This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.[6]
Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.[7] The gene for CCL19 is located on human chromosome 9.[8] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptorCCR7.[7] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,[9][10] CCR7+ central-memory T-Cells.[11]
References
^ abcGRCh38: Ensembl release 89: ENSG00000172724 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000118633 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^ abYoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939.
^Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature. 416 (6876): 94–9. Bibcode:2002Natur.416...94R. doi:10.1038/416094a. PMID 11882900. S2CID 4403093.
^Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469. S2CID 443455.
Further reading
Weber C, Koenen RR (2006). "Fine-tuning leukocyte responses: towards a chemokine 'interactome'". Trends Immunol. 27 (6): 268–73. doi:10.1016/j.it.2006.04.002. PMID 16678487.
Rossi DL, Vicari AP, Franz-Bacon K, et al. (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939.
Nagira M, Imai T, Hieshima K, et al. (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". J. Biol. Chem. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
Kim CH, Pelus LM, White JR, et al. (1998). "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells". J. Immunol. 160 (5): 2418–24. PMID 9498785.
Yanagihara S, Komura E, Nagafune J, et al. (1998). "EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation". J. Immunol. 161 (6): 3096–102. PMID 9743376.
Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
Annunziato F, Romagnani P, Cosmi L, et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057.
Ueno T, Hara K, Willis MS, et al. (2002). "Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus". Immunity. 16 (2): 205–18. doi:10.1016/S1074-7613(02)00267-4. PMID 11869682.
Phillips R, Ager A (2002). "Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells". Eur. J. Immunol. 32 (3): 837–47. doi:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q. PMID 11870628. S2CID 41323072.
Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes". Blood. 99 (8): 2977–84. doi:10.1182/blood.V99.8.2977. PMID 11929789.
Townson JR, Nibbs RJ (2002). "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR". Eur. J. Immunol. 32 (5): 1230–41. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810. S2CID 21911348.
Page G, Lebecque S, Miossec P (2002). "Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium". J. Immunol. 168 (10): 5333–41. doi:10.4049/jimmunol.168.10.5333. PMID 11994492.
Katou F, Ohtani H, Nakayama T, et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin". J. Pathol. 199 (1): 98–106. doi:10.1002/path.1255. PMID 12474232. S2CID 25424987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Scandella E, Men Y, Legler DF, et al. (2004). "CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2". Blood. 103 (5): 1595–601. doi:10.1182/blood-2003-05-1643. PMID 14592837.
Corcione A, Arduino N, Ferretti E, et al. (2004). "CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells". Clin. Cancer Res. 10 (3): 964–71. doi:10.1158/1078-0432.CCR-1182-3. PMID 14871974.
Daikoku N, Kitaya K, Nakayama T, et al. (2004). "Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle". Fertil. Steril. 81 Suppl 1: 876–81. doi:10.1016/j.fertnstert.2003.09.036. PMID 15019823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Paoletti S, Petkovic V, Sebastiani S, et al. (2005). "A rich chemokine environment strongly enhances leukocyte migration and activities". Blood. 105 (9): 3405–12. doi:10.1182/blood-2004-04-1648. PMID 15546958.
External links
Human CCL19 genome location and CCL19 gene details page in the UCSC Genome Browser.
