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Albert J. R. Heck

January 19, 2024

Albert J.R. Heck (born 25 November 1964) is a Dutch scientist and professor at Utrecht University, the Netherlands in the field of mass spectrometry and proteomics. He is known for his work on technologies to study proteins in their natural environment, with the aim to understand their biological function. Albert Heck was awarded the Spinoza Prize in 2017, the highest scientific award in the Netherlands.

Albert J.R. Heck
Born (1964-11-25) 25 November 1964 (age 59)
Goes, The Netherlands
NationalityDutch
Alma materUniversity of Amsterdam
Known forProteomics, Native Mass Spectrometry
AwardsDescartes-Huygens Prize (2006)
Spinoza Prize (2017)
Sir Hans Krebs Medal (2018)
Scientific career
FieldsPhysics, Chemistry, Biology
InstitutionsUtrecht University, University of Warwick, Stanford University, University of Amsterdam
Doctoral advisorNico M. M. Nibbering

Biography edit

Albert Heck was born in Goes, Netherlands. He studied chemistry at the VU University in Amsterdam, and received his PhD degree from the University of Amsterdam in 1993. After a postdoctoral period at Stanford University in the lab of Richard Zare and Sandia National Laboratories (Livermore) he became a postdoctoral fellow and later lecturer at University of Warwick.

In 1998 he accepted a chair at Utrecht University as head of the Biomolecular Mass Spectrometry and Proteomics Group.[1] His group is part of the Departments of Chemistry and Pharmaceutical Sciences of the Faculty of Science.[2] From 2006 until 2012 Heck was scientific director of the Bijvoet Centre for Biomolecular Research, and from 2015 to 2018 scientific director of the Utrecht Institute for Pharmaceutical Science at Utrecht University. In 2017 he received a Distinguished Faculty professorship of Utrecht University.[3]

Research edit

The research of Albert Heck is focused on the development and use of mass spectrometry to study all cellular proteins. Within his research group, there are three main lines of research, improvement of instrumentation and analytical methods, proteomics and mass spectrometry based structural biology, including native protein mass spectrometry and cross-linking mass spectrometry.

Albert Heck is regarded as one of the pioneers of native mass spectrometry.[4][5][6] Among the complexes that he studied using native mass spectrometry are intact viruses of up to 18 megadalton,[7][8] ribosomes,[9] antibodies in complex with their antigens[10] or proteins of the complement system.[11][12] He has developed, in collaboration with Alexander Makarov mass spectrometers with extended mass ranges, specifically suited for the analyses of very large protein complexes, which were later commercialized by the company ThermoFisher Scientific as the Orbitrap EMR and UHMR.

In proteomics, Heck is most renowned for his work on quantitative proteomics,[13][14] interactomics,[15] and the analysis of post-translational modification of proteins using mass spectrometry, with a focus on protein phosphorylation[16] and protein glycosylation.[17] This started with the introduction of the material TiO2 as a method for the targeted analysis of phosphopeptides in 2004.[18] The methods developed by Heck have been adopted by many scientists in other fields, to study how protein expression and phosphorylation are regulated in human cells and tissues by different biological processes and disease states.[19][20]

Additionally, he advocated the use of complementary proteases in shot-gun proteomics[21][22] and he introduced and developed novel peptide fragmentation strategies to elucidate site specific post-translational modifications.[23] The latter improves determination of peptide and protein sequence information, which is particular helpful for the analysis of glycopeptides[24] and HLA antigens.[25][26] Heck also contributed to the field of cross-linking mass spectrometry, through proteome wide cross-linking experiments,[27] and the development of novel fragmentation methods and the software suite XlinkX.[28]

Albert Heck is closely involved in coordinating access to proteomics infrastructures in the Netherlands and in Europe. Since 2003 Heck is scientific director of the Netherlands Proteomics Centre.[29] From 2011 to 2015 he was coordinator of PRIME-XS,[30] and since 2019 he coordinates EPIC-XS,[31] both collaborative projects funded by the European Union to enable access to proteomics technology for researchers throughout Europe.

