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Wikipedia

Y box binding protein 1

January 01, 1970

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[5]

YBX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDsOMIM: 154030 MGI: 99146 HomoloGene: 88707 GeneCards: YBX1
Orthologs
SpeciesHumanMouse
Entrez

4904

22608

Ensembl

ENSG00000065978

ENSMUSG00000028639

UniProt

P67809

P62960

RefSeq (mRNA)

NM_004559

NM_011732

RefSeq (protein)

NP_004550

NP_035862

Location (UCSC)Chr 1: 42.68 – 42.7 MbChr 4: 119.14 – 119.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance edit

YBX1 is a potential drug target in cancer therapy.[6] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[6] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions edit

Y box binding protein 1 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065978 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028639 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: YBX1 Y box binding protein 1".
  6. ^ a b Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 (Suppl 2): 187–90. doi:10.1007/s00292-008-1030-2. PMID 18773210.
  7. ^ a b Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035.
  8. ^ Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi:10.1074/jbc.M001538200. PMID 10906122.
  9. ^ Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene. 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. PMID 11175333.
  10. ^ Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
  11. ^ Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.
  12. ^ Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.

Further reading edit

  • Kolluri R, Torrey TA, Kinniburgh AJ (1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif". Nucleic Acids Res. 20 (1): 111–6. doi:10.1093/nar/20.1.111. PMC 5356827. PMID 1738588.
  • Kolluri R, Kinniburgh AJ (1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein". Nucleic Acids Res. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMC 328725. PMID 1891370.
  • Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
  • Didier DK, Schiffenbauer J, Woulfe SL, et al. (1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. Bibcode:1988PNAS...85.7322D. doi:10.1073/pnas.85.19.7322. PMC 282178. PMID 3174636.
  • Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
  • Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. doi:10.1128/mcb.15.9.5092. PMC 230756. PMID 7651426.
  • Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. Bibcode:1995PNAS...92.1087C. doi:10.1073/pnas.92.4.1087. PMC 42642. PMID 7862639.
  • Horwitz EM, Maloney KA, Ley TJ (1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes". J. Biol. Chem. 269 (19): 14130–9. doi:10.1016/S0021-9258(17)36764-9. PMID 8188694.
  • Kashanchi F, Duvall JF, Dittmer J, et al. (1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression". J. Virol. 68 (1): 561–5. doi:10.1128/JVI.68.1.561-565.1994. PMC 236322. PMID 8254772.
  • Makino Y, Ohga T, Toh S, et al. (1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter". Nucleic Acids Res. 24 (10): 1873–8. doi:10.1093/nar/24.10.1873. PMC 145870. PMID 8657568.
  • Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
  • Koike K, Uchiumi T, Ohga T, et al. (1998). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation". FEBS Lett. 417 (3): 390–4. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758. S2CID 24656107.
  • Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–7. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420.
  • Sawaya BE, Khalili K, Amini S (1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat". J. Gen. Virol. 79. ( Pt 2) (2): 239–46. doi:10.1099/0022-1317-79-2-239. PMID 9472608.
  • Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription". J. Biol. Chem. 273 (49): 32957–65. doi:10.1074/jbc.273.49.32957. PMID 9830047.
  • Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
  • Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells". Mol. Cell. Biol. 19 (4): 2712–23. doi:10.1128/mcb.19.4.2712. PMC 84064. PMID 10082537.
  • Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
  • Safak M, Gallia GL, Ansari SA, Khalili K (1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen". J. Virol. 73 (12): 10146–57. doi:10.1128/JVI.73.12.10146-10157.1999. PMC 113067. PMID 10559330.
  • Ansari SA, Safak M, Gallia GL, et al. (1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity". J. Gen. Virol. 80. ( Pt 10) (10): 2629–38. doi:10.1099/0022-1317-80-10-2629. PMID 10573156.
  • Basaki Y, Hosoi F, Oda Y, et al. (2007). "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells". Oncogene. 26 (19): 2736–46. doi:10.1038/sj.onc.1210084. PMID 17072343.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
