The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have are critical in tissue homeostasis, embryonic development, and disease.
WNT3A is highly related to the WNT3 gene in sequence and protein function. WNT3A and WNT3 signal similarly through primarily the beta-catenin/Tcf pathway. WNT3A is located in the genome beside the WNT9A gene across many vertebrates. Similarly, the WNT3 gene occurs in the genome beside the WNT9B gene. WNT9A and WNT9B signal through the beta-catenin/Tcf pathway but do not play related roles as WNT3A and WNT3 in the same cellular processes.
Role in Diseaseedit
WNT3A is not linked to particular genetic disorder in humans. Mice that have a genetic mutation in the WNT3A die during early embryogenesis and fail to correctly form axial tissues.[6] Rodent Wnt3a promotes the beta-catenin/Tcf pathway which is tumor inducing and can cause cancer when expressed in particular cell populations.[7]
Role in embryonic developmentedit
Embryonic development is the process where the body plan is created. From studies in vertebrate model systems we can infer the roles of particular genes in human anatomical structures. Wnt3a plays a role in these processes:
Wnt3A patterns a multipotent stem cell population that form neurons, muscles, bones, and cartilage of the torso region. Wnt3a instructs these multipotent stems cells to form muscle, bone, and cartilage progenitors over forming neurons.[8] Wnt3A also regulates the Notch pathway to control the segmentation clock needed for normal torso development [9][10]
Left-Right patterningedit
Wnt3a is in a signaling pathway that activates the gene Nodal which is left side signaling determinant [11]
Intestine - Colonedit
The colon portion of the gastrointestinal tract is completely dependent on Wnt3a and Wnt3a selectively causes the growth of colon progenitors [12]
Wnt3a promotes hematopoietic stem cell self-renewal. Wnt3a is needed for myeloid but not B-lymphoid development at the progenitor level, and affected immature thymocyte differentiation [14]
Brain - Hippocampusedit
Wnt3a is needed for formation of the hippocampus portion of the brain [15]
^ abcGRCh38: Ensembl release 89: ENSG00000154342 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009900 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A".
^Yoshikawa Y, Fujimori T, McMahon AP, Takada S (March 1997). "Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse". Developmental Biology. 183 (2): 234–42. doi:10.1006/dbio.1997.8502. PMID 9126297.
^Pashirzad M, Fiuji H, Khazei M, Moradi-Binabaj M, Ryzhikov M, Shabani M, et al. (October 2019). "Role of Wnt3a in the pathogenesis of cancer, current status and prospective". Molecular Biology Reports. 46 (5): 5609–5616. doi:10.1007/s11033-019-04895-4. PMID 31236761. S2CID 195329662.
^Garriock RJ, Chalamalasetty RB, Kennedy MW, Canizales LC, Lewandoski M, Yamaguchi TP (May 2015). "Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation". Development. 142 (9): 1628–38. doi:10.1242/dev.111922. PMC4419273. PMID 25922526.
^Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG (March 2003). "Wnt3a plays a major role in the segmentation clock controlling somitogenesis". Developmental Cell. 4 (3): 395–406. doi:10.1016/s1534-5807(03)00055-8. PMID 12636920.
^Garriock RJ, Chalamalasetty RB, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP (April 2020). "A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation". Development. 147 (8): dev185108. doi:10.1242/dev.185108. PMC7174843. PMID 32156757.
^Ikeya M, Lee SM, Johnson JE, McMahon AP, Takada S (October 1997). "Wnt signalling required for expansion of neural crest and CNS progenitors". Nature. 389 (6654): 966–70. Bibcode:1997Natur.389..966I. doi:10.1038/40146. PMID 9353119. S2CID 4359867.
^Luis TC, Weerkamp F, Naber BA, Baert MR, de Haas EF, Nikolic T, et al. (January 2009). "Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation". Blood. 113 (3): 546–54. doi:10.1182/blood-2008-06-163774. hdl:1765/19345. PMID 18832654. S2CID 1932170.
^Lee SM, Tole S, Grove E, McMahon AP (February 2000). "A local Wnt-3a signal is required for development of the mammalian hippocampus". Development. 127 (3): 457–67. doi:10.1242/dev.127.3.457. PMID 10631167.