Honours and awards edit

Heck received numerous awards and prizes for his scientific contributions. He received The KNCV golden medal in 2001,[32] the Descartes-Huygens Prize from the Académie de Sciences in 2006,[33] the Life Science Award of the German Mass Spectrometry Society in 2010, the Discovery Award in Proteomic Sciences from the Human Proteome Organization in 2013[34] and the UePA Pioneer Proteomics Award in 2014.

Since 2014 he is a member of the European Molecular Biology Organization.[35][36] In 2014, Heck was elected a member of the Royal Netherlands Academy of Arts and Sciences.[37] The American Chemical Society honoured Albert Heck with the 'Frank H. Field and Joe L. Franklin Award for Outstanding Achievements in Mass Spectrometry' in 2015.[38]

In 2017, he was awarded the Spinoza Prize, the highest scientific distinction in the Netherlands for his "major contribution to the worldwide breakthrough of systematically mapping all proteins in human cells and their biological functions by means of mass spectrometry".[39]

In 2018, he received the Sir Hans Krebs Medal of the Federation of European Biochemical Societies (FEBS) and the Thomson Medal Award of the International Mass Spectrometry Society (IMSC).[40]

References edit

  1. ^ "Catalogus Professorum: Prof.dr. A.J.R. Heck". UU. Retrieved 29 November 2019.
  2. ^ "Hoogleraren" (in Dutch). Volkskrant. 5 September 2012. Retrieved 21 May 2014.
  3. ^ "Albert Heck appointed Distinguished Professor of the Faculty of Science". 1 November 2017. Retrieved 7 January 2020.
  4. ^ "Awards – 2013 Recipients". HUPO. Retrieved 21 May 2014.
  5. ^ Leney, Aneika C.; Heck, Albert J. R. (2017). "Native Mass Spectrometry: What is in the Name?". Journal of the American Society for Mass Spectrometry. 28 (1): 5–13. Bibcode:2017JASMS..28....5L. doi:10.1007/s13361-016-1545-3. PMC 5174146. PMID 27909974.
  6. ^ "Grote complexen intact de MS in" (in Dutch). Chemisch2Weekblad (C2W). 7 June 2013.
  7. ^ Snijder, Joost; Van De Waterbeemd, Michiel; Damoc, Eugen; Denisov, Eduard; Grinfeld, Dmitry; Bennett, Antonette; Agbandje-Mckenna, Mavis; Makarov, Alexander; Heck, Albert J. R. (2014). "Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry". Journal of the American Chemical Society. 136 (20): 7295–7299. doi:10.1021/ja502616y. PMC 4046769. PMID 24787140.
  8. ^ Uetrecht, Charlotte; Heck, Albert J. R. (2011). "Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure, Dynamics, and Assembly". Angewandte Chemie International Edition. 50 (36): 8248–8262. doi:10.1002/anie.201008120. PMC 7159578. PMID 21793131.
  9. ^ Van De Waterbeemd, Michiel; Tamara, Sem; Fort, Kyle L.; Damoc, Eugen; Franc, Vojtech; Bieri, Philipp; Itten, Martin; Makarov, Alexander; Ban, Nenad; Heck, Albert J. R. (2018). "Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods". Nature Communications. 9 (1): 2493. Bibcode:2018NatCo...9.2493V. doi:10.1038/s41467-018-04853-x. PMC 6021402. PMID 29950687.
  10. ^ Rosati, Sara; Rose, Rebecca J.; Thompson, Natalie J.; Van Duijn, Esther; Damoc, Eugen; Denisov, Eduard; Makarov, Alexander; Heck, Albert J. R. (2012). "Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry". Angewandte Chemie International Edition. 51 (52): 12992–12996. doi:10.1002/anie.201206745. PMID 23172610.
