3β-(p-Fluorobenzoyloxy)tropane, (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 4-fluorobenzoic acid ester, 4-fluorotropacocaine, 3-Pseudotropyl-4-fluorobenzoate, 3-pseudotropyl-4-fluorobenzoate, pFBT) is a tropane derivative drug which acts as a local anaesthetic, having around 30% the stimulant potency of cocaine but around the same potency as a local anaesthetic.[citation needed] It has been investigated as a potential radiolabelled agent for studying receptor binding,[1] but was not adopted for this application. The main application for fluorotropacocaine, however, has been as a designer druganalogue of cocaine, first detected by the EMCDDA in 2008,[2][3] and subsequently sold as an ingredient of various "bath salt" powder products, usually mixed in combination with other stimulant drugs such as caffeine, dimethocaine, desoxypipradrol or substituted cathinone derivatives.[4]
^Ali M. Emran. New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, 1991. p84. ISBN0-306-44035-0
^Wohlfarth A, Weinmann W (May 2010). "Bioanalysis of new designer drugs". Bioanalysis. 2 (5): 965–79. doi:10.4155/bio.10.32. PMID 21083227.
^Kavanagh P, Angelov D, O'Brien J, Fox J, O'Donnell C, Christie R, et al. (January 2012). "The syntheses and characterization 3β-(4-fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3α isomer". Drug Testing and Analysis. 4 (1): 33–8. doi:10.1002/dta.362. PMID 22102564.
^Reitzel LA, Dalsgaard PW, Müller IB, Cornett C (May 2012). "Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish internet company". Drug Testing and Analysis. 4 (5): 342–54. doi:10.1002/dta.358. PMID 22102551.
January 01, 1970
fluorobenzoyloxy, tropane, fluorobenzoyloxy, tropane, methyl, azabicyclo, fluorobenzoic, acid, ester, fluorotropacocaine, pseudotropyl, fluorobenzoate, pseudotropyl, fluorobenzoate, pfbt, tropane, derivative, drug, which, acts, local, anaesthetic, having, arou. 3b p Fluorobenzoyloxy tropane 8 Methyl 8 azabicyclo 3 2 1 oct 3 yl 4 fluorobenzoic acid ester 4 fluorotropacocaine 3 Pseudotropyl 4 fluorobenzoate 3 pseudotropyl 4 fluorobenzoate pFBT is a tropane derivative drug which acts as a local anaesthetic having around 30 the stimulant potency of cocaine but around the same potency as a local anaesthetic citation needed It has been investigated as a potential radiolabelled agent for studying receptor binding 1 but was not adopted for this application The main application for fluorotropacocaine however has been as a designer drug analogue of cocaine first detected by the EMCDDA in 2008 2 3 and subsequently sold as an ingredient of various bath salt powder products usually mixed in combination with other stimulant drugs such as caffeine dimethocaine desoxypipradrol or substituted cathinone derivatives 4 3 p Fluorobenzoyloxy tropaneClinical dataRoutes ofadministrationinsufflatedLegal statusLegal statusDE Anlage II Authorized trade only not prescriptible IdentifiersIUPAC name 1R 5S 8 methyl 8 azabicyclo 3 2 1 octan 3 yl 4 fluorobenzoateCAS Number172883 97 5 YPubChem CID5147770ChemSpider4321292 YUNIIMQP3G94388Chemical and physical dataFormulaC 15H 18F N O 2Molar mass263 312 g mol 13D model JSmol Interactive imageSMILES CN1C2CC OC C3 CC C F C C3 O CC1CC2InChI InChI 1S C15H18FNO2 c1 17 12 6 7 13 17 9 14 8 12 19 15 18 10 2 4 11 16 5 3 10 h2 5 12 14H 6 9H2 1H3 YKey YXDFSLSXLYAAPF UHFFFAOYSA N Y N Y what is this verify See also editHygrine 4 Fluorococaine RTI 160 Tropacocaine List of cocaine analoguesReferences edit Ali M Emran New Trends in Radiopharmaceutical Synthesis Quality Assurance and Regulatory Control Springer 1991 p84 ISBN 0 306 44035 0 Wohlfarth A Weinmann W May 2010 Bioanalysis of new designer drugs Bioanalysis 2 5 965 79 doi 10 4155 bio 10 32 PMID 21083227 Kavanagh P Angelov D O Brien J Fox J O Donnell C Christie R et al January 2012 The syntheses and characterization 3b 4 fluorobenzoyloxy tropane fluorotropacocaine and its 3a isomer Drug Testing and Analysis 4 1 33 8 doi 10 1002 dta 362 PMID 22102564 Reitzel LA Dalsgaard PW Muller IB Cornett C May 2012 Identification of ten new designer drugs by GC MS UPLC QTOF MS and NMR as part of a police investigation of a Danish internet company Drug Testing and Analysis 4 5 342 54 doi 10 1002 dta 358 PMID 22102551 Retrieved from https en wikipedia org w index php title 3 p Fluorobenzoyloxy tropane amp oldid 1209715403, wikipedia, wiki, book, books, library,
