Fluocinonide

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Fluocinonide (sold under various brand names) is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis.^[2] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.^[2]

Fluocinonide

Clinical data
Trade names	Fluonex, Lidex, others^[1]
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601054
Routes of administration	Topical
ATC code	C05AA11 (WHO) D07AC08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Metabolism	hepatic
Identifiers
IUPAC name 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
CAS Number	356-12-7^Y
PubChem CID	9642
IUPHAR/BPS	7078
DrugBank	DB01047^Y
ChemSpider	9265^Y
UNII	2W4A77YPAN
KEGG	D00325^Y
ChEMBL	ChEMBL1501^Y
CompTox Dashboard (EPA)	DTXSID8045307
ECHA InfoCard	100.005.998
Chemical and physical data
Formula	C26H32F2O7
Molar mass	494.532 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C
InChI InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1^Y Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N^Y
(verify)

A common potential adverse effect is skin atrophy (thinning of the skin).^[3] Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (HPA) suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria.^{[medical citation needed]}

In 2020, it was the 280th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[4][5]

Veterinary uses

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.^[6] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.^[7]

References

1. MedlinePlus Drug Information: Fluocinonide Topical
2. "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 2022-11-16.
3. Jablonska, S.; Groniowska, M.; Dabroswki, J. (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. ISSN 0007-0963. PMID 154921. S2CID 30656827.
4. "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
5. "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
6. Dog Allergies www.squidoo.com/dogallergy
7. Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". Journal of the American Veterinary Medical Association. 191 (6): 685–8. PMID 2824410.

External links

• "Fluocinonide". Drug Information Portal. U.S. National Library of Medicine.