fbpx
Wikipedia

3-Methoxy-4-hydroxyphenylglycol

3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation. In the brain, it is the principal norepinephrine metabolite. It is released into the blood and cerebrospinal fluid,[1] and a blood sample of it may therefore be an indication of recent sympathetic nervous system activity.

3-Methoxy-4-hydroxyphenylglycol
Names
IUPAC name
1-(4-Hydroxy-3-methoxyphenyl) ethane-1,2-diol
Other names
MHPG
Identifiers
  • 534-82-7 Y
3D model (JSmol)
  • Interactive image
  • Interactive image
ChemSpider
  • 10348 Y
KEGG
  • C05594 Y
MeSH Methoxyhydroxyphenylglycol
  • 10805
UNII
  • 98LK01183Z Y
  • InChI=1S/C9H12O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,10-12H,5H2,1H3 Y
    Key: FBWPWWWZWKPJFL-UHFFFAOYSA-N Y
  • InChI=1/C9H12O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,10-12H,5H2,1H3
    Key: FBWPWWWZWKPJFL-UHFFFAOYAR
  • COC1=C(C=CC(=C1)C(CO)O)O
  • Oc1ccc(cc1OC)C(O)CO
Properties
C9H12O4
Molar mass 184.18918
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

Low levels of MHPG in the blood and cerebrospinal fluid are associated with anorexia nervosa and pathological gambling, indicating that norepinephrine may play a role in these behaviors.[2]

Norepinephrine degradation. 3-Methoxy-4-hydroxyphenylglycol is shown at right. Enzymes are shown in boxes.[3]

References edit

  1. ^ Increase in cerebrospinal fluid and plasma levels of 3-methoxy-4- hydroxyphenylglycol in acute stroke T Kanda, K Azuma, F Sakai and Y Tazaki. Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Japan.
  2. ^ "Pharmacologic Approaches to the Treatment of Pathological Gambling". Mental Health eJournal. 1998;3(3). Medscape.
  3. ^ Figure 11-4 in: Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 978-0-443-06911-6.

methoxy, hydroxyphenylglycol, mhpg, mopeg, metabolite, norepinephrine, degradation, brain, principal, norepinephrine, metabolite, released, into, blood, cerebrospinal, fluid, blood, sample, therefore, indication, recent, sympathetic, nervous, system, activity,. 3 Methoxy 4 hydroxyphenylglycol MHPG MOPEG is a metabolite of norepinephrine degradation In the brain it is the principal norepinephrine metabolite It is released into the blood and cerebrospinal fluid 1 and a blood sample of it may therefore be an indication of recent sympathetic nervous system activity 3 Methoxy 4 hydroxyphenylglycol Names IUPAC name 1 4 Hydroxy 3 methoxyphenyl ethane 1 2 diol Other names MHPG Identifiers CAS Number 534 82 7 Y 3D model JSmol Interactive imageInteractive image ChemSpider 10348 Y KEGG C05594 Y MeSH Methoxyhydroxyphenylglycol PubChem CID 10805 UNII 98LK01183Z Y InChI InChI 1S C9H12O4 c1 13 9 4 6 8 12 5 10 2 3 7 9 11 h2 4 8 10 12H 5H2 1H3 YKey FBWPWWWZWKPJFL UHFFFAOYSA N YInChI 1 C9H12O4 c1 13 9 4 6 8 12 5 10 2 3 7 9 11 h2 4 8 10 12H 5H2 1H3Key FBWPWWWZWKPJFL UHFFFAOYAR SMILES COC1 C C CC C1 C CO O OOc1ccc cc1OC C O CO Properties Chemical formula C9H12O4 Molar mass 184 18918 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references Low levels of MHPG in the blood and cerebrospinal fluid are associated with anorexia nervosa and pathological gambling indicating that norepinephrine may play a role in these behaviors 2 Norepinephrine degradation 3 Methoxy 4 hydroxyphenylglycol is shown at right Enzymes are shown in boxes 3 References edit Increase in cerebrospinal fluid and plasma levels of 3 methoxy 4 hydroxyphenylglycol in acute stroke T Kanda K Azuma F Sakai and Y Tazaki Department of Internal Medicine School of Medicine Kitasato University Sagamihara Japan Pharmacologic Approaches to the Treatment of Pathological Gambling Mental Health eJournal 1998 3 3 Medscape Figure 11 4 in Rod Flower Humphrey P Rang Maureen M Dale Ritter James M 2007 Rang amp Dale s pharmacology Edinburgh Churchill Livingstone ISBN 978 0 443 06911 6 Retrieved from https en wikipedia org w index php title 3 Methoxy 4 hydroxyphenylglycol amp oldid 1105102521, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.