The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[6][8] In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000128218 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000903 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rosnet O, Mattei MG, Delattre O, Schiff C (Apr 2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse". Cytogenet Cell Genet. 87 (3–4): 205–8. doi:10.1159/000015468. PMID 10702669. S2CID 5914943.
^ abcFelizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H (2015). "Pre-B lymphocyte protein 3 (VPREB3) expression in the adrenal cortex: precedent for non-immunological roles in normal and neoplastic human tissues". Endocrine Pathology. [in press].
^Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C (Mar 2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem. 279 (11): 10228–36. doi:10.1074/jbc.M312169-A200. PMID 14670953.
Melchers F, Karasuyama H, Haasner D, et al. (1993). "The surrogate light chain in B-cell development". Immunol. Today. 14 (2): 60–8. doi:10.1016/0167-5699(93)90060-X. PMID 8166770.
Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. doi:10.1016/S0021-9258(18)46934-7. PMID 7961773.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rangel R, McKeller MR, Sims-Mourtada JC, et al. (2005). "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript". J. Biol. Chem. 280 (18): 17807–14. doi:10.1074/jbc.M409479200. PMID 15757909.
This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.
vpreb3, lymphocyte, protein, protein, that, humans, encoded, gene, identifiersaliases, 8hs20, n27c7, lymphocyte, cell, surrogate, light, chain, 3external, idsomim, 605017, 98938, homologene, 7598, genecards, orthologsgene, location, human, chromosome, human, b. Pre B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene 5 6 7 8 VPREB3IdentifiersAliasesVPREB3 8HS20 N27C7 2 pre B lymphocyte 3 V set pre B cell surrogate light chain 3External IDsOMIM 605017 MGI 98938 HomoloGene 7598 GeneCards VPREB3 OMA VPREB3 orthologsGene location Human Chr Chromosome 22 human 1 Band22q11 23 22q11Start23 752 743 bp 1 End23 754 425 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 C1Start75 778 891 bp 2 End75 785 491 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodespleenappendixbone marrowbone marrow cellsbloodright adrenal glandthymusleft adrenal glandrectumTop expressed inmorulaspleenbloodspermatocyteright lungbone marrowright lung lobethymusolfactory epitheliumsecondary oocyteMore reference expression dataBioGPSMore reference expression dataOrthologsSpeciesHumanMouseEntrez2980222364EnsemblENSG00000128218ENSMUSG00000000903UniProtQ9UKI3n aRefSeq mRNA NM 013378NM 009514NM 001358532RefSeq protein NP 037510n aLocation UCSC Chr 22 23 75 23 75 MbChr 10 75 78 75 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The VPREB3 gene product is the human homologue of the mouse VpreB3 8HS20 protein and is specifically expressed in cell lines representative of all stages of B lymphocyte differentiation It is also related to VPREB1 and other members of the immunoglobulin supergene family The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre B cell receptor biosynthesis The precise function of VPREB3 is not known but it may contribute to mu chain transport in pre B cells 6 8 In humans besides the bone marrow and secondary lymphoid tissues such as the tonsils the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000128218 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000000903 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rosnet O Mattei MG Delattre O Schiff C Apr 2000 VPREB3 cDNA characterization and expression in human and chromosome mapping in human and mouse Cytogenet Cell Genet 87 3 4 205 8 doi 10 1159 000015468 PMID 10702669 S2CID 5914943 a b c Felizola SJ Katsu K Ise K Nakamura Y Arai Y Satoh F Sasano H 2015 Pre B lymphocyte protein 3 VPREB3 expression in the adrenal cortex precedent for non immunological roles in normal and neoplastic human tissues Endocrine Pathology in press Rosnet O Blanco Betancourt C Grivel K Richter K Schiff C Mar 2004 Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells J Biol Chem 279 11 10228 36 doi 10 1074 jbc M312169 A200 PMID 14670953 a b Entrez Gene VPREB3 pre B lymphocyte gene 3 Further reading editMelchers F Karasuyama H Haasner D et al 1993 The surrogate light chain in B cell development Immunol Today 14 2 60 8 doi 10 1016 0167 5699 93 90060 X PMID 8166770 Ohnishi K Takemori T 1994 Molecular components and assembly of mu surrogate light chain complexes in pre B cell lines J Biol Chem 269 45 28347 53 doi 10 1016 S0021 9258 18 46934 7 PMID 7961773 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Clark HF Gurney AL Abaya E et al 2003 The secreted protein discovery initiative SPDI a large scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Collins JE Wright CL Edwards CA et al 2005 A genome annotation driven approach to cloning the human ORFeome Genome Biol 5 10 R84 doi 10 1186 gb 2004 5 10 r84 PMC 545604 PMID 15461802 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rangel R McKeller MR Sims Mourtada JC et al 2005 Assembly of the kappa preB receptor requires a V kappa like protein encoded by a germline transcript J Biol Chem 280 18 17807 14 doi 10 1074 jbc M409479200 PMID 15757909 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title VPREB3 amp oldid 1187035219, wikipedia, wiki, book, books, library,
