5-Hydroxyuracil is an oxidized form of cytosine that is produced by the oxidative deamination of cytosines by reactive oxygen species.[1] It does not distort the DNA molecule and is bypassed by replicative DNA polymerases. It can miscode for adenine and is potentially mutagenic.[2]
^Varatharasa Thiviyanathan; Anoma Somasunderam; David E. Volka & David G. Gorenstein (2005). "5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex". Chem. Commun. (3): 400–402. doi:10.1039/B414474K. PMID 15645051.
^Helmut Greim; Richard J. Albertini (2012). The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens. Royal Society of Chemistry. ISBN9781849731775. Retrieved July 20, 2015.
February 07, 2023
hydroxyuracil, oxidized, form, cytosine, that, produced, oxidative, deamination, cytosines, reactive, oxygen, species, does, distort, molecule, bypassed, replicative, polymerases, miscode, adenine, potentially, mutagenic, namesiupac, name, pyrimidinetriolother. 5 Hydroxyuracil is an oxidized form of cytosine that is produced by the oxidative deamination of cytosines by reactive oxygen species 1 It does not distort the DNA molecule and is bypassed by replicative DNA polymerases It can miscode for adenine and is potentially mutagenic 2 5 Hydroxyuracil NamesIUPAC name 2 4 5 PyrimidinetriolOther names 5 Hydroxy 2 4 1H 3H pyrimidinedioneIdentifiersCAS Number 496 76 4 Y3D model JSmol Interactive imageChEBI CHEBI 29115ChEMBL ChEMBL1561505ChemSpider 66014ECHA InfoCard 100 007 119EC Number 207 829 9PubChem CID 73268UNII 438WJI1S49 YCompTox Dashboard EPA DTXSID30174667InChI InChI 1S C4H4N2O3 c7 2 1 5 4 9 6 3 2 8 h1 7H H2 5 6 8 9 Key OFJNVANOCZHTMW UHFFFAOYSA NSMILES c1c c nc n1 O O OPropertiesChemical formula C 4H 4N 2O 3Molar mass 128 087 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox referencesReferences Edit Varatharasa Thiviyanathan Anoma Somasunderam David E Volka amp David G Gorenstein 2005 5 Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex Chem Commun 3 400 402 doi 10 1039 B414474K PMID 15645051 Helmut Greim Richard J Albertini 2012 The Cellular Response to the Genotoxic Insult The Question of Threshold for Genotoxic Carcinogens Royal Society of Chemistry ISBN 9781849731775 Retrieved July 20 2015 Retrieved from https en wikipedia org w index php title 5 Hydroxyuracil amp oldid 1094132520, wikipedia, wiki, book, books, library,