  11. ^ Wang, Guanbo; De Jong, Rob N.; Van Den Bremer, Ewald T.J.; Beurskens, Frank J.; Labrijn, Aran F.; Ugurlar, Deniz; Gros, Piet; Schuurman, Janine; Parren, Paul W.H.I.; Heck, Albert J.R. (2016). "Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen". Molecular Cell. 63 (1): 135–145. doi:10.1016/j.molcel.2016.05.016. PMID 27320199.
  12. ^ "Een moleculaire rattenkoning slaat groot immuunalarm" (in Dutch). NRC Handelsblad. 15 March 2014.
  13. ^ Krijgsveld, Jeroen; Ketting, René F.; Mahmoudi, Tokameh; Johansen, Janik; Artal-Sanz, Marta; Verrijzer, C. Peter; Plasterk, Ronald H. A.; Heck, Albert J. R. (2003). "Metabolic labeling of C. Elegans and D. Melanogaster for quantitative proteomics". Nature Biotechnology. 21 (8): 927–931. doi:10.1038/nbt848. PMID 12858183. S2CID 2641430.
  14. ^ Boersema, Paul J.; Raijmakers, Reinout; Lemeer, Simone; Mohammed, Shabaz; Heck, Albert J. R. (2009). "Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics". Nature Protocols. 4 (4): 484–494. doi:10.1038/nprot.2009.21. PMID 19300442. S2CID 5498505.
  15. ^ Liu, Fan; Lössl, Philip; Rabbitts, Beverley M.; Balaban, Robert S.; Heck, Albert J. R. (2018). "The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes". Molecular & Cellular Proteomics. 17 (2): 216–232. doi:10.1074/mcp.RA117.000470. PMC 5795388. PMID 29222160.
  16. ^ "Moeilijk te vangen fosforgroepen" (in Dutch). Chemisch2Weekblad (C2W) Life Sciences. 23 June 2012.
  17. ^ Yang, Yang; Franc, Vojtech; Heck, Albert J.R. (2017). "Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis". Trends in Biotechnology. 35 (7): 598–609. doi:10.1016/j.tibtech.2017.04.010. hdl:1874/351003. PMID 28527536.
  18. ^ Pinkse, Martijn W. H.; Uitto, Pauliina M.; Hilhorst, Martijn J.; Ooms, Bert; Heck, Albert J. R. (2004). "Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns". Analytical Chemistry. 76 (14): 3935–3943. doi:10.1021/ac0498617. PMID 15253627.
  19. ^ Schmidlin, Thierry; Debets, Donna O.; Van Gelder, Charlotte A.G.H.; Stecker, Kelly E.; Rontogianni, Stamatia; Van Den Eshof, Bart L.; Kemper, Kristel; Lips, Esther H.; Van Den Biggelaar, Maartje; Peeper, Daniel S.; Heck, Albert J.R.; Altelaar, Maarten (2019). "High-Throughput Assessment of Kinome-wide Activation States". Cell Systems. 9 (4): 366–374.e5. doi:10.1016/j.cels.2019.08.005. PMC 6838672. PMID 31521607.
  20. ^ Van Hoof, Dennis; Muñoz, Javier; Braam, Stefan R.; Pinkse, Martijn W.H.; Linding, Rune; Heck, Albert J.R.; Mummery, Christine L.; Krijgsveld, Jeroen (2009). "Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells". Cell Stem Cell. 5 (2): 214–226. doi:10.1016/j.stem.2009.05.021. PMID 19664995.
  21. ^ Giansanti, Piero; Tsiatsiani, Liana; Low, Teck Yew; Heck, Albert J. R. (2016). "Six alternative proteases for mass spectrometry–based proteomics beyond trypsin". Nature Protocols. 11 (5): 993–1006. doi:10.1038/nprot.2016.057. hdl:1874/333986. PMID 27123950. S2CID 2597839.
  22. ^ Tsiatsiani, Liana; Heck, Albert J. R. (2015). "Proteomics beyond trypsin". FEBS Journal. 282 (14): 2612–2626. doi:10.1111/febs.13287. PMID 25823410. S2CID 24903856.
  23. ^ Frese, Christian K.; Altelaar, A. F. Maarten; Van Den Toorn, Henk; Nolting, Dirk; Griep-Raming, Jens; Heck, Albert J. R.; Mohammed, Shabaz (2012). "Toward Full Peptide Sequence Coverage by Dual Fragmentation Combining Electron-Transfer and Higher-Energy Collision Dissociation Tandem Mass Spectrometry". Analytical Chemistry. 84 (22): 9668–9673. doi:10.1021/ac3025366. PMID 23106539.
