It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]
^Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.
January 01, 1970
methyl, gaba, also, known, hms3266k11, anticonvulsant, alkaloid, names, iupac, name, amino, methylbutanoic, acid, other, names, hms3266k11hms3411g19, identifiers, number, 71135, model, jsmol, interactive, image, chebi, chebi, 93881, chembl, chembl275655, chems. 3 Methyl GABA also known as HMS3266K11 is an anticonvulsant alkaloid 3 Methyl GABA Names IUPAC name 4 Amino 3 methylbutanoic acid Other names HMS3266K11HMS3411G19 Identifiers CAS Number 71135 23 4 3D model JSmol Interactive image ChEBI CHEBI 93881 ChEMBL ChEMBL275655 ChemSpider 2778160 PubChem CID 3539719 InChI InChI 1S C5H11NO2 c1 4 3 6 2 5 7 8 h4H 2 3 6H2 1H3 H 7 8 Key CZGLBWZXGIAIBU UHFFFAOYSA N SMILES CC CC O O CN Properties Chemical formula C 5H 11N O 2 Molar mass 117 148 g mol 1 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox referencesPharmacology edit3 Methyl GABA is an activator of GABA T an enzyme that transforms GABA to succinate semialdehyde and glutamate 1 It also activates glutamate decarboxylase an enzyme that is needed in GABA synthesis This is thought to be the primary mechanism of action behind its anticonvulsant action 2 3 References edit https www tocris com products 3 methyl gaba 0386 https www medchemexpress com 3 methyl gaba html Silverman Richard B Andruszkiewicz Ryszard Nanavati Shrenik M Taylor Charles P Vartanian Mark G 1991 3 Alkyl 4 aminobutyric acids The first class of anticonvulsant agents that activates L glutamic acid decarboxylase Journal of Medicinal Chemistry 34 7 2295 2298 doi 10 1021 jm00111a053 PMID 2067001 Retrieved from https en wikipedia org w index php title 3 Methyl GABA amp oldid 1203899205, wikipedia, wiki, book, books, library,