binding, protein, also, known, transcription, factor, nuclease, sensitive, element, binding, protein, protein, that, humans, encoded, ybx1, gene, ybx1available, structurespdbortholog, search, pdbe, rcsblist, codes1h95identifiersaliasesybx1, csda2, csdb, dbpb, . Y box binding protein 1 also known as Y box transcription factor or nuclease sensitive element binding protein 1 is a protein that in humans is encoded by the YBX1 gene 5 YBX1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1H95IdentifiersAliasesYBX1 BP 8 CSDA2 CSDB DBPB MDR NF1 NSEP 1 NSEP1 YB 1 YB1 CBF A EFI A Y box binding protein 1External IDsOMIM 154030 MGI 99146 HomoloGene 88707 GeneCards YBX1Gene location Human Chr Chromosome 1 human 1 Band1p34 2Start42 682 418 bp 1 End42 703 805 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D2 1Start119 135 178 bp 2 End119 151 801 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceAchilles tendongastrocnemius muscleskeletal muscle tissueleft ventriclestromal cell of endometriumsmooth muscle tissuepopliteal arteryappendixleft coronary arteryTop expressed inprimitive streakabdominal wallmedial ganglionic eminenceseminiferous tubulemaxillary prominencesciatic nervesomitePaneth cellinterventricular septumcrypt of lieberkuhn of small intestineMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding DNA binding transcription factor activity DNA binding transcription activator activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA binding protein binding RNA binding nucleic acid binding GTPase binding double stranded DNA binding single stranded DNA binding chromatin binding DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm CRD mediated mRNA stability complex nuclear membrane intracellular membrane bounded organelle U12 type spliceosomal complex nucleoplasm extracellular region cytoplasmic stress granule extracellular exosome nucleus histone pre mRNA 3 end processing complex cytosol ribonucleoprotein complexBiological processCRD mediated mRNA stabilization mRNA splicing via spliceosome regulation of transcription DNA templated mRNA processing transcription by RNA polymerase II protein localization to cytoplasmic stress granule transcription DNA templated positive regulation of cell division positive regulation of transcription by RNA polymerase II in utero embryonic development RNA splicing negative regulation of striated muscle cell differentiation negative regulation of transcription by RNA polymerase II Notch signaling pathway cellular response to interleukin 7Sources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez490422608EnsemblENSG00000065978ENSMUSG00000028639UniProtP67809P62960RefSeq mRNA NM 004559NM 011732RefSeq protein NP 004550NP 035862Location UCSC Chr 1 42 68 42 7 MbChr 4 119 14 119 15 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Clinical significance 2 Interactions 3 References 4 Further reading 5 External linksClinical significance editYBX1 is a potential drug target in cancer therapy 6 YB 1 helps the replication of adenovirus type 5 a commonly used vector in gene therapy 6 Thus YB 1 can cause an oncolytic effect in YB 1 positive cancer cells treated with adenoviruses Interactions editY box binding protein 1 has been shown to interact with ANKRD2 7 CTCF 8 P53 7 9 PCNA 10 RBBP6 11 and SFRS9 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000065978 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028639 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene YBX1 Y box binding protein 1 a b Lage H Surowiak P Holm PS November 2008 YB 1 as a potential target in cancer therapy Pathologe in German 29 Suppl 2 187 90 doi 10 1007 s00292 008 1030 2 PMID 18773210 a b Kojic S Medeot E Guccione E Krmac H Zara I Martinelli V Valle G Faulkner G 2004 The Ankrd2 protein a link between the sarcomere and the nucleus in skeletal muscle J Mol Biol 339 2 313 25 doi 10 1016 j jmb 2004 03 071 PMID 15136035 Chernukhin IV Shamsuddin S Robinson AF Carne AF Paul A El Kady AI Lobanenkov VV Klenova EM 2000 Physical and functional interaction between two pluripotent proteins the Y box DNA RNA binding factor YB 1 and the multivalent zinc finger factor CTCF J Biol Chem 275 38 29915 21 doi 10 1074 jbc M001538200 PMID 10906122 Okamoto T Izumi H Imamura T Takano H Ise T Uchiumi T Kuwano M Kohno K 2000 Direct interaction of p53 with the Y box binding protein YB 1 a mechanism for regulation of human gene expression Oncogene 19 54 6194 202 doi 10 1038 sj onc 1204029 PMID 11175333 Ise T Nagatani G Imamura T Kato K Takano H Nomoto M Izumi H Ohmori H Okamoto T Ohga T Uchiumi T Kuwano M Kohno K 1999 Transcription factor Y box binding protein 1 binds preferentially to cisplatin modified DNA and interacts with proliferating cell nuclear antigen Cancer Res 59 2 342 6 PMID 9927044 Chibi M Meyer M Skepu A G Rees DJ Moolman Smook JC Pugh DJ 2008 RBBP6 interacts with multifunctional protein YB 1 through its RING finger domain leading to ubiquitination and proteosomal degradation of YB 1 J Mol Biol 384 4 908 16 doi 10 1016 j jmb 2008 09 060 PMID 18851979 Raffetseder U Frye B Rauen T Jurchott K Royer HD Jansen PL Mertens PR 2003 Splicing factor SRp30c interaction with Y box protein 1 confers nuclear YB 1 shuttling and alternative