  24. ^ Reiding, Karli R.; Bondt, Albert; Franc, Vojtech; Heck, Albert J.R. (2018). "The benefits of hybrid fragmentation methods for glycoproteomics". Trends in Analytical Chemistry. 108: 260–268. doi:10.1016/j.trac.2018.09.007. hdl:1874/373361. S2CID 105377340.
  25. ^ Mommen, G. P. M.; Frese, C. K.; Meiring, H. D.; Van Gaans-Van Den Brink, J.; De Jong, A. P. J. M.; Van Els, C. A. C. M.; Heck, A. J. R. (2014). "Expanding the detectable HLA peptide repertoire using electron-transfer/Higher-energy collision dissociation (EThcD)". Proceedings of the National Academy of Sciences. 111 (12): 4507–4512. Bibcode:2014PNAS..111.4507M. doi:10.1073/pnas.1321458111. PMC 3970485. PMID 24616531.
  26. ^ Liepe, Juliane; Marino, Fabio; Sidney, John; Jeko, Anita; Bunting, Daniel E.; Sette, Alessandro; Kloetzel, Peter M.; Stumpf, Michael P. H.; Heck, Albert J. R.; Mishto, Michele (2016). "A large fraction of HLA class I ligands are proteasome-generated spliced peptides". Science. 354 (6310): 354–358. Bibcode:2016Sci...354..354L. doi:10.1126/science.aaf4384. hdl:10044/1/42330. PMID 27846572. S2CID 41095551.
  27. ^ Liu, Fan; Rijkers, Dirk T. S.; Post, Harm; Heck, Albert J. R. (2015). "Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry". Nature Methods. 12 (12): 1179–1184. doi:10.1038/nmeth.3603. hdl:1874/329447. PMID 26414014. S2CID 6786537.
  28. ^ Liu, Fan; Lössl, Philip; Scheltema, Richard; Viner, Rosa; Heck, Albert J. R. (2017). "Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification". Nature Communications. 8: 15473. Bibcode:2017NatCo...815473L. doi:10.1038/ncomms15473. PMC 5454533. PMID 28524877.
  29. ^ "Proteins At Work". The Analytical Scientist. 23 February 2014.
  30. ^ Raijmakers, Reinout; Olsen, Jesper V.; Aebersold, Ruedi; Heck, Albert J. R. (2014). "PRIME-XS, a European infrastructure for proteomics". Molecular & Cellular Proteomics. 13 (8): 1901–1904. doi:10.1074/mcp.E114.040162. PMC 4125724. PMID 24958170.
  31. ^ "Proteomics Experts Unite for EPIC-XS". Technology Networks. 22 March 2019. Retrieved 29 November 2019.
  32. ^ "Overzicht KNCV Gouden Medaille Winnaars" (in Dutch). KNCV. Retrieved 29 November 2019.
  33. ^ . KNAW. Archived from the original on 22 March 2019. Retrieved 29 November 2019.
  34. ^ "Most important international proteomics award for Albert Heck". Netherlands Genomics Initiative. 2 October 2013. Retrieved 21 May 2014.
  35. ^ "EMBO announces new members for 2013". EMBO. 21 May 2014. Retrieved 21 May 2014.
  36. ^ "Albert Heck en Ineke Braakman verkozen tot EMBO leden" (in Dutch). Utrecht University. 19 May 2014. Retrieved 21 May 2014.
  37. ^ "KNAW kiest zeventien nieuwe leden" (in Dutch). KNAW. 21 May 2014. Retrieved 21 May 2014.
  38. ^ "Prestigious American Chemical Society awards for Albert Heck and Geert-Jan Boons". UU. 28 August 2015. Retrieved 28 November 2019.
  39. ^ "NWO Spinoza Prizes awarded to Eveline Crone, Albert Heck, Michel Orrit and Alexander van Oudenaarde". NWO. 6 June 2017. Retrieved 28 November 2019.
  40. ^ "Professor Albert Heck is to receive two international distinctions". UU. 3 July 2018. Retrieved 28 November 2019.