^Uribe-Etxebarria V, García-Gallastegui P, Pérez-Garrastachu M, Casado-Andrés M, Irastorza I, Unda F, et al. (March 2020). "Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells". Cells. 9 (3): E652. doi:10.3390/cells9030652. PMC7140622. PMID 32156036.
Further readingedit
Smolich BD, McMahon JA, McMahon AP, Papkoff J (December 1993). "Wnt family proteins are secreted and associated with the cell surface". Molecular Biology of the Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC275763. PMID 8167409.
Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (May 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Research. 54 (10): 2615–21. PMID 8168088.
Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (October 1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (July 2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". European Journal of Biochemistry. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
Katoh M (February 2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". International Journal of Oncology. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
Katoh M (March 2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster". International Journal of Molecular Medicine. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
Filali M, Cheng N, Abbott D, Leontiev V, Engelhardt JF (September 2002). "Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter". The Journal of Biological Chemistry. 277 (36): 33398–410. doi:10.1074/jbc.M107977200. PMID 12052822.
Hering H, Sheng M (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Hino S, Michiue T, Asashima M, Kikuchi A (April 2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin". The Journal of Biological Chemistry. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
Qiang YW, Endo Y, Rubin JS, Rudikoff S (March 2003). "Wnt signaling in B-cell neoplasia". Oncogene. 22 (10): 1536–45. doi:10.1038/sj.onc.1206239. PMID 12629517.
Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". The EMBO Journal. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC162138. PMID 12805222.
Liu G, Bafico A, Harris VK, Aaronson SA (August 2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor". Molecular and Cellular Biology. 23 (16): 5825–35. doi:10.1128/MCB.23.16.5825-5835.2003. PMC166321. PMID 12897152.
Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM (March 2004). "Regulation of casein kinase I epsilon activity by Wnt signaling". The Journal of Biological Chemistry. 279 (13): 13011–7. doi:10.1074/jbc.M304682200. PMID 14722104.
Zilberberg A, Yaniv A, Gazit A (April 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
Lu W, Yamamoto V, Ortega B, Baltimore D (October 2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084. S2CID 18567677.
Capurro MI, Shi W, Sandal S, Filmus J (December 2005). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth". The Journal of Biological Chemistry. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.
Thrasivoulou C, Millar M, Ahmed A (December 2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways". The Journal of Biological Chemistry. 288 (50): 35651–9. doi:10.1074/jbc.M112.437913. PMC3861617. PMID 24158438.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
wnt3a, protein, protein, that, humans, encoded, gene, identifiersaliases, family, member, 3aexternal, idsomim, 606359, 98956, homologene, 22528, genecards, gene, location, human, chromosome, human, band1q42, 13start228, end228, gene, location, mouse, chromosom. Protein Wnt 3a is a protein that in humans is encoded by the WNT3A gene 5 WNT3AIdentifiersAliasesWNT3A Wnt family member 3AExternal IDsOMIM 606359 MGI 98956 HomoloGene 22528 GeneCards WNT3AGene location Human Chr Chromosome 1 human 1 Band1q42 13Start228 006 998 bp 1 End228 061 271 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 B1 3 11 37 17 cMStart59 138 859 bp 2 End59 181 578 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentaright lungupper lobe of left lungskin of abdomensalivary glandminor salivary glandsprostatevaginathymuskidneyTop expressed inurethramale urethraejaculatory ductfemale urethravaginaprimitive streakmolarpretectal areacorneal stromasomiteMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein domain specific binding signaling receptor binding co receptor binding frizzled binding protein binding transcription coactivator activity receptor ligand activityCellular componentendocytic vesicle membrane endoplasmic reticulum lumen extracellular region cell surface extracellular exosome Wnt Frizzled LRP5 6 complex early endosome membrane