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Vasopressin receptor 1B

May 01, 2024

Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene.

AVPR1B
Identifiers
AliasesAVPR1B, AVPR3, arginine vasopressin receptor 1B, V1bR, VPR3
External IDsOMIM: 600264 MGI: 1347010 HomoloGene: 22678 GeneCards: AVPR1B
Orthologs
SpeciesHumanMouse
Entrez

553

26361

Ensembl

ENSG00000198049

ENSMUSG00000026432

UniProt

P47901

Q9WU02

RefSeq (mRNA)

NM_000707

NM_011924

RefSeq (protein)

NP_000698

NP_036054

Location (UCSC)Chr 1: 206.11 – 206.12 MbChr 1: 131.53 – 131.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G protein-coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. It is a major contributor to homeostasis and the control of water, glucose, and salts in the blood. Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. AVPR1b is a G protein-coupled pituitary receptor that has only recently been characterized because of its rarity.[5]

It has been found that the 420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocin receptors.[6] AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin family subfamily.[7]

Tissue distribution edit

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.[8] Subsequent studies have shown that it is also present in the brain and some peripheral tissues.[9][10][11][12]

Clinical significance edit

Behavioral edit

Inactivation of the Avpr1b gene in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.[13] Defensive behaviour and predatory behaviours appear normal in these knockout mice,[14] but there is evidence that social motivation or awareness is reduced.[15] The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters[16] and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.[17] A single nucleotide polymorphism (SNP) has been associated with susceptibility to depression in humans.[6]

Metabolic edit

Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse.[18][19]

Oncology edit

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids[20] responsible for the ectopic ACTH syndrome.[21]

Ligands edit

Nelivaptan (SSR149415)[22] and D-[Leu4-Lys8]-vasopressin[23] are a specific antagonist and agonist for the vasopressin 1b receptor, respectively.

Function edit

AVPR1B is found in different parts of the body and thus has several influences and regulatory actions. Arginine vasopressin influences several symptoms related to affective disorders including significant memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep.[6] Studies have shown that AVPR1B deficiencies produce behavioral changes that can be reversed when the peptide is replaced.[6] These effects are expressed through contact with specific plasma membrane receptors.[6] AVPR1B is responsible for fueling the effects of vasopressin on ACTH release.[7] This interaction takes place as Arginine Vasopressin works with corticotropin releasing hormone to stimulate the pituitary gland to secrete ACTH.[6] AVPR1b is then responsible for mediating the stimulatory effect of vasopressin on ACTH release. Several G proteins are also involved in the signal transduction pathways linked with AVPR1B.[5] These relationships depend on the level of receptor expression and concentration of vasopressin.[5] For example, AVPR1B causes secretion of ACTH from the anterior pituitary cells in a dose-dependent relationship by activating protein kinase C via the Gq/11 protein.[5]

