This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000110057 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036908 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, Klein G, Zabarovsky ER (January 2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–17. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.
Further readingedit
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kashuba VI, Protopopov AI, Kvasha SM, et al. (2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–17. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Arnlöv J, Sundström J, Lind L, et al. (2006). "hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men". Eur. J. Heart Fail. 7 (6): 958–65. doi:10.1016/j.ejheart.2004.06.009. PMID 16111919. S2CID 22339419.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
Casrouge A, Zhang SY, Eidenschenk C, et al. (2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–12. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. PMID 16973841. S2CID 12501759.
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unc93b1, homolog, elegans, also, known, protein, which, humans, encoded, gene, identifiersaliases, iiae1, unc93, unc93b, 93b1, homolog, elegans, homolog, signaling, regulatorexternal, idsomim, 608204, 1859307, homologene, 41325, genecards, gene, location, huma. Unc 93 homolog B1 C elegans also known as UNC93B1 is a protein which in humans is encoded by the UNC93B1 gene 5 6 UNC93B1IdentifiersAliasesUNC93B1 IIAE1 UNC93 UNC93B Unc 93B1 unc 93 homolog B1 C elegans unc 93 homolog B1 TLR signaling regulatorExternal IDsOMIM 608204 MGI 1859307 HomoloGene 41325 GeneCards UNC93B1Gene location Human Chr Chromosome 11 human 1 Band11q13 2Start67 991 100 bp 1 End68 004 982 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 19 AStart3 985 186 bp 2 End3 999 340 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytespleenbone marrow cellsappendixright lungright uterine tubeupper lobe of left lungminor salivary glandsgallbladderstromal cell of endometriumTop expressed inspleencalvariaankle jointanklesubmandibular glandsubcutaneous adipose tissuelipduodenumthymuswhite adipose tissueMore reference expression dataBioGPSn aGene ontologyMolecular functionToll like receptor bindingCellular componentintegral component of membrane early phagosome Golgi membrane endosome lysosome phagocytic vesicle endoplasmic reticulum membrane endoplasmic reticulum membrane cytoplasmic vesicleBiological processtoll like receptor 9 signaling pathway intracellular protein transport toll like receptor 3 signaling pathway adaptive immune response defense response to virus toll like receptor 7 signaling pathway toll like receptor signaling pathway immune system process innate immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8162254445EnsemblENSG00000110057ENSMUSG00000036908UniProtQ9H1C4Q8VCW4RefSeq mRNA NM 030930NM 001161428NM 019449RefSeq protein NP 112192NP 001154900NP 062322Location UCSC Chr 11 67 99 68 MbChr 19 3 99 4 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThis gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000110057 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036908 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene UNC93B1 unc 93 homolog B1 C elegans Kashuba VI Protopopov AI Kvasha SM Gizatullin RZ Wahlestedt C Kisselev LL Klein G Zabarovsky ER January 2002 hUNC93B1 a novel human gene representing a new gene family and encoding an unc 93 like protein Gene 283 1 2 209 17 doi 10 1016 S0378 1119 01 00856 3 PMID 11867227 Further reading editAndersson B Wentland MA Ricafrente JY et al 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Yu W Andersson B Worley KC et al 1997 Large Scale Concatenation cDNA Sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Sanger Centre The Washington University Genome Sequencing Cente The 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Kashuba VI Protopopov AI Kvasha SM et al 2002 hUNC93B1 a novel human gene representing a new gene family and encoding an unc 93 like protein Gene 283 1 2 209 17 doi 10 1016 S0378 1119 01 00856 3 PMID 11867227 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Arnlov J Sundstrom J Lind L et al 2006 hUNC 93B1 a novel gene mainly expressed in the heart is related to left ventricular diastolic function heart failure morbidity and mortality in elderly men Eur J Heart Fail 7 6 958 65 doi 10 1016 j ejheart 2004 06 009 PMID 16111919 S2CID 22339419 Taylor TD Noguchi H Totoki Y et al 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification Nature 440 7083 497 500 Bibcode 2006Natur 440 497T doi 10 1038 nature04632 PMID 16554811 Casrouge A Zhang SY Eidenschenk C et al 2006 Herpes simplex virus encephalitis in human UNC 93B deficiency Science 314 5797 308 12 Bibcode 2006Sci 314 308C doi 10 1126 science 1128346 PMID 16973841 S2CID 12501759 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title UNC93B1 amp oldid 1213959937, wikipedia, wiki, book, books, library,