External links edit

  • (in English) Website of the EU proteomics infrastructure project EPIC-XS
  • (in English) Website of the Netherlands Proteomics Centre
  • (in English) Website of the Biomolecular Mass Spectrometry and Proteomics Group

January 19, 2024
albert, heck, albert, heck, born, november, 1964, dutch, scientist, professor, utrecht, university, netherlands, field, mass, spectrometry, proteomics, known, work, technologies, study, proteins, their, natural, environment, with, understand, their, biological. Albert J R Heck born 25 November 1964 is a Dutch scientist and professor at Utrecht University the Netherlands in the field of mass spectrometry and proteomics He is known for his work on technologies to study proteins in their natural environment with the aim to understand their biological function Albert Heck was awarded the Spinoza Prize in 2017 the highest scientific award in the Netherlands Albert J R HeckBorn 1964 11 25 25 November 1964 age 59 Goes The NetherlandsNationalityDutchAlma materUniversity of AmsterdamKnown forProteomics Native Mass SpectrometryAwardsDescartes Huygens Prize 2006 Spinoza Prize 2017 Sir Hans Krebs Medal 2018 Scientific careerFieldsPhysics Chemistry BiologyInstitutionsUtrecht University University of Warwick Stanford University University of AmsterdamDoctoral advisorNico M M Nibbering Contents 1 Biography 2 Research 3 Honours and awards 4 References 5 External linksBiography editAlbert Heck was born in Goes Netherlands He studied chemistry at the VU University in Amsterdam and received his PhD degree from the University of Amsterdam in 1993 After a postdoctoral period at Stanford University in the lab of Richard Zare and Sandia National Laboratories Livermore he became a postdoctoral fellow and later lecturer at University of Warwick In 1998 he accepted a chair at Utrecht University as head of the Biomolecular Mass Spectrometry and Proteomics Group 1 His group is part of the Departments of Chemistry and Pharmaceutical Sciences of the Faculty of Science 2 From 2006 until 2012 Heck was scientific director of the Bijvoet Centre for Biomolecular Research and from 2015 to 2018 scientific director of the Utrecht Institute for Pharmaceutical Science at Utrecht University In 2017 he received a Distinguished Faculty professorship of Utrecht University 3 Research editThe research of Albert Heck is focused on the development and use of mass spectrometry to study all cellular proteins Within his research group there are three main lines of research improvement of instrumentation and analytical methods proteomics and mass spectrometry based structural biology including native protein mass spectrometry and cross linking mass spectrometry Albert Heck is regarded as one of the pioneers of native mass spectrometry 4 5 6 Among the complexes that he studied using native mass spectrometry are intact viruses of up to 18 megadalton 7 8 ribosomes 9 antibodies in complex with their antigens 10 or proteins of the complement system 11 12 He has developed in collaboration with Alexander Makarov mass spectrometers with extended mass ranges specifically suited for the analyses of very large protein complexes which were later commercialized by the company ThermoFisher Scientific as the Orbitrap EMR and UHMR In proteomics Heck is most renowned for his work on quantitative proteomics 13 14 interactomics 15 and the analysis of post translational modification of proteins using mass spectrometry with a focus on protein phosphorylation 16 and protein glycosylation 17 This started with the introduction of the