Application edit

There have been several experiments which have studied these interactions further and revealed AVPR1B's role in psychological disorders and regulatory functions. Haplotypes of AVPR1B are associated with increased protective effects to recurrent major depression.[6] AVPR1B has also been associated with higher cortisol responses to psychosocial stress in children with psychiatric disorders compared with carriers of glucocorticoid receptor gene.[24] AVPR1b has also shown involvement in regulation of brain water content and cerebral edema.[25] This was revealed as increased levels of AVPR1B mRNA on the choroid plexus were discovered as a result of increased plasma osmolality.[25] The increase after a reduction of brain water content from salt water loading indicated AVPR1B's role in the neuroendocrine feedback loop in maintaining normal central nervous system fluid balance.[25]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198049 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026432 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the cardiovascular system part 1--receptor physiology". Critical Care. 7 (6): 427–34. doi:10.1186/cc2337. PMC 374366. PMID 14624682.
  6. ^ a b c d e f g van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S (March 2004). "A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Molecular Psychiatry. 9 (3): 287–92. doi:10.1038/sj.mp.4001420. PMID 15094789. S2CID 25408207.
  7. ^ a b "anti-Arginine Vasopressin Receptor 1B (AVPR1B) antibody (ABIN122463)". antibodies-online.
  8. ^ Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA (1984). "Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor". Peptides. 5 (3): 519–22. doi:10.1016/0196-9781(84)90080-9. PMID 6089144. S2CID 3843868.
  9. ^ Hernando F, Schoots O, Lolait SJ, Burbach JP (2001). "Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin". Endocrinology. 142 (4): 1659–68. doi:10.1210/endo.142.4.8067. PMID 11250948.
  10. ^ Young WS, Li J, Wersinger SR, Palkovits M (2006). "The Vasopressin 1b Receptor is Prominent in the Hippocampal Area CA2 Where It Is Unaffected by Restraint Stress or Adrenalectomy". Neuroscience. 143 (4): 1031–9. doi:10.1016/j.neuroscience.2006.08.040. PMC 1748954. PMID 17027167.
  11. ^ Lolait SJ, O'Carroll AM, Mahan LC, Felder CC, Button DC, Young WS, Mezey E, Brownstein MJ (July 1995). "Extrapituitary expression of the rat V1b vasopressin receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 6783–7. Bibcode:1995PNAS...92.6783L. doi:10.1073/pnas.92.15.6783. PMC 41413. PMID 7624319.
  12. ^ Lolait SJ, Roper JA, Hazell GG, Li Y, Thomson FJ, O'Carroll AM (2016). "10: Neuropeptide receptors". In Murphy E, Gainer H (eds.). Molecular Neuroendocrinology: From Genome to Physiology. Wiley-Blackwell. pp. 195–218. doi:10.1002/9781118760369.ch10. ISBN 9781118760369.
  13. ^ Wersinger SR, Ginns EI, O'Carroll AM, Lolait SJ, Young WS (2002). "AVPR1B knockout reduces aggressive behavior in male mice". Mol. Psychiatry. 7 (9): 975–84. doi:10.1038/sj.mp.4001195. PMID 12399951. S2CID 12267433.
  14. ^ Wersinger SR, Caldwell HK, Christiansen M, Young WS (2007). "Disruption of the Vasopressin 1b Receptor Gene Impairs the Attack Component of Aggressive Behavior in Mice". Genes, Brain and Behavior. 6 (7): 653–60. doi:10.1111/j.1601-183X.2006.00294.x. PMC 2486432. PMID 17284170.
  15. ^ Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS (2004). "Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task". Hormones and Behavior. 46 (5): 638–45. doi:10.1016/j.yhbeh.2004.07.004. PMID 15555506. S2CID 38444963.
  16. ^ Blanchard RJ, Griebel G, Farrokhi C, Markham C, Yang M, Blanchard DC (2005). "AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters". Pharmacology Biochemistry and Behavior. 80 (1): 189–94. doi:10.1016/j.pbb.2004.10.024. PMID 15652395. S2CID 236345.
  17. ^ Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A (2005). "An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders". CNS Drug Reviews. 11 (1): 53–68. doi:10.1111/j.1527-3458.2005.tb00035.x. PMC 6741711. PMID 15867952.
  18. ^ Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM (2007). "The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors". Endocrinology. 148 (2): 849–56. doi:10.1210/en.2006-1309. PMC 2040022. PMID 17122081.
  19. ^ Roper J, O'Carroll AM, Young W, Lolait S (January 2011). "The vasopressin Avpr1b receptor: molecular and pharmacological studies". Stress. 14 (1): 98–115. doi:10.3109/10253890.2010.512376. PMC 3016603. PMID 20828336.
  20. ^ Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). "Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro". Clinical Endocrinology. 47 (5): 623–7. doi:10.1046/j.1365-2265.1997.3091129.x. PMID 9425403. S2CID 7833666.
  21. ^ de Keyzer Y, Lenne F, Auzan C, Jégou S, René P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X (1996). "The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". Journal of Clinical Investigation. 97 (5): 1311–8. doi:10.1172/JCI118547. PMC 507185. PMID 8636444.
  22. ^ Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G (2002). "Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist". Journal of Pharmacology and Experimental Therapeutics. 300 (3): 1122–30. doi:10.1124/jpet.300.3.1122. PMID 11861823. S2CID 15987154.
  23. ^ Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G, Serradeil-Le Gal C, Manning M, Guillon G (2007). "Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology. 148 (9): 4136–46. doi:10.1210/en.2006-1633. PMID 17495006.
  24. ^ van West D, Del-Favero J, Deboutte D, Van Broeckhoven C, Claes S (August 2010). "Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population". Psychiatry Research. 179 (1): 64–8. doi:10.1016/j.psychres.2009.04.002. PMID 20472303. S2CID 25578813.
  25. ^ a b c Zemo DA, McCabe JT (2001). "Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus". Neuropeptides. 35 (3–4): 181–8. doi:10.1054/npep.2001.0864. PMID 11884209. S2CID 9507417.