plasma membrane Golgi lumen presynapse extracellular space synapse glutamatergic synapseBiological processsomitogenesis cellular response to retinoic acid hemopoiesis positive regulation of protein phosphorylation Wnt signaling pathway involved in forebrain neuroblast division positive regulation of skeletal muscle tissue development positive regulation of receptor internalization axis elongation involved in somitogenesis positive regulation of collateral sprouting in absence of injury mammary gland development platelet activation heart looping positive regulation of cysteine type endopeptidase activity involved in apoptotic process positive regulation of protein localization to plasma membrane cardiac muscle cell fate commitment mesoderm development cell proliferation in forebrain positive regulation of mesodermal cell fate specification negative regulation of fat cell differentiation canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment regulation of microtubule cytoskeleton organization negative regulation of dopaminergic neuron differentiation cell proliferation in midbrain in utero embryonic development negative regulation of axon extension involved in axon guidance positive regulation of peptidyl serine phosphorylation positive regulation of transcription DNA templated regulation of axonogenesis positive regulation of B cell proliferation post anal tail morphogenesis positive regulation of cardiac muscle cell differentiation negative regulation of neuron projection development paraxial mesodermal cell fate commitment negative regulation of neurogenesis positive regulation of protein tyrosine kinase activity positive regulation of DNA binding transcription factor activity extracellular matrix organization positive regulation of neural precursor cell proliferation synaptic vesicle recycling osteoblast differentiation skeletal muscle cell differentiation COP9 signalosome assembly dorsal ventral neural tube patterning positive regulation of protein binding platelet aggregation midbrain development positive regulation of protein kinase activity positive regulation of cell cell adhesion mediated by cadherin positive regulation of hepatocyte proliferation neurogenesis spinal cord association neuron differentiation axonogenesis positive regulation of cytokine production positive regulation of dermatome development somatic stem cell division positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation axon guidance multicellular organism development determination of left right symmetry inner ear morphogenesis positive regulation of cell population proliferation regulation of cell differentiation hippocampus development negative regulation of heart induction by canonical Wnt signaling pathway positive regulation of transcription by RNA polymerase II anterior posterior pattern specification Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation beta catenin destruction complex disassembly neuron differentiation Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of gene expression calcium ion transmembrane transport via low voltage gated calcium channel presynapse assembly negative regulation of neuron death positive regulation of core promoter binding regulation of RNA biosynthetic process regulation of signaling receptor activity cell population proliferation canonical Wnt signaling pathway secondary palate development cell fate commitment modulation of chemical synaptic transmission regulation of synapse organization postsynapse to nucleus signaling pathway regulation of presynapse assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8978022416EnsemblENSG00000154342ENSMUSG00000009900UniProtP56704P27467RefSeq mRNA NM 033131NM 009522RefSeq protein NP 149122NP 033548Location UCSC Chr 1 228 01 228 06 MbChr 11 59 14 59 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The WNT gene family consists of structurally related genes that encode secreted signaling proteins These proteins have are critical in tissue homeostasis embryonic development and disease Contents 1 Signaling and Related Genes 2 Role in Disease 3 Role in embryonic development 3 1 Body plan Torso 3 2 Left Right patterning 3 3 Intestine Colon 3 4 Neural crest 3 5 Blood cells 3 6 Brain Hippocampus 3 7 Teeth 4 References 5 Further readingSignaling and Related Genes editWNT3A is highly related to the WNT3 gene in sequence and protein function WNT3A and WNT3 signal similarly through primarily the beta catenin Tcf pathway WNT3A is located in the genome beside the WNT9A gene across many vertebrates Similarly the WNT3 gene