The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[8]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000050747 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC125245. PMID 11331580.
^Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet. 54 (2): 244–51. PMC1918154. PMID 8304341.
^Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC1526686. PMID 16702430.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells". Mol. Cell. Biol. 19 (5): 3808–15. doi:10.1128/MCB.19.5.3808. PMC84222. PMID 10207104.
April 12, 2024
trim15, tripartite, motif, containing, protein, protein, that, humans, encoded, gene, identifiersaliases, rnf93, znf178, znfb7, tripartite, motif, containing, 15external, idsmgi, 1916347, homologene, 23819, genecards, gene, location, human, chromosome, human, . Tripartite motif containing protein 15 is a protein that in humans is encoded by the TRIM15 gene 5 6 7 8 TRIM15IdentifiersAliasesTRIM15 RNF93 ZNF178 ZNFB7 tripartite motif containing 15External IDsMGI 1916347 HomoloGene 23819 GeneCards TRIM15Gene location Human Chr Chromosome 6 human 1 Band6p22 1Start30 163 206 bp 1 End30 172 693 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 B1Start37 171 583 bp 2 End37 178 102 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed induodenumrectumright lobe of livergallbladderkidneyappendixsmooth muscle tissueislet of Langerhansrenal cortexbone marrowTop expressed inintestinal villusileumjejunumduodenumsecondary oocyteyolk sacPaneth cellmucous cell of stomachsupraoptic nucleusproximal tubuleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionzinc ion binding protein binding metal ion bindingCellular componentintracellular anatomical structureBiological processmesodermal cell fate determination positive regulation of DNA binding transcription factor activity innate immune response positive regulation of RIG I signaling pathway positive regulation of NF kappaB transcription factor activity positive regulation of type I interferon production negative regulation of intracellular transport of viral materialSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8987069097EnsemblENSG00000235960ENSG00000227147ENSG00000233599ENSG00000204610ENSG00000224145ENSG00000235905ENSG00000137384ENSG00000235259ENSMUSG00000050747UniProtQ9C019n aRefSeq mRNA NM 033229NM 052812NM 001024134NM 001177872RefSeq protein NP 150232n aLocation UCSC Chr 6 30 16 30 17 MbChr 17 37 17 37 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a member of the tripartite motif TRIM family The TRIM motif includes three zinc binding domains a RING a B box type 1 and a B box type 2 and a coiled coil region The protein localizes to the cytoplasm Its function has not been identified Alternate splicing of this gene results in two transcript variants encoding different isoforms 8 References edit a b c ENSG00000227147 ENSG00000233599 ENSG00000204610 ENSG00000224145 ENSG00000235905 ENSG00000137384 ENSG00000235259 GRCh38 Ensembl release 89 ENSG00000235960 ENSG00000227147 ENSG00000233599 ENSG00000204610 ENSG00000224145 ENSG00000235905 ENSG00000137384 ENSG00000235259 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000050747 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Reymond A Meroni G Fantozzi A Merla G Cairo S Luzi L Riganelli D Zanaria E Messali S Cainarca S Guffanti A Minucci S Pelicci PG Ballabio A May 2001 The tripartite motif family identifies cell compartments EMBO J 20 9 2140 51 doi 10 1093 emboj 20 9 2140 PMC 125245 PMID 11331580 Goei VL Parimoo S Capossela A Chu TW Gruen JR Mar 1994 Isolation of novel non HLA gene fragments from the hemochromatosis region 6p21 3 by cDNA hybridization selection Am J Hum Genet 54 2 244 51 PMC 1918154 PMID 8304341 Gruen JR Nalabolu SR Chu TW Bowlus C Fan WF Goei VL Wei H Sivakamasundari R Liu Y Xu HX Parimoo S Nallur G Ajioka R Shukla H Bray Ward P Pan J Weissman SM Feb 1997 A transcription map of the major histocompatibility complex MHC class I region Genomics 36 1 70 85 doi 10 1006 geno 1996 0427 PMID 8812418 a b Entrez Gene TRIM15 tripartite motif containing 15 Further reading editShiina T Ota M Shimizu S et al 2006 Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity Genetics 173 3 1555 70 doi 10 1534 genetics 106 057034 PMC 1526686 PMID 16702430 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Suzuki Y Yamashita R Shirota M et al 2004 Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions Genome Res 14 9 1711 8 doi 10 1101 gr 2435604 PMC 515316 PMID 15342556 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Harada H Harada Y O Brien DP et al 1999 HERF1 a Novel Hematopoiesis Specific RING Finger Protein Is Required for Terminal Differentiation of Erythroid Cells Mol Cell Biol 19 5 3808 15 doi 10 1128 MCB 19 5 3808 PMC 84222 PMID 10207104 Retrieved from https en wikipedia org w index php title TRIM15 amp oldid 1136389477, wikipedia, wiki, book, books, library,
