A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269.[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.[2][3] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.[4]
^Moreland RB, Patel M, Hsieh GC, Wetter JM, Marsh K, Brioni JD (September 2005). "A-412997 is a selective dopamine D4 receptor agonist in rats". Pharmacology Biochemistry and Behavior. 82 (1): 140–7. doi:10.1016/j.pbb.2005.08.001. PMID 16153699. S2CID 10270715.
^Browman KE, Curzon P, Pan JB, Molesky AL, Komater VA, Decker MW, et al. (September 2005). "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats". Pharmacology Biochemistry and Behavior. 82 (1): 148–55. doi:10.1016/j.pbb.2005.08.002. PMID 16154186. S2CID 31796938.
^Woolley ML, Waters KA, Reavill C, Bull S, Lacroix LP, Martyn AJ, et al. (December 2008). "Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat". Behavioural Pharmacology. 19 (8): 765–76. doi:10.1097/FBP.0b013e32831c3b06. PMID 19020411. S2CID 36272297.
^Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, et al. (May 2005). "Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets". Pharmacology Biochemistry and Behavior. 81 (1): 211–9. doi:10.1016/j.pbb.2005.03.012. PMID 15894081. S2CID 46690866.
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412997, drug, which, acts, dopamine, agonist, that, used, scientific, research, first, drug, developed, that, highly, selective, agonist, subtype, with, significantly, improved, selectivity, over, older, preferring, compounds, such, animal, tests, improved, co. A 412 997 is a drug which acts as a dopamine agonist that is used in scientific research It is the first drug developed that is a highly selective agonist for the D4 subtype with significantly improved selectivity over older D4 preferring compounds such as PD 168 077 and CP 226 269 1 In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate but without producing place preference or other signs of abuse liability 2 3 Also unlike other dopamine agonists selective D4 agonists do not cause side effects such as sedation and nausea and so might have advantages over older dopamine agonist drugs 4 A 412997IdentifiersIUPAC name N 3 methylphenyl 2 4 pyridin 2 ylpiperidin 1 yl acetamideCAS Number630116 49 3 1347744 96 0 di hydrochloride PubChem CID10425450IUPHAR BPS3301ChemSpider8600878 YUNIIRWL9H93ARBChEMBLChEMBL375596 YCompTox Dashboard EPA DTXSID70212234Chemical and physical dataFormulaC 19H 23N 3OMolar mass309 413 g mol 13D model JSmol Interactive imageSMILES CC1 CC NC CN2CCC C3 CC CC N3 CC2 O CC C1InChI InChI 1S C19H23N3O c1 15 5 4 6 17 13 15 21 19 23 14 22 11 8 16 9 12 22 18 7 2 3 10 20 18 h2 7 10 13 16H 8 9 11 12 14H2 1H3 H 21 23 YKey JFCDMGGMCUKHST UHFFFAOYSA N Y verify References edit Moreland RB Patel M Hsieh GC Wetter JM Marsh K Brioni JD September 2005 A 412997 is a selective dopamine D4 receptor agonist in rats Pharmacology Biochemistry and Behavior 82 1 140 7 doi 10 1016 j pbb 2005 08 001 PMID 16153699 S2CID 10270715 Browman KE Curzon P Pan JB Molesky AL Komater VA Decker MW et al September 2005 A 412997 a selective dopamine D4 agonist improves cognitive performance in rats Pharmacology Biochemistry and Behavior 82 1 148 55 doi 10 1016 j pbb 2005 08 002 PMID 16154186 S2CID 31796938 Woolley ML Waters KA Reavill C Bull S Lacroix LP Martyn AJ et al December 2008 Selective dopamine D4 receptor agonist A 412997 improves cognitive performance and stimulates motor activity without influencing reward related behaviour in rat Behavioural Pharmacology 19 8 765 76 doi 10 1097 FBP 0b013e32831c3b06 PMID 19020411 S2CID 36272297 Osinski MA Uchic ME Seifert T Shaughnessy TK Miller LN Nakane M et al May 2005 Dopamine D2 but not D4 receptor agonists are emetogenic in ferrets Pharmacology Biochemistry and Behavior 81 1 211 9 doi 10 1016 j pbb 2005 03 012 PMID 15894081 S2CID 46690866 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title A 412997 amp oldid 1122683875, wikipedia, wiki, book, books, library,