March 13, 2023
ccl19, chemokine, motif, ligand, protein, that, humans, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes2mp1identifiersaliases, ckb11, mip3b, scya19, motif, chemokine, ligand, 19external, idsomim, 602227, 5434459, homologene. Chemokine C C motif ligand 19 CCL19 is a protein that in humans is encoded by the CCL19 gene 5 6 CCL19Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes2MP1IdentifiersAliasesCCL19 CKb11 ELC MIP 3b MIP3B SCYA19 C C motif chemokine ligand 19External IDsOMIM 602227 MGI 5434459 HomoloGene 4569 GeneCards CCL19Gene location Human Chr Chromosome 9 human 1 Band9p13 3Start34 689 570 bp 1 End34 691 276 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 A5 4Start42 070 757 bp 2 End42 072 779 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inappendixlymph nodegallbladderthymusrectumleft coronary arteryright coronary arterythymusgastric mucosaright lobe of thyroid glandTop expressed inspleenadrenal glandsuperior frontal gyrusthymuslipzone of skinkidneyislet of Langerhanscerebellar cortexwhite adipose tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionCCR10 chemokine receptor binding cytokine activity chemokine receptor binding CCR7 chemokine receptor binding chemokine activity CCR chemokine receptor binding protein bindingCellular componentextracellular region intracellular anatomical structure extracellular spaceBiological processrelease of sequestered calcium ion into cytosol positive regulation of receptor mediated endocytosis positive regulation of protein kinase B signaling positive regulation of cell motility positive regulation of dendritic cell dendrite assembly positive regulation of interleukin 12 production regulation of cell projection assembly monocyte chemotaxis positive regulation of T helper 1 cell differentiation chemokine mediated signaling pathway response to nitric oxide cellular response to tumor necrosis factor T cell costimulation response to virus cellular calcium ion homeostasis cell maturation myeloid dendritic cell chemotaxis positive regulation of JNK cascade dendritic cell chemotaxis positive regulation of phosphatidylinositol 3 kinase activity chemotaxis cell communication positive regulation of endocytosis positive regulation of GTPase activity response to prostaglandin E positive regulation of dendritic cell antigen processing and presentation positive regulation of chemotaxis cellular response to interleukin 1 positive regulation of T cell proliferation immune response positive regulation of ERK1 and ERK2 cascade establishment of T cell polarity positive regulation of glycoprotein biosynthetic process cellular response to interferon gamma positive regulation of tumor necrosis factor production positive regulation of I kappaB kinase NF kappaB signaling lymphocyte chemotaxis positive regulation of neutrophil chemotaxis inflammatory response immunological synapse formation mature conventional dendritic cell differentiation positive regulation of protein kinase activity antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein coupled receptor signaling pathway negative regulation of dendritic cell apoptotic process cytokine mediated signaling pathway positive regulation of NIK NF kappaB signaling neutrophil chemotaxisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6363100861647EnsemblENSG00000172724ENSMUSG00000118633UniProtQ99731n aRefSeq mRNA NM 006274XM 006538413RefSeq protein NP 006265n aLocation UCSC Chr 9 34 69 34 69 MbChr 4 42 07 42 07 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is one of several CC cytokine genes clustered on the p arm of chromosome 9 Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes The CC cytokines are proteins characterized by two adjacent cysteines The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing It also plays an important role in trafficking of T cells in thymus and in T cell and B cell migration to secondary lymphoid organs It specifically binds to chemokine receptor CCR7 6 Chemokine C C motif ligand 19 CCL19 is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine ELC and macrophage inflammatory protein 3 beta MIP 3 beta CCL19 is expressed abundantly in thymus and lymph nodes with moderate levels in trachea and colon and low levels in stomach small intestine lung kidney and spleen 7 The gene for CCL19 is located on human chromosome 9 8 This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7 7 It attracts certain cells of the immune system including dendritic cells and antigen engaged B cells 9 10 CCR7 central memory T Cells 11 References Edit a b c GRCh38 Ensembl release 89 ENSG00000172724 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000118633 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yoshida R Imai T Hieshima K Kusuda J Baba M Kitaura M Nishimura M Kakizaki M Nomiyama H Yoshie O Jul 1997 Molecular cloning of a novel human CC chemokine EBI1 ligand chemokine that is a specific functional ligand for EBI1 CCR7 J Biol Chem 272 21 13803 9 doi 10 1074 jbc 272 21 13803 PMID 9153236 a b Entrez Gene CCL19 chemokine C C motif ligand 19 a b Yoshida R Imai T