External links edit

  • Receptors,+Vasopressin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • "Symbol Report: AVPR1B". HUGO Gene Nomenclature Committee (HGNC).
  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-07-23.
  • Human AVPR1B genome location and AVPR1B gene details page in the UCSC Genome Browser.
  • "Receptor 1B (AVPR1B)". the product can be provided by the Abbexa Ltd.

May 01, 2024
vasopressin, receptor, vasopressin, receptor, v1br, also, known, vasopressin, receptor, vpr3, antidiuretic, hormone, receptor, protein, that, humans, encoded, avpr1b, arginine, vasopressin, receptor, gene, avpr1bidentifiersaliasesavpr1b, avpr3, arginine, vasop. Vasopressin V1b receptor V1BR also known as vasopressin 3 receptor VPR3 or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B arginine vasopressin receptor 1B gene AVPR1BIdentifiersAliasesAVPR1B AVPR3 arginine vasopressin receptor 1B V1bR VPR3External IDsOMIM 600264 MGI 1347010 HomoloGene 22678 GeneCards AVPR1BGene location Human Chr Chromosome 1 human 1 Band1q32 1Start206 106 936 bp 1 End206 117 699 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 E4Start131 526 977 bp 2 End131 539 738 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inanterior pituitaryendothelial cellsecondary oocyteislet of Langerhansvisceral pleuraduodenummetanephrosembryoganglionic eminencerenal cortexTop expressed inmeningesblastocystspinal cordhippocampus propervasculatureislet of Langerhanshypothalamusamygdalaventricular systemchoroid plexusMore reference expression dataBioGPSn aGene ontologyMolecular functionpeptide binding G protein coupled receptor activity signal transducer activity protein kinase C binding vasopressin receptor activityCellular componentintegral component of membrane endosome plasma membrane integral component of plasma membrane membraneBiological processpositive regulation of cytosolic calcium ion concentration G protein coupled receptor signaling pathway regulation of systemic arterial blood pressure by vasopressin cellular response to hormone stimulus activation of phospholipase C activity positive regulation of vasoconstriction signal transduction response to peptideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez55326361EnsemblENSG00000198049ENSMUSG00000026432UniProtP47901Q9WU02RefSeq mRNA NM 000707NM 011924RefSeq protein NP 000698NP 036054Location UCSC Chr 1 206 11 206 12 MbChr 1 131 53 131 54 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse V1BR acts as a receptor for vasopressin AVPR1B belongs to the subfamily of G protein coupled receptors Its activity is mediated by G proteins which stimulate a phosphatidylinositol calcium second messenger system It is a major contributor to homeostasis and the control of water glucose and salts in the blood Arginine vasopressin has four receptors each of which are located in different tissues and have specific functions AVPR1b is a G protein coupled pituitary receptor that has only recently been characterized because of its rarity 5 It has been found that the 420 amino acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A AVP2 and oxytocin receptors 6 AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin oxytocin family subfamily 7 Contents 1 Tissue distribution 2 Clinical significance 2 1 Behavioral 2 2 Metabolic 2 3 Oncology 3 Ligands 4 Function 5 Application 6 References 7 External linksTissue distribution editAVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary where it stimulates ACTH release 8 Subsequent studies have shown that it is also present in the brain and some peripheral tissues 9 10 11 12 Clinical significance editBehavioral edit Inactivation of the Avpr1b gene in mice knockout produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice 13 Defensive behaviour and predatory behaviours appear normal in these knockout mice 14 but there is evidence that social motivation or awareness is reduced 15 The AVPR1B antagonist SSR149415 has been shown to have anti aggressive actions in hamsters 16 and anti depressant and anxiety anxiolytic like behaviors in rats 17 A single nucleotide polymorphism SNP has been associated with susceptibility to depression in humans 6 Metabolic edit Various stress induced elevations of ACTH are blunted in the Avpr1b knockout mouse 18 19 