occurs in the genome beside the WNT9B gene WNT9A and WNT9B signal through the beta catenin Tcf pathway but do not play related roles as WNT3A and WNT3 in the same cellular processes Role in Disease editWNT3A is not linked to particular genetic disorder in humans Mice that have a genetic mutation in the WNT3A die during early embryogenesis and fail to correctly form axial tissues 6 Rodent Wnt3a promotes the beta catenin Tcf pathway which is tumor inducing and can cause cancer when expressed in particular cell populations 7 Role in embryonic development editEmbryonic development is the process where the body plan is created From studies in vertebrate model systems we can infer the roles of particular genes in human anatomical structures Wnt3a plays a role in these processes Body plan Torso edit Wnt3A patterns a multipotent stem cell population that form neurons muscles bones and cartilage of the torso region Wnt3a instructs these multipotent stems cells to form muscle bone and cartilage progenitors over forming neurons 8 Wnt3A also regulates the Notch pathway to control the segmentation clock needed for normal torso development 9 10 Left Right patterning edit Wnt3a is in a signaling pathway that activates the gene Nodal which is left side signaling determinant 11 Intestine Colon edit The colon portion of the gastrointestinal tract is completely dependent on Wnt3a and Wnt3a selectively causes the growth of colon progenitors 12 Neural crest edit Wnt3a expands neural crest cells during early development 13 Blood cells edit Wnt3a promotes hematopoietic stem cell self renewal Wnt3a is needed for myeloid but not B lymphoid development at the progenitor level and affected immature thymocyte differentiation 14 Brain Hippocampus edit Wnt3a is needed for formation of the hippocampus portion of the brain 15 Teeth edit Wnt3a promotes stem cell properties of dental pulp stem cells 16 References edit a b c GRCh38 Ensembl release 89 ENSG00000154342 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000009900 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene WNT3A wingless type MMTV integration site family member 3A Yoshikawa Y Fujimori T McMahon AP Takada S March 1997 Evidence that absence of Wnt 3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse Developmental Biology 183 2 234 42 doi 10 1006 dbio 1997 8502 PMID 9126297 Pashirzad M Fiuji H Khazei M Moradi Binabaj M Ryzhikov M Shabani M et al October 2019 Role of Wnt3a in the pathogenesis of cancer current status and prospective Molecular Biology Reports 46 5 5609 5616 doi 10 1007 s11033 019 04895 4 PMID 31236761 S2CID 195329662 Garriock RJ Chalamalasetty RB Kennedy MW Canizales LC Lewandoski M Yamaguchi TP May 2015 Lineage tracing of neuromesodermal progenitors reveals novel Wnt dependent roles in trunk progenitor cell maintenance and differentiation Development 142 9 1628 38 doi 10 1242 dev 111922 PMC 4419273 PMID 25922526 Aulehla A Wehrle C Brand Saberi B Kemler R Gossler A Kanzler B Herrmann BG March 2003 Wnt3a plays a major role in the segmentation clock controlling somitogenesis Developmental Cell 4 3 395 406 doi 10 1016 s1534 5807 03 00055 8 PMID 12636920 Nakaya MA Biris K Tsukiyama T Jaime S Rawls JA Yamaguchi TP December 2005 Wnt3a links left right determination with segmentation and anteroposterior axis elongation Development 132 24 5425 36 doi 10 1242 dev 02149 PMC 1389788 PMID 16291790 Nakaya MA Biris K Tsukiyama T Jaime S Rawls JA Yamaguchi TP December 2005 Wnt3a links left right determination with segmentation and anteroposterior axis elongation Development 132 24 5425 36 doi 10 1242 dev 02149 PMC 1389788 PMID 16291790 Garriock RJ Chalamalasetty RB Zhu J Kennedy MW Kumar A Mackem S Yamaguchi TP April 2020 A dorsal ventral gradient of Wnt3a b catenin signals controls mouse hindgut extension and colon formation Development 147 8 dev185108 doi 10 1242 dev 185108 PMC 7174843 PMID 32156757 Ikeya M Lee SM Johnson JE McMahon AP Takada S October 1997 Wnt signalling required for expansion of neural crest and CNS progenitors Nature 389 6654 966 70 Bibcode 1997Natur 389 966I doi 10 1038 40146 PMID 9353119 S2CID 4359867 Luis TC Weerkamp F Naber BA Baert MR de Haas EF Nikolic T et al January 2009 Wnt3a deficiency irreversibly impairs hematopoietic stem cell self renewal and leads to defects in progenitor cell differentiation Blood 113 3 546 54 doi 10 1182 blood 2008 06 163774 hdl 1765 19345 PMID 18832654 S2CID 1932170 Lee SM Tole S Grove E McMahon AP February 2000 A local Wnt 3a signal is required for development of the mammalian hippocampus