Hieshima K Kusuda J Baba M Kitaura M Nishimura M Kakizaki M Nomiyama H Yoshie O 1997 Molecular cloning of a novel human CC chemokine EBI1 ligand chemokine that is a specific functional ligand for EBI1 CCR7 J Biol Chem 272 21 13803 9 doi 10 1074 jbc 272 21 13803 PMID 9153236 Rossi DL Vicari AP Franz Bacon K McClanahan TK Zlotnik A 1997 Identification through bioinformatics of two new macrophage proinflammatory human chemokines MIP 3alpha and MIP 3beta J Immunol 158 3 1033 6 PMID 9013939 Robbiani DF Finch RA Jager D Muller WA Sartorelli AC Randolph GJ 2000 The leukotriene C 4 transporter MRP1 regulates CCL19 MIP 3beta ELC dependent mobilization of dendritic cells to lymph nodes Cell 103 5 757 68 doi 10 1016 S0092 8674 00 00179 3 PMID 11114332 S2CID 15592251 Reif K Ekland EH Ohl L Nakano H Lipp M Forster R Cyster JG 2002 Balanced responsiveness to chemoattractants from adjacent zones determines B cell position Nature 416 6876 94 9 Bibcode 2002Natur 416 94R doi 10 1038 416094a PMID 11882900 S2CID 4403093 Bromley SK Thomas SY Luster AD 2005 Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics Nat Immunol 6 9 895 901 doi 10 1038 ni1240 PMID 16116469 S2CID 443455 Further reading EditWeber C Koenen RR 2006 Fine tuning leukocyte responses towards a chemokine interactome Trends Immunol 27 6 268 73 doi 10 1016 j it 2006 04 002 PMID 16678487 Rossi DL Vicari AP Franz Bacon K et al 1997 Identification through bioinformatics of two new macrophage proinflammatory human chemokines MIP 3alpha and MIP 3beta J Immunol 158 3 1033 6 PMID 9013939 Nagira M Imai T Hieshima K et al 1997 Molecular cloning of a novel human CC chemokine secondary lymphoid tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 J Biol Chem 272 31 19518 24 doi 10 1074 jbc 272 31 19518 PMID 9235955 Kim CH Pelus LM White JR et al 1998 CK beta 11 macrophage inflammatory protein 3 beta EBI1 ligand chemokine is an efficacious chemoattractant for T and B cells J Immunol 160 5 2418 24 PMID 9498785 Yanagihara S Komura E Nagafune J et al 1998 EBI1 CCR7 is a new member of dendritic cell chemokine receptor that is up regulated upon maturation J Immunol 161 6 3096 102 PMID 9743376 Gosling J Dairaghi DJ Wang Y et al 2000 Cutting edge identification of a novel chemokine receptor that binds dendritic cell and T cell active chemokines including ELC SLC and TECK J Immunol 164 6 2851 6 doi 10 4049 jimmunol 164 6 2851 PMID 10706668 Annunziato F Romagnani P Cosmi L et al 2000 Macrophage derived chemokine and EBI1 ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells possible implications for negative selection J Immunol 165 1 238 46 doi 10 4049 jimmunol 165 1 238 PMID 10861057 Ueno T Hara K Willis MS et al 2002 Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus Immunity 16 2 205 18 doi 10 1016 S1074 7613 02 00267 4 PMID 11869682 Phillips R Ager A 2002 Activation of pertussis toxin sensitive CXCL12 SDF 1 receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells Eur J Immunol 32 3 837 47 doi 10 1002 1521 4141 200203 32 3 lt 837 AID IMMU837 gt 3 0 CO 2 Q PMID 11870628 S2CID 41323072 Till KJ Lin K Zuzel M Cawley JC 2002 The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes Blood 99 8 2977 84 doi 10 1182 blood V99 8 2977 PMID 11929789 Townson JR Nibbs RJ 2002 Characterization of mouse CCX CKR a receptor for the lymphocyte attracting chemokines TECK mCCL25 SLC mCCL21 and MIP 3beta mCCL19 comparison to human CCX CKR Eur J Immunol 32 5 1230 41 doi 10 1002 1521 4141 200205 32 5 lt 1230 AID IMMU1230 gt 3 0 CO 2 L PMID 11981810 S2CID 21911348 Page G Lebecque S Miossec P 2002 Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ correlation with selective chemokine expression in rheumatoid synovium J Immunol 168 10 5333 41 doi 10 4049 jimmunol 168 10 5333 PMID 11994492 Katou F Ohtani H Nakayama T et al 2003 Differential expression of CCL19 by DC Lamp mature dendritic cells in human lymph node versus chronically inflamed skin J Pathol 199 1 98 106 doi 10 1002 path 1255 PMID 12474232 S2CID 25424987 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Scandella E Men Y Legler DF et al 2004 CCL19 CCL21 triggered signal transduction and migration of dendritic cells requires prostaglandin E2 Blood 103 5 1595 601 doi 10 1182 blood 2003 05 1643 PMID 14592837 Corcione A Arduino N Ferretti E et al 2004 CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells Clin Cancer Res 10 3 964 71 doi 10 1158 1078 0432 CCR 1182 3 PMID 14871974 Daikoku N Kitaya K Nakayama T et al 2004 Expression of macrophage inflammatory protein 3beta in human endometrium throughout the menstrual cycle Fertil Steril 81 Suppl 1 876 81 doi 10 1016 j fertnstert 2003 09 036 PMID 15019823 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Paoletti S Petkovic V Sebastiani S et al 2005 A rich chemokine environment strongly enhances leukocyte migration and activities Blood 105 9 3405 12 doi 10 1182 blood 2004 04 1648 PMID 15546958 External links EditHuman CCL19 genome location and CCL19 gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title CCL19 amp oldid 1116740453, wikipedia, wiki, book, books, library,
