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UNC93A

March 14, 2024

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[5]

UNC93A
Identifiers
AliasesUNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDsOMIM: 607995 MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Orthologs
SpeciesHumanMouse
Entrez

54346

381058

Ensembl

ENSG00000112494

ENSMUSG00000067049

UniProt

Q86WB7

Q710D3

RefSeq (mRNA)

NM_001143947
NM_018974

NM_199252

RefSeq (protein)

NP_001137419
NP_061847

NP_954860

Location (UCSC)Chr 6: 167.27 – 167.32 MbChr 17: 13.33 – 13.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[6][7] It belongs to the atypical SLCs that was recently listed.[6] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.[8][9]

UNC93A is affected by amino acid deprivation in cell cortex cultures[7][8] and starvation in in vivo samples.[8]

It is expressed in neurons, with staining close to the plasma membrane.[8]

Read also [10][11] for functional studies in C.elegans.


For you who are interested to read more about Unc93A in different species, see: [12]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
  6. ^ a b Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. ^ a b Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  8. ^ a b c d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
  9. ^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  10. ^ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
  11. ^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
  12. ^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.

Further reading edit

  • Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.


 

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

March 14, 2024
unc93a, homolog, elegans, protein, that, humans, encoded, gene, identifiersaliases, dj366n23, dj366n23, gene, homolog, elegans, homolog, aexternal, idsomim, 607995, 1933250, homologene, 10356, genecards, gene, location, human, chromosome, human, band6q27start1. Unc 93 homolog A C elegans is a protein that in humans is encoded by the UNC93A gene 5 UNC93AIdentifiersAliasesUNC93A Unc 93A dJ366N23 1 dJ366N23 2 UNC93A gene unc 93 homolog A C elegans unc 93 homolog AExternal IDsOMIM 607995 MGI 1933250 HomoloGene 10356 GeneCards UNC93AGene location Human Chr Chromosome 6 human 1 Band6q27Start167 271 169 bp 1 End167 316 014 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 A1 17 8 78 cMStart13 327 504 bp 2 End13 350 697 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocyteskin of abdomenright lobe of liverduodenumrectumgallbladderkidneymetanephrosthymusvaginaTop expressed intesticleblastocystjejunumspermatidesophagusduodenumplacentawhite adipose tissuecolonileumMore reference expression dataBioGPSn aGene ontologyMolecular functionmolecular functionCellular componentmembrane integral component of membrane plasma membraneBiological processbiological processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez54346381058EnsemblENSG00000112494ENSMUSG00000067049UniProtQ86WB7Q710D3RefSeq mRNA NM 001143947NM 018974NM 199252RefSeq protein NP 001137419NP 061847NP 954860Location UCSC Chr 6 167 27 167 32 MbChr 17 13 33 13 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseUnc93A is a major facilitator superfamily MFS and a putative solute carrier in humans 6 7 It belongs to the atypical SLCs that was recently listed 6 It is therefore presumed that UNC93A is a transporter protein UNC93A is closely related to UNC93B1 and MFSD11 8 9 UNC93A is affected by amino acid deprivation in cell cortex cultures 7 8 and starvation in in vivo samples 8 It is expressed in neurons with staining close to the plasma membrane 8 Read also 10 11 for functional studies in C elegans For you who are interested to read more about Unc93A in different species see 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000112494 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000067049 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Unc 93 homolog A C elegans a b Perland E Fredriksson R March 2017 Classification Systems of Secondary Active Transporters Trends in Pharmacological Sciences 38 3 305 315 doi 10 1016 j tips 2016 11 008 PMID 27939446 a b Perland E Bagchi S Klaesson A Fredriksson R September 2017 Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type evolutionary conservation predicted structure and neuronal co expression Open Biology 7 9 170142 doi 10 1098 rsob 170142 PMC 5627054 PMID 28878041 a b c d Ceder MM Lekholm E Hellsten SV Perland E Fredriksson R 2017 The Neuronal and Peripheral Expressed Membrane Bound UNC93A Respond to Nutrient Availability in Mice Frontiers in Molecular Neuroscience 10 351 doi 10 3389 fnmol 2017 00351 PMC 5671512 PMID 29163028 Perland E Lekholm E Eriksson MM Bagchi S Arapi V Fredriksson R 2016 The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis PLOS ONE 11 6 e0156912 Bibcode 2016PLoSO 1156912P doi 10 1371 journal pone 0156912 PMC 4896477 PMID 27272503 Levin JZ Horvitz HR April 1992 The Caenorhabditis elegans unc 93 gene encodes a putative transmembrane protein that regulates muscle contraction The Journal of Cell Biology 117 1 143 55 doi 10 1083 jcb 117 1 143 PMC 2289394 PMID 1313436 de la Cruz IP Levin JZ Cummins C Anderson P Horvitz HR October 2003 sup 9 sup 10 and unc 93 may encode components of a two pore K channel that coordinates muscle contraction in Caenorhabditis elegans The Journal of Neuroscience 23 27 9133 45 doi 10 1523 JNEUROSCI 23 27 09133 2003 PMC 6740817 PMID 14534247 Ceder Mikaela M Aggarwal Tanya Hosseini Kimia Maturi Varun Patil Sourabh Perland Emelie Williams Michael J Fredriksson Robert 2020 CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells A First In Depth Characterization of the Putative Solute Carrier UNC93A Frontiers in Cell and Developmental Biology 8 580291 doi 10 3389 fcell 2020 580291 ISSN 2296 634X PMC 7591606 PMID 33163493 Further reading editLiu Y Dodds P Emilion G Mungall AJ Dunham I Beck S Wells RS Charnock FM Ganesan TS October 2002 The human homologue of unc 93 maps to chromosome 6q27 characterisation and analysis in sporadic epithelial ovarian cancer BMC Genetics 3 20 doi 10 1186 1471 2156 3 20 PMC 134458 PMID 12381271 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title UNC93A amp oldid 1187380843, wikipedia, wiki, book, books, library,

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