Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses. TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence.[2]
Structureedit
The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:[1]
^ abReymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC125245. PMID 11331580.
^Ozato K, Shin DM, Chang TH, Morse HC (November 2008). "TRIM family proteins and their emerging roles in innate immunity". Nat. Rev. Immunol. 8 (11): 849–60. doi:10.1038/nri2413. PMC3433745. PMID 18836477.
^Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G (2008). "Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties". BMC Evol. Biol. 8 (1): 225. Bibcode:2008BMCEE...8..225S. doi:10.1186/1471-2148-8-225. PMC2533329. PMID 18673550.
tripartite, motif, family, tripartite, motif, family, trim, protein, family, contents, function, structure, family, members, referencesfunction, editmany, trim, proteins, induced, interferons, which, important, component, resistance, pathogens, several, trim, . The tripartite motif family TRIM is a protein family 1 Contents 1 Function 2 Structure 3 Family members 4 ReferencesFunction editMany TRIM proteins are induced by interferons which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses TRIM proteins are involved in pathogen recognition and by regulation of transcriptional pathways in host defence 2 nbsp Structure editThe tripartite motif is always present at the N terminus of the TRIM proteins The TRIM motif includes the following three domains 1 1 a RING finger domain 2 one or two B box zinc finger domains when only one B box is present it is always a type 2 B box when two B boxes are present the type 1 B Box always precedes the type 2 B Box 3 coiled coil regionThe C terminus of TRIM proteins contain either Group 1 proteins a C terminal domain selected from the following list NHL and IGFLMN domains either in association or alone PHD domain associated with a bromodomain MATH domain in e g TRIM37 ARF domain in e g TRIM23 EXOIII domain in e g TRIM19 or Group 2 proteins a SPRY C terminal domain e g TRIM21Family members editThe TRIM family is split into two groups that differ in domain structure and genomic organization 3 Group 1 members possess a variety of C terminal domains and are represented in both vertebrate and invertebrates Group 2 is absent in invertebrates possess a C terminal SPRY domain 4 Members of the family include Group 1 PHD BROMO domain containing TRIM24 TIF1a TRIM28 TIF1b TRIM33 TIF1g act as corepressors 1 10 TRIM1 TRIM2 TRIM3 TRIM8 TRIM9 11 20 TRIM12 TRIM13 TRIM14 TRIM16 TRIM18 TRIM19 21 30 TRIM23 TRIM25 TRIM29 TRIM30 31 40 TRIM32 TRIM36 TRIM37 41 50 TRIM42 TRIM44 TRIM45 TRIM46 TRIM47 51 60 TRIM51 TRIM53 TRIM54 TRIM55 TRIM56 TRIM57 TRIM59 61 70 TRIM62 TRIM63 TRIM65 TRIM66 TRIM67 TRIM69 TRIM70 71 75 TRIM71 Group 2 1 10 TRIM4 TRIM5 TRIM6 TRIM7 TRIM10 11 20 TRIM11 TRIM12 TRIM15 TRIM17 TRIM20 21 30 TRIM21 TRIM22 TRIM26 TRIM27 TRIM30 31 40 TRIM31 TRIM34 TRIM35 TRIM38 TRIM39 TRIM40 41 50 TRIM41 TRIM43 TRIM48 TRIM49 TRIM50 51 60 TRIM51 TRIM52 TRIM53 TRIM57 TRIM58 TRIM60 61 70 TRIM61 TRIM64 TRIM68 TRIM69 TRIM70 71 75 TRIM72 TRIM73 TRIM74 TRIM75References edit a b Reymond A Meroni G Fantozzi A Merla G Cairo S Luzi L Riganelli D Zanaria E Messali S Cainarca S Guffanti A Minucci S Pelicci PG Ballabio A May 2001 The tripartite motif family identifies cell compartments EMBO J 20 9 2140 51 doi 10 1093 emboj 20 9 2140 PMC 125245 PMID 11331580 Ozato K Shin DM Chang TH Morse HC November 2008 TRIM family proteins and their emerging roles in innate immunity Nat Rev Immunol 8 11 849 60 doi 10 1038 nri2413 PMC 3433745 PMID 18836477 Sardiello M Cairo S Fontanella B Ballabio A Meroni G 2008 Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties BMC Evol Biol 8 1 225 Bibcode 2008BMCEE 8 225S doi 10 1186 1471 2148 8 225 PMC 2533329 PMID 18673550 Ponting C Schultz J Bork P June 1997 SPRY domains in ryanodine receptors Ca 2 release channels Trends Biochem Sci 22 6 193 4 doi 10 1016 S0968 0004 97 01049 9 PMID 9204703 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Tripartite motif family amp oldid 1187728265, wikipedia, wiki, book, books, library,