Development 127 3 457 67 doi 10 1242 dev 127 3 457 PMID 10631167 Uribe Etxebarria V Garcia Gallastegui P Perez Garrastachu M Casado Andres M Irastorza I Unda F et al March 2020 Wnt 3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells Cells 9 3 E652 doi 10 3390 cells9030652 PMC 7140622 PMID 32156036 Further reading editSmolich BD McMahon JA McMahon AP Papkoff J December 1993 Wnt family proteins are secreted and associated with the cell surface Molecular Biology of the Cell 4 12 1267 75 doi 10 1091 mbc 4 12 1267 PMC 275763 PMID 8167409 Huguet EL McMahon JA McMahon AP Bicknell R Harris AL May 1994 Differential expression of human Wnt genes 2 3 4 and 7B in human breast cell lines and normal and disease states of human breast tissue Cancer Research 54 10 2615 21 PMID 8168088 Gazit A Yaniv A Bafico A Pramila T Igarashi M Kitajewski J Aaronson SA October 1999 Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response Oncogene 18 44 5959 66 doi 10 1038 sj onc 1202985 PMID 10557084 Tanaka K Okabayashi K Asashima M Perrimon N Kadowaki T July 2000 The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family European Journal of Biochemistry 267 13 4300 11 doi 10 1046 j 1432 1033 2000 01478 x PMID 10866835 Katoh M February 2002 Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2 MCF 7 and MKN45 International Journal of Oncology 20 2 373 7 doi 10 3892 ijo 20 2 373 PMID 11788904 Katoh M March 2002 Molecular cloning and expression of mouse Wnt14 and structural comparison between mouse Wnt14 Wnt3a gene cluster and human WNT14 WNT3A gene cluster International Journal of Molecular Medicine 9 3 221 7 doi 10 3892 ijmm 9 3 221 PMID 11836627 Filali M Cheng N Abbott D Leontiev V Engelhardt JF September 2002 Wnt 3A beta catenin signaling induces transcription from the LEF 1 promoter The Journal of Biological Chemistry 277 36 33398 410 doi 10 1074 jbc M107977200 PMID 12052822 Hering H Sheng M June 2002 Direct interaction of Frizzled 1 2 4 and 7 with PDZ domains of PSD 95 FEBS Letters 521 1 3 185 9 doi 10 1016 S0014 5793 02 02831 4 PMID 12067714 S2CID 39243103 Strausberg RL Feingold EA Grouse LH Derge JG Klausner RD Collins FS et al December 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proceedings of the National Academy of Sciences of the United States of America 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hino S Michiue T Asashima M Kikuchi A April 2003 Casein kinase I epsilon enhances the binding of Dvl 1 to Frat 1 and is essential for Wnt 3a induced accumulation of beta catenin The Journal of Biological Chemistry 278 16 14066 73 doi 10 1074 jbc M213265200 PMID 12556519 Qiang YW Endo Y Rubin JS Rudikoff S March 2003 Wnt signaling in B cell neoplasia Oncogene 22 10 1536 45 doi 10 1038 sj onc 1206239 PMID 12629517 Hocevar BA Mou F Rennolds JL Morris SM Cooper JA Howe PH June 2003 Regulation of the Wnt signaling pathway by disabled 2 Dab2 The EMBO Journal 22 12 3084 94 doi 10 1093 emboj cdg286 PMC 162138 PMID 12805222 Liu G Bafico A Harris VK Aaronson SA August 2003 A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor Molecular and Cellular Biology 23 16 5825 35 doi 10 1128 MCB 23 16 5825 5835 2003 PMC 166321 PMID 12897152 Swiatek W Tsai IC Klimowski L Pepler A Barnette J Yost HJ Virshup DM March 2004 Regulation of casein kinase I epsilon activity by Wnt signaling The Journal of Biological Chemistry 279 13 13011 7 doi 10 1074 jbc M304682200 PMID 14722104 Zilberberg A Yaniv A Gazit A April 2004 The low density lipoprotein receptor 1 LRP1 interacts with the human frizzled 1 HFz1 and down regulates the canonical Wnt signaling pathway The Journal of Biological Chemistry 279 17 17535 42 doi 10 1074 jbc M311292200 PMID 14739301 Lu W Yamamoto V Ortega B Baltimore D October 2004 Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth Cell 119 1 97 108 doi 10 1016 j cell 2004 09 019 PMID 15454084 S2CID 18567677 Capurro MI Shi W Sandal S Filmus J December 2005 Processing by convertases is not required for glypican 3 induced stimulation of hepatocellular carcinoma growth The Journal of Biological Chemistry 280 50 41201 6 doi 10 1074 jbc M507004200 PMID 16227623 Thrasivoulou C Millar M Ahmed A December 2013 Activation of intracellular calcium by multiple Wnt ligands and translocation of b catenin into the nucleus a convergent model of Wnt Ca2 and Wnt b catenin pathways The Journal of Biological Chemistry 288 50 35651 9 doi 10 1074 jbc M112 437913 PMC 3861617 PMID 24158438 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title WNT3A amp oldid 1193884594, wikipedia, wiki, book, books, library,