splice site selection J Biol Chem 278 20 18241 8 doi 10 1074 jbc M212518200 PMID 12604611 Further reading editKolluri R Torrey TA Kinniburgh AJ 1992 A CT promoter element binding protein definition of a double strand and a novel single strand DNA binding motif Nucleic Acids Res 20 1 111 6 doi 10 1093 nar 20 1 111 PMC 5356827 PMID 1738588 Kolluri R Kinniburgh AJ 1991 Full length cDNA sequence encoding a nuclease sensitive element DNA binding protein Nucleic Acids Res 19 17 4771 doi 10 1093 nar 19 17 4771 PMC 328725 PMID 1891370 Sakura H Maekawa T Imamoto F et al 1989 Two human genes isolated by a novel method encode DNA binding proteins containing a common region of homology Gene 73 2 499 507 doi 10 1016 0378 1119 88 90514 8 PMID 2977358 Didier DK Schiffenbauer J Woulfe SL et al 1988 Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box Proc Natl Acad Sci U S A 85 19 7322 6 Bibcode 1988PNAS 85 7322D doi 10 1073 pnas 85 19 7322 PMC 282178 PMID 3174636 Kudo S Mattei MG Fukuda M 1995 Characterization of the gene for dbpA a family member of the nucleic acid binding proteins containing a cold shock domain Eur J Biochem 231 1 72 82 doi 10 1111 j 1432 1033 1995 tb20672 x PMID 7628487 Lloberas J Maki RA Celada A 1995 Repression of major histocompatibility complex I A beta gene expression by dbpA and dbpB mYB 1 proteins Mol Cell Biol 15 9 5092 9 doi 10 1128 mcb 15 9 5092 PMC 230756 PMID 7651426 Chen NN Chang CF Gallia GL et al 1995 Cooperative action of cellular proteins YB 1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element Proc Natl Acad Sci U S A 92 4 1087 91 Bibcode 1995PNAS 92 1087C doi 10 1073 pnas 92 4 1087 PMC 42642 PMID 7862639 Horwitz EM Maloney KA Ley TJ 1994 A human protein containing a cold shock domain binds specifically to H DNA upstream from the human gamma globin genes J Biol Chem 269 19 14130 9 doi 10 1016 S0021 9258 17 36764 9 PMID 8188694 Kashanchi F Duvall JF Dittmer J et al 1994 Involvement of transcription factor YB 1 in human T cell lymphotropic virus type I basal gene expression J Virol 68 1 561 5 doi 10 1128 JVI 68 1 561 565 1994 PMC 236322 PMID 8254772 Makino Y Ohga T Toh S et al 1996 Structural and functional analysis of the human Y box binding protein YB 1 gene promoter Nucleic Acids Res 24 10 1873 8 doi 10 1093 nar 24 10 1873 PMC 145870 PMID 8657568 Funke B Zuleger B Benavente R et al 1996 The mouse poly C binding protein exists in multiple isoforms and interacts with several RNA binding proteins Nucleic Acids Res 24 19 3821 8 doi 10 1093 nar 24 19 3821 PMC 146158 PMID 8871564 Koike K Uchiumi T Ohga T et al 1998 Nuclear translocation of the Y box binding protein by ultraviolet irradiation FEBS Lett 417 3 390 4 doi 10 1016 S0014 5793 97 01296 9 PMID 9409758 S2CID 24656107 Toh S Nakamura T Ohga T et al 1998 Genomic organization of the human Y box protein YB 1 gene Gene 206 1 93 7 doi 10 1016 S0378 1119 97 00570 2 PMID 9461420 Sawaya BE Khalili K Amini S 1998 Transcription of the human immunodeficiency virus type 1 HIV 1 promoter in central nervous system cells effect of YB 1 on expression of the HIV 1 long terminal repeat J Gen Virol 79 Pt 2 2 239 46 doi 10 1099 0022 1317 79 2 239 PMID 9472608 Mertens PR Alfonso Jaume MA Steinmann K Lovett DH 1999 A synergistic interaction of transcription factors AP2 and YB 1 regulates gelatinase A enhancer dependent transcription J Biol Chem 273 49 32957 65 doi 10 1074 jbc 273 49 32957 PMID 9830047 Ise T Nagatani G Imamura T et al 1999 Transcription factor Y box binding protein 1 binds preferentially to cisplatin modified DNA and interacts with proliferating cell nuclear antigen Cancer Res 59 2 342 6 PMID 9927044 Safak M Gallia GL Khalili K 1999 Reciprocal interaction between two cellular proteins Puralpha and YB 1 modulates transcriptional activity of JCVCY in glial cells Mol Cell Biol 19 4 2712 23 doi 10 1128 mcb 19 4 2712 PMC 84064 PMID 10082537 Kelm RJ Cogan JG Elder PK et al 1999 Molecular interactions between single stranded DNA binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha actin promoter J Biol Chem 274 20 14238 45 doi 10 1074 jbc 274 20 14238 PMID 10318844 Safak M Gallia GL Ansari SA Khalili K 1999 Physical and functional interaction between the Y box binding protein YB 1 and human polyomavirus JC virus large T antigen J Virol 73 12 10146 57 doi 10 1128 JVI 73 12 10146 10157 1999 PMC 113067 PMID 10559330 Ansari SA Safak M Gallia GL et al 1999 Interaction of YB 1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity J Gen Virol 80 Pt 10 10 2629 38 doi 10 1099 0022 1317 80 10 2629 PMID 10573156 Basaki Y Hosoi F Oda Y et al 2007 Akt dependent nuclear localization of Y box binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells Oncogene 26 19 2736 46 doi 10 1038 sj onc 1210084 PMID 17072343 External links editYBX1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Y box binding protein 1 amp oldid 1175857314, wikipedia, wiki, book, books, library,

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