This gene encodes a component of vacuolarATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026394 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
Finbow ME, Harrison MA (Jun 1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". The Biochemical Journal. 324 (Pt 3): 697–712. doi:10.1042/bj3240697. PMC1218484. PMID 9210392.
Nelson N, Harvey WR (Apr 1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiological Reviews. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
Forgac M (May 1999). "Structure and properties of the vacuolar (H+)-ATPases". The Journal of Biological Chemistry. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
Kane PM (Feb 1999). "Introduction: V-ATPases 1992-1998". Journal of Bioenergetics and Biomembranes. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
Nishi T, Forgac M (Feb 2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nature Reviews Molecular Cell Biology. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
Kawasaki-Nishi S, Nishi T, Forgac M (Jun 2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Letters. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
Morel N (Oct 2003). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biology of the Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
Brown D, Lui B, Gluck S, Sabolić I (Oct 1992). "A plasma membrane proton ATPase in specialized cells of rat epididymis". The American Journal of Physiology. 263 (4 Pt 1): C913–6. doi:10.1152/ajpcell.1992.263.4.C913. PMID 1415677.
Smith AN, Borthwick KJ, Karet FE (Sep 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.
External linksedit
Human ATP6V1G3 genome location and ATP6V1G3 gene details page in the UCSC Genome Browser.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
atp6v1g3, type, proton, atpase, subunit, enzyme, that, humans, encoded, gene, identifiersaliases, atp6g3, vma10, atpase, transporting, subunit, g3external, idsomim, 618071, 2450548, homologene, 13630, genecards, gene, location, human, chromosome, human, band1q. V type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene 5 6 ATP6V1G3IdentifiersAliasesATP6V1G3 ATP6G3 Vma10 ATPase H transporting V1 subunit G3External IDsOMIM 618071 MGI 2450548 HomoloGene 13630 GeneCards ATP6V1G3Gene location Human Chr Chromosome 1 human 1 Band1q31 3Start198 523 222 bp 1 End198 540 945 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 E4Start138 201 476 bp 2 End138 217 200 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inkidneyminor salivary glandslymph nodeganglionic eminencethymusbone marrowprostateplacentaspleenliverTop expressed inkidneyrenal cortexskinzone of skinlimbMore reference expression dataBioGPSn aGene ontologyMolecular functionATPase binding P type proton exporting transporter activity ATPase coupled transmembrane transporter activityCellular componentcytosol plasma membrane vacuolar proton transporting V type ATPase complexBiological processproton transmembrane transport insulin receptor signaling pathway ion transmembrane transport ion transport transferrin transport phagosome acidificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez127124338375EnsemblENSG00000151418ENSG00000263014ENSMUSG00000026394UniProtQ96LB4Q8BMC1RefSeq mRNA NM 133262NM 133326NM 001320218NM 001376861NM 001376862NM 001376863NM 177397RefSeq protein NP 001307147NP 573569NP 579872NP 001363790NP 001363791NP 001363792NP 796371Location UCSC Chr 1 198 52 198 54 MbChr 1 138 2 138 22 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene encodes a component of vacuolar ATPase V ATPase a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles V ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting zymogen activation receptor mediated endocytosis and synaptic vesicle proton gradient generation V ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain The V1 domain consists of three A and three B subunits two G subunits plus the C D E F and H subunits The V1 domain contains the ATP catalytic site The V0 domain consists of five different subunits a c c c and d Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants This gene encodes one of three G subunit proteins Transcript variants encoding different isoforms have been found for this gene 6 References edit a b c ENSG00000263014 GRCh38 Ensembl release 89 ENSG00000151418 ENSG00000263014 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026394 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Stevens TH Forgac M Feb 1998 Structure function and regulation of the vacuolar H ATPase Annual Review of Cell and Developmental Biology 13 779 808 doi 10 1146 annurev cellbio 13 1 779 PMID 9442887 a b Entrez Gene ATP6V1G3 ATPase H transporting lysosomal 13kDa V1 subunit G3 Further reading editFinbow ME Harrison MA Jun 1997 The vacuolar H ATPase a universal proton pump of eukaryotes The Biochemical Journal 324 Pt 3 697 712 doi 10 1042 bj3240697 PMC 1218484 PMID 9210392 Nelson N Harvey WR Apr 1999 Vacuolar and plasma membrane proton adenosinetriphosphatases Physiological Reviews 79 2 361 85 doi 10 1152 physrev 1999 79 2 361 PMID 10221984 S2CID 1477911 Forgac M May 1999 Structure and properties of the vacuolar H ATPases The Journal of Biological Chemistry 274 19 12951 4 doi 10 1074 jbc 274 19 12951 PMID 10224039 Kane PM Feb 1999 Introduction V ATPases 1992 1998 Journal of Bioenergetics and Biomembranes 31 1 3 5 doi 10 1023 A 1001884227654 PMID 10340843 Wieczorek H Brown D Grinstein S Ehrenfeld J Harvey WR Aug 1999 Animal plasma membrane energization by proton motive V ATPases BioEssays 21 8 637 48 doi 10 1002 SICI 1521 1878 199908 21 8 lt 637 AID BIES3 gt 3 0 CO 2 W PMID 10440860 S2CID 23505139 Nishi T Forgac M Feb 2002 The vacuolar H ATPases nature s most versatile proton pumps Nature Reviews Molecular Cell Biology 3 2 94 103 doi 10 1038 nrm729 PMID 11836511 S2CID 21122465 Kawasaki Nishi S Nishi T Forgac M Jun 2003 Proton translocation driven by ATP hydrolysis in V ATPases FEBS Letters 545 1 76 85 doi 10 1016 S0014 5793 03 00396 X PMID 12788495 S2CID 10507213 Morel N Oct 2003 Neurotransmitter release the dark side of the vacuolar H ATPase Biology of the Cell 95 7 453 7 doi 10 1016 S0248 4900 03 00075 3 PMID 14597263 Brown D Lui B Gluck S Sabolic I Oct 1992 A plasma membrane proton ATPase in specialized cells of rat epididymis The American Journal of Physiology 263 4 Pt 1 C913 6 doi 10 1152 ajpcell 1992 263 4 C913 PMID 1415677 Smith AN Borthwick KJ Karet FE Sep 2002 Molecular cloning and characterization of novel tissue specific isoforms of the human vacuolar H ATPase C G and d subunits and their evaluation in autosomal recessive distal renal tubular acidosis Gene 297 1 2 169 77 doi 10 1016 S0378 1119 02 00884 3 PMID 12384298 External links editHuman ATP6V1G3 genome location and ATP6V1G3 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ATP6V1G3 amp oldid 1115438844, wikipedia, wiki, book, books, library,
