Tintinalli JE (2010). Emergency Medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli)) (7 ed.). New York: McGraw-Hill Companies. p. 1054. ISBN 978-0-07-148480-0.
  17. ^ a b c Research Advances in Rabies. Academic Press. 2011. p. 351. ISBN 9780123870414. from the original on 9 January 2017.
  18. ^ a b "Kedrab". U.S. Food and Drug Administration (FDA). 21 March 2018. Retrieved 7 June 2020.   This article incorporates text from this source, which is in the public domain.
  19. ^ "Summary Basis for Regulatory Action - Kedrab". FDA. 23 August 2017.
  20. ^ "Vaccine and Immune Globulin Availability". Centers for Disease Control and Prevention (CDC). 26 February 2020. Retrieved 24 March 2020.
  21. ^ "WHO Guide for Rabies Pre and Post Exposure Prophylaxis in Humans" (PDF). World Health Organization (WHO). 2014.
  22. ^ "Rabies Biologics | Specific Groups | CDC". www.cdc.gov. 15 January 2021. Retrieved 18 November 2022.

Further reading edit

January 01, 1970
rabies, immunoglobulin, medication, made, antibodies, against, rabies, virus, used, prevent, rabies, following, exposure, given, after, wound, cleaned, with, soap, water, povidone, iodine, followed, course, rabies, vaccine, given, injection, into, site, wound,. Rabies immunoglobulin RIG is a medication made up of antibodies against the rabies virus 10 It is used to prevent rabies following exposure 10 It is given after the wound is cleaned with soap and water or povidone iodine and is followed by a course of rabies vaccine 10 It is given by injection into the site of the wound and into a muscle 10 It is not needed in people who have been previously vaccinated against rabies 11 Rabies immunoglobulinClinical dataTrade namesImogam Rabies HT Kedrab Hyperrab othersAHFS Drugs comMonographPregnancycategoryAU B2 1 Routes ofadministrationIntramuscular injectionATC codeJ06BB05 WHO Legal statusLegal statusAU S4 Prescription only 1 CA only Schedule D 2 3 4 5 US only 6 7 8 9 IdentifiersDrugBankDB11603ChemSpidernoneUNII95F619ATQ2 Common side effects include pain at the site of injection fever and headache 10 Severe allergic reactions such as anaphylaxis may rarely occur 12 Use during pregnancy is not known to harm the baby 10 It works by binding to the rabies virus before it can enter nerve tissue 10 After the virus has entered the central nervous system rabies immunoglobulin is no longer useful 10 The use of rabies immunoglobulin in the form of blood serum dates from 1891 13 Use became common within medicine in the 1950s 14 It is on the World Health Organization s List of Essential Medicines 15 Rabies immunoglobulin is expensive and hard to come by in the developing world 16 In the United States it is estimated to be more than US 1 000 00 per dose 17 It is made from the blood plasma of people or horses who have high levels of the antibody in their blood 10 17 The horse version is less expensive but has a higher rate of side effects 17 14 Contents 1 Medical uses 2 Society and culture 2 1 Names 3 References 4 Further readingMedical uses editRabies immunoglobulin RIG is indicated for the passive transient post exposure prophylaxis of rabies infection when given immediately after contact with a rabid or possibly rabid animal and in combination with a rabies vaccine 18 19 1 Society and culture editNames edit There are three versions of rabies immunoglobulin licensed and available in the US 20 Imogam Rabies HT is produced by Sanofi Pasteur 6 Kedrab is produced by Kedrion Biopharma 18 7 Hyperrab is produced by Grifols 8 Imogam Rabies HT and Kedrab have a nominal potency of 150 IU mL while Hyperrab has a nominal potency of 300 IU mL and requires smaller dosing All three versions are used for post exposure 21 and indicate local infusion at the wound site with additional amount intramuscularly at a site distant from vaccine administration 22 Kamrab is approved for medical use in Australia 1 References edit a b c d Kamrab Therapeutic Goods Administration TGA 23 August 2021 Retrieved 10 September 2021 Kamrab PI Health Canada 25 April 2012 Retrieved 10 September 2021 Imogam PI Health Canada 25 April 2012 Retrieved 10 September 2021 Hyperrab S D PI Health Canada 25 April 2012 Retrieved 10 September 2021 Drug and medical device highlights 2018 Helping you maintain and improve your health Health Canada 14 October 2020 Retrieved 17 April 2024 a b Imogam Rabies HT human rabies virus immune globulin injection solution DailyMed Retrieved 24 March 2020 a b Kedrab human rabies virus immune globulin injection solution DailyMed Retrieved 24 March 2020 a b Hyperrab rabies immune globulin human injection solution DailyMed Retrieved 24 March 2020 Hyperrab S D rabies immune globulin human injection DailyMed Retrieved 10 September 2021 a b c d e f g h i Rabies Immune Globulin The American Society of Health System Pharmacists Archived from the original on 18 March 2011 Retrieved 8 January 2017 World Health Organization 2009 Stuart MC Kouimtzi M Hill SR eds WHO Model Formulary 2008 World Health Organization p 398 hdl 10665 44053 ISBN 9789241547659 British national formulary BNF 69 69 ed British Medical Association 2015 p 869 ISBN 9780857111562 Rupprecht CE Plotkin SA 2013 Rabies Vaccines In Plotkin SA Orenstein WA Offit PA eds Vaccines 6th ed Edinburgh Elsevier Saunders p 659 ISBN 978 1455700905 Archived from the original on 9 January 2017 a b Jong EC Zuckerman JN 2004 Travelers Vaccines PMPH USA p 205 ISBN 9781550092257 Archived from the original on 9 January 2017 World Health Organization 2019 World Health Organization model list of essential medicines 21st list 2019 Geneva World Health Organization hdl 10665 325771 WHO MVP EMP IAU 2019 06 License CC BY NC SA 3 0 IGO Tintinalli JE 2010 Emergency Medicine A Comprehensive Study Guide Emergency Medicine Tintinalli 7 ed New York McGraw Hill Companies p 1054 ISBN 978 0 07 148480 0 a b c Research Advances in Rabies Academic Press 2011 p 351 ISBN 9780123870414 Archived from the original on 9 January 2017 a b Kedrab U S Food and Drug Administration FDA 21 March 2018 Retrieved 7 June 2020 nbsp This article incorporates text from this source which is in the public domain Summary Basis for Regulatory Action Kedrab FDA 23 August 2017 Vaccine and Immune Globulin Availability Centers for Disease Control and Prevention CDC 26 February 2020 Retrieved 24 March 2020 WHO Guide for Rabies Pre and Post Exposure Prophylaxis in Humans PDF World Health Organization WHO 2014 Rabies Biologics Specific Groups CDC www cdc gov 15 January 2021 Retrieved 18 November 2022 Further reading editMeeting of the Antimicrobial Drugs Advisory Committee PDF Briefing Document U S Food and Drug Administration FDA 25 April 2019 Portal nbsp Medicine Retrieved from https en wikipedia org w index php title Rabies immunoglobulin amp oldid 1219466470, wikipedia, wiki, book, books, library,

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