Oncology edit AVPR1B is expressed at high levels in ACTH secreting pituitary adenomas as well as in bronchial carcinoids 20 responsible for the ectopic ACTH syndrome 21 Ligands editNelivaptan SSR149415 22 and D Leu4 Lys8 vasopressin 23 are a specific antagonist and agonist for the vasopressin 1b receptor respectively Function editAVPR1B is found in different parts of the body and thus has several influences and regulatory actions Arginine vasopressin influences several symptoms related to affective disorders including significant memory processes pain sensitivity synchronization of biological rhythms and the timing and quality of REM sleep 6 Studies have shown that AVPR1B deficiencies produce behavioral changes that can be reversed when the peptide is replaced 6 These effects are expressed through contact with specific plasma membrane receptors 6 AVPR1B is responsible for fueling the effects of vasopressin on ACTH release 7 This interaction takes place as Arginine Vasopressin works with corticotropin releasing hormone to stimulate the pituitary gland to secrete ACTH 6 AVPR1b is then responsible for mediating the stimulatory effect of vasopressin on ACTH release Several G proteins are also involved in the signal transduction pathways linked with AVPR1B 5 These relationships depend on the level of receptor expression and concentration of vasopressin 5 For example AVPR1B causes secretion of ACTH from the anterior pituitary cells in a dose dependent relationship by activating protein kinase C via the Gq 11 protein 5 Application editThere have been several experiments which have studied these interactions further and revealed AVPR1B s role in psychological disorders and regulatory functions Haplotypes of AVPR1B are associated with increased protective effects to recurrent major depression 6 AVPR1B has also been associated with higher cortisol responses to psychosocial stress in children with psychiatric disorders compared with carriers of glucocorticoid receptor gene 24 AVPR1b has also shown involvement in regulation of brain water content and cerebral edema 25 This was revealed as increased levels of AVPR1B mRNA on the choroid plexus were discovered as a result of increased plasma osmolality 25 The increase after a reduction of brain water content from salt water loading indicated AVPR1B s role in the neuroendocrine feedback loop in maintaining normal central nervous system fluid balance 25 References edit a b c GRCh38 Ensembl release 89 ENSG00000198049 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026432 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c d Holmes CL Landry DW Granton JT December 2003 Science review Vasopressin and the cardiovascular system part 1 receptor physiology Critical Care 7 6 427 34 doi 10 1186 cc2337 PMC 374366 PMID 14624682 a b c d e f g van West D Del Favero J Aulchenko Y Oswald P Souery D Forsgren T Sluijs S Bel Kacem S Adolfsson R Mendlewicz J Van Duijn C Deboutte D Van Broeckhoven C Claes S March 2004 A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression Molecular Psychiatry 9 3 287 92 doi 10 1038 sj mp 4001420 PMID 15094789 S2CID 25408207 a b anti Arginine Vasopressin Receptor 1B AVPR1B antibody ABIN122463 antibodies online Antoni FA Holmes MC Makara GB Karteszi M Laszlo FA 1984 Evidence that the effects of arginine 8 vasopressin AVP on pituitary corticotropin ACTH release are mediated by a novel type of receptor Peptides 5 3 519 22 doi 10 1016 0196 9781 84 90080 9 PMID 6089144 S2CID 3843868 Hernando F Schoots O Lolait SJ Burbach JP 2001 Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland anatomical support for its involvement in the central effects of vasopressin Endocrinology 142 4 1659 68 doi 10 1210 endo 142 4 8067 PMID 11250948 Young WS Li J Wersinger SR Palkovits M 2006 The Vasopressin 1b Receptor is Prominent in the Hippocampal Area CA2 Where It Is Unaffected by Restraint Stress or Adrenalectomy Neuroscience 143 4 1031 9 doi 10 1016 j neuroscience 2006 08 040 PMC 1748954 PMID 17027167 Lolait SJ O Carroll AM Mahan LC Felder CC Button DC Young WS Mezey E Brownstein MJ July 1995 Extrapituitary expression of the rat V1b vasopressin receptor gene Proceedings of the National Academy of Sciences of the United States of America 92 15 6783 7 Bibcode 1995PNAS 92 6783L