material TiO2 as a method for the targeted analysis of phosphopeptides in 2004 18 The methods developed by Heck have been adopted by many scientists in other fields to study how protein expression and phosphorylation are regulated in human cells and tissues by different biological processes and disease states 19 20 Additionally he advocated the use of complementary proteases in shot gun proteomics 21 22 and he introduced and developed novel peptide fragmentation strategies to elucidate site specific post translational modifications 23 The latter improves determination of peptide and protein sequence information which is particular helpful for the analysis of glycopeptides 24 and HLA antigens 25 26 Heck also contributed to the field of cross linking mass spectrometry through proteome wide cross linking experiments 27 and the development of novel fragmentation methods and the software suite XlinkX 28 Albert Heck is closely involved in coordinating access to proteomics infrastructures in the Netherlands and in Europe Since 2003 Heck is scientific director of the Netherlands Proteomics Centre 29 From 2011 to 2015 he was coordinator of PRIME XS 30 and since 2019 he coordinates EPIC XS 31 both collaborative projects funded by the European Union to enable access to proteomics technology for researchers throughout Europe Honours and awards editHeck received numerous awards and prizes for his scientific contributions He received The KNCV golden medal in 2001 32 the Descartes Huygens Prize from the Academie de Sciences in 2006 33 the Life Science Award of the German Mass Spectrometry Society in 2010 the Discovery Award in Proteomic Sciences from the Human Proteome Organization in 2013 34 and the UePA Pioneer Proteomics Award in 2014 Since 2014 he is a member of the European Molecular Biology Organization 35 36 In 2014 Heck was elected a member of the Royal Netherlands Academy of Arts and Sciences 37 The American Chemical Society honoured Albert Heck with the Frank H Field and Joe L Franklin Award for Outstanding Achievements in Mass Spectrometry in 2015 38 In 2017 he was awarded the Spinoza Prize the highest scientific distinction in the Netherlands for his major contribution to the worldwide breakthrough of systematically mapping all proteins in human cells and their biological functions by means of mass spectrometry 39 In 2018 he received the Sir Hans Krebs Medal of the Federation of European Biochemical Societies FEBS and the Thomson Medal Award of the International Mass Spectrometry Society IMSC 40 References edit Catalogus Professorum Prof dr A J R Heck UU Retrieved 29 November 2019 Hoogleraren in Dutch Volkskrant 5 September 2012 Retrieved 21 May 2014 Albert Heck appointed Distinguished Professor of the Faculty of Science 1 November 2017 Retrieved 7 January 2020 Awards 2013 Recipients HUPO Retrieved 21 May 2014 Leney Aneika C Heck Albert J R 2017 Native Mass Spectrometry What is in the Name Journal of the American Society for Mass Spectrometry 28 1 5 13 Bibcode 2017JASMS 28 5L doi 10 1007 s13361 016 1545 3 PMC 5174146 PMID 27909974 Grote complexen intact de MS in in Dutch Chemisch2Weekblad C2W 7 June 2013 Snijder Joost Van De Waterbeemd Michiel Damoc Eugen Denisov Eduard Grinfeld Dmitry Bennett Antonette Agbandje Mckenna Mavis Makarov Alexander Heck Albert J R 2014 Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry Journal of the American Chemical Society 136 20 7295 7299 doi 10 1021 ja502616y PMC 4046769 PMID 24787140 Uetrecht Charlotte Heck Albert J R 2011 Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure Dynamics and Assembly Angewandte Chemie International Edition 50 36 8248 8262 doi 10 1002 anie 201008120 PMC 7159578 PMID 21793131 Van De Waterbeemd Michiel Tamara Sem Fort Kyle L Damoc Eugen Franc Vojtech Bieri Philipp Itten Martin Makarov Alexander Ban Nenad Heck Albert J R 2018 Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods Nature Communications 9 1 2493 Bibcode 2018NatCo 9 2493V doi 10 1038 s41467 018 04853 x PMC 6021402 PMID 29950687 Rosati Sara Rose Rebecca J Thompson Natalie J Van Duijn Esther Damoc Eugen Denisov Eduard Makarov Alexander Heck Albert J R 2012 Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry Angewandte Chemie International Edition 51 52 12992 12996 doi 10 1002 anie 201206745 PMID 23172610 Wang Guanbo De Jong Rob N Van Den Bremer Ewald T J Beurskens Frank J Labrijn Aran F Ugurlar Deniz Gros Piet Schuurman Janine Parren Paul W H I Heck Albert J R 2016 Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen Molecular Cell 63 1 135 145 doi 10 1016 j molcel 2016 05 016 PMID 27320199 Een moleculaire rattenkoning slaat groot immuunalarm in Dutch NRC Handelsblad 15 March 2014 Krijgsveld Jeroen Ketting Rene F Mahmoudi Tokameh Johansen Janik Artal Sanz Marta Verrijzer C Peter Plasterk Ronald H A Heck Albert J R 2003 Metabolic labeling of C Elegans and D Melanogaster for quantitative proteomics Nature Biotechnology 21 8 927 931 doi 10 1038 nbt848 PMID 12858183 S2CID 2641430 Boersema Paul J Raijmakers Reinout Lemeer Simone Mohammed Shabaz Heck Albert J R 2009 Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics Nature Protocols 4 4 484 494 doi 10 1038 nprot 2009 21 PMID 19300442 S2CID 5498505 Liu Fan Lossl Philip Rabbitts Beverley M Balaban Robert S Heck Albert J R 2018 The interactome of intact mitochondria by cross linking mass spectrometry provides evidence for coexisting respiratory supercomplexes Molecular amp Cellular Proteomics 17 2 216 232 doi 10 1074 mcp RA117 000470 PMC 5795388 PMID 29222160 Moeilijk te vangen fosforgroepen in Dutch Chemisch2Weekblad C2W Life Sciences 23 June 2012 Yang Yang Franc Vojtech Heck Albert J R 2017 Glycoproteomics A Balance between High Throughput and In Depth Analysis Trends in Biotechnology 35 7 598 609 doi 10 1016 j tibtech 2017 04 010 hdl 1874 351003 PMID 28527536 Pinkse Martijn W H Uitto Pauliina M Hilhorst Martijn J Ooms Bert Heck Albert J R 2004 Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D NanoLC ESI MS MS and Titanium Oxide Precolumns Analytical Chemistry 76 14 3935 3943 doi 10 1021 ac0498617 PMID 15253627 Schmidlin Thierry Debets Donna O Van Gelder Charlotte A G H Stecker Kelly E Rontogianni Stamatia Van Den Eshof Bart L Kemper Kristel Lips Esther H Van Den Biggelaar Maartje Peeper Daniel S Heck Albert J R Altelaar Maarten 2019 High Throughput Assessment of Kinome wide Activation States Cell Systems 9 4 366 374 e5 doi 10 1016 j cels 2019 08 005 PMC 6838672 PMID 31521607 Van Hoof Dennis Munoz Javier Braam Stefan R Pinkse Martijn W H Linding Rune Heck Albert J R Mummery Christine L Krijgsveld Jeroen 2009 Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells Cell Stem Cell 5 2 214 226 doi 10 1016 j stem 2009 05 021 PMID 19664995 Giansanti Piero Tsiatsiani Liana Low Teck Yew Heck Albert J R 2016 Six alternative proteases for mass spectrometry based proteomics beyond trypsin Nature Protocols 11 5 993 1006 doi 10 1038 nprot 2016 057 hdl 1874 333986 PMID 27123950 S2CID 2597839 Tsiatsiani Liana Heck Albert J R 2015 Proteomics beyond trypsin FEBS Journal 282 14 2612 2626 doi 10 1111 febs 13287 PMID 25823410 S2CID 24903856 Frese Christian