doi 10 1073 pnas 92 15 6783 PMC 41413 PMID 7624319 Lolait SJ Roper JA Hazell GG Li Y Thomson FJ O Carroll AM 2016 10 Neuropeptide receptors In Murphy E Gainer H eds Molecular Neuroendocrinology From Genome to Physiology Wiley Blackwell pp 195 218 doi 10 1002 9781118760369 ch10 ISBN 9781118760369 Wersinger SR Ginns EI O Carroll AM Lolait SJ Young WS 2002 AVPR1B knockout reduces aggressive behavior in male mice Mol Psychiatry 7 9 975 84 doi 10 1038 sj mp 4001195 PMID 12399951 S2CID 12267433 Wersinger SR Caldwell HK Christiansen M Young WS 2007 Disruption of the Vasopressin 1b Receptor Gene Impairs the Attack Component of Aggressive Behavior in Mice Genes Brain and Behavior 6 7 653 60 doi 10 1111 j 1601 183X 2006 00294 x PMC 2486432 PMID 17284170 Wersinger SR Kelliher KR Zufall F Lolait SJ O Carroll AM Young WS 2004 Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task Hormones and Behavior 46 5 638 45 doi 10 1016 j yhbeh 2004 07 004 PMID 15555506 S2CID 38444963 Blanchard RJ Griebel G Farrokhi C Markham C Yang M Blanchard DC 2005 AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters Pharmacology Biochemistry and Behavior 80 1 189 94 doi 10 1016 j pbb 2004 10 024 PMID 15652395 S2CID 236345 Serradeil Le Gal C Wagnon J Tonnerre B Roux R Garcia G Griebel G Aulombard A 2005 An overview of SSR149415 a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress related disorders CNS Drug Reviews 11 1 53 68 doi 10 1111 j 1527 3458 2005 tb00035 x PMC 6741711 PMID 15867952 Lolait SJ Stewart LQ Jessop DS Young WS O Carroll AM 2007 The Hypothalamic Pituitary Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors Endocrinology 148 2 849 56 doi 10 1210 en 2006 1309 PMC 2040022 PMID 17122081 Roper J O Carroll AM Young W Lolait S January 2011 The vasopressin Avpr1b receptor molecular and pharmacological studies Stress 14 1 98 115 doi 10 3109 10253890 2010 512376 PMC 3016603 PMID 20828336 Arlt W Dahia PL Callies F Nordmeyer JP Allolio B Grossman AB Reincke M 1997 Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro Clinical Endocrinology 47 5 623 7 doi 10 1046 j 1365 2265 1997 3091129 x PMID 9425403 S2CID 7833666 de Keyzer Y Lenne F Auzan C Jegou S Rene P Vaudry H Kuhn JM Luton JP Clauser E Bertagna X 1996 The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome Journal of Clinical Investigation 97 5 1311 8 doi 10 1172 JCI118547 PMC 507185 PMID 8636444 Serradeil Le Gal C Wagnon J Simiand J Griebel G Lacour C Guillon G Barberis C Brossard G Soubrie P Nisato D Pascal M Pruss R Scatton B Maffrand JP Le Fur G 2002 Characterization of 2S 4R 1 5 chloro 1 2 4 dimethoxyphenyl sulfonyl 3 2 methoxy phenyl 2 oxo 2 3 dihydro 1H indol 3 yl 4 hydroxy N N dimethyl 2 pyrrolidine carboxamide SSR149415 a selective and orally active vasopressin V1b receptor antagonist Journal of Pharmacology and Experimental Therapeutics 300 3 1122 30 doi 10 1124 jpet 300 3 1122 PMID 11861823 S2CID 15987154 Pena A Murat B Trueba M Ventura MA Bertrand G Cheng LL Stoev S Szeto HH Wo N Brossard G Serradeil Le Gal C Manning M Guillon G 2007 Pharmacological and physiological characterization of d Leu4 Lys8 vasopressin the first V1b selective agonist for rat vasopressin oxytocin receptors Endocrinology 148 9 4136 46 doi 10 1210 en 2006 1633 PMID 17495006 van West D Del Favero J Deboutte D Van Broeckhoven C Claes S August 2010 Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population Psychiatry Research 179 1 64 8 doi 10 1016 j psychres 2009 04 002 PMID 20472303 S2CID 25578813 a b c Zemo DA McCabe JT 2001 Salt loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus Neuropeptides 35 3 4 181 8 doi 10 1054 npep 2001 0864 PMID 11884209 S2CID 9507417 External links editReceptors Vasopressin at the U S National Library of Medicine Medical Subject Headings MeSH Symbol Report AVPR1B HUGO Gene Nomenclature Committee HGNC Vasopressin and Oxytocin Receptors V1B IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2007 07 23 Human AVPR1B genome location and AVPR1B gene details page in the UCSC Genome Browser Receptor 1B AVPR1B the product can be provided by the Abbexa Ltd Retrieved from https en wikipedia org w index php title Vasopressin receptor 1B amp oldid 1212901830, wikipedia, wiki, book, books, library,

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