K Altelaar A F Maarten Van Den Toorn Henk Nolting Dirk Griep Raming Jens Heck Albert J R Mohammed Shabaz 2012 Toward Full Peptide Sequence Coverage by Dual Fragmentation Combining Electron Transfer and Higher Energy Collision Dissociation Tandem Mass Spectrometry Analytical Chemistry 84 22 9668 9673 doi 10 1021 ac3025366 PMID 23106539 Reiding Karli R Bondt Albert Franc Vojtech Heck Albert J R 2018 The benefits of hybrid fragmentation methods for glycoproteomics Trends in Analytical Chemistry 108 260 268 doi 10 1016 j trac 2018 09 007 hdl 1874 373361 S2CID 105377340 Mommen G P M Frese C K Meiring H D Van Gaans Van Den Brink J De Jong A P J M Van Els C A C M Heck A J R 2014 Expanding the detectable HLA peptide repertoire using electron transfer Higher energy collision dissociation EThcD Proceedings of the National Academy of Sciences 111 12 4507 4512 Bibcode 2014PNAS 111 4507M doi 10 1073 pnas 1321458111 PMC 3970485 PMID 24616531 Liepe Juliane Marino Fabio Sidney John Jeko Anita Bunting Daniel E Sette Alessandro Kloetzel Peter M Stumpf Michael P H Heck Albert J R Mishto Michele 2016 A large fraction of HLA class I ligands are proteasome generated spliced peptides Science 354 6310 354 358 Bibcode 2016Sci 354 354L doi 10 1126 science aaf4384 hdl 10044 1 42330 PMID 27846572 S2CID 41095551 Liu Fan Rijkers Dirk T S Post Harm Heck Albert J R 2015 Proteome wide profiling of protein assemblies by cross linking mass spectrometry Nature Methods 12 12 1179 1184 doi 10 1038 nmeth 3603 hdl 1874 329447 PMID 26414014 S2CID 6786537 Liu Fan Lossl Philip Scheltema Richard Viner Rosa Heck Albert J R 2017 Optimized fragmentation schemes and data analysis strategies for proteome wide cross link identification Nature Communications 8 15473 Bibcode 2017NatCo 815473L doi 10 1038 ncomms15473 PMC 5454533 PMID 28524877 Proteins At Work The Analytical Scientist 23 February 2014 Raijmakers Reinout Olsen Jesper V Aebersold Ruedi Heck Albert J R 2014 PRIME XS a European infrastructure for proteomics Molecular amp Cellular Proteomics 13 8 1901 1904 doi 10 1074 mcp E114 040162 PMC 4125724 PMID 24958170 Proteomics Experts Unite for EPIC XS Technology Networks 22 March 2019 Retrieved 29 November 2019 Overzicht KNCV Gouden Medaille Winnaars in Dutch KNCV Retrieved 29 November 2019 Descartes Huygens Prize KNAW Archived from the original on 22 March 2019 Retrieved 29 November 2019 Most important international proteomics award for Albert Heck Netherlands Genomics Initiative 2 October 2013 Retrieved 21 May 2014 EMBO announces new members for 2013 EMBO 21 May 2014 Retrieved 21 May 2014 Albert Heck en Ineke Braakman verkozen tot EMBO leden in Dutch Utrecht University 19 May 2014 Retrieved 21 May 2014 KNAW kiest zeventien nieuwe leden in Dutch KNAW 21 May 2014 Retrieved 21 May 2014 Prestigious American Chemical Society awards for Albert Heck and Geert Jan Boons UU 28 August 2015 Retrieved 28 November 2019 NWO Spinoza Prizes awarded to Eveline Crone Albert Heck Michel Orrit and Alexander van Oudenaarde NWO 6 June 2017 Retrieved 28 November 2019 Professor Albert Heck is to receive two international distinctions UU 3 July 2018 Retrieved 28 November 2019 External links edit in English Website of the EU proteomics infrastructure project EPIC XS in English Website of the Netherlands Proteomics Centre in English Website of the Biomolecular Mass Spectrometry and Proteomics Group Retrieved from https en wikipedia org w index php title Albert J R Heck amp oldid 1193086760, wikipedia, wiki, book, books, library,

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