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Fetal trimethadione syndrome

April 14, 2024

Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others[1]) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.[2]

Fetal trimethadione syndrome
Other namesGerman syndrome
Condition is caused by Trimethadione (and paramethadione)

Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,[3] meaning it affects less than 200,000 individuals in the United States.[4]

The fetal loss rate while using trimethadione has been reported to be as high as 87%.[5]

Presentation edit

Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.[2][6]

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Diagnosis edit

Treatment edit

Surgery may help alleviate the effects of some physical defects, but prognosis is poor, especially for those with severe cardiovascular and cognitive problems. Speech and physical therapy, as well as special education, is required for surviving children.[7]

References edit

  1. ^ Additional names include trimethadione embryopathy and trimethadione syndrome.
  2. ^ a b Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
  3. ^ Fetal trimethadione syndrome on the ORD website. Retrieved January 2007
  4. ^ NIH's Office of Rare Diseases 2009-02-06 at the Wayback Machine Retrieved January 2007
  5. ^ Teratology and Drug Use During Pregnancy Retrieved January 2007
  6. ^ The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007
  7. ^ Brown, Robert T (2014). Encyclopedia of Special Education. Wiley Online. ISBN 9780470642160.

External links edit

April 14, 2024
fetal, trimethadione, syndrome, also, known, paramethadione, syndrome, german, syndrome, tridione, syndrome, among, others, birth, defects, caused, administration, anticonvulsants, trimethadione, also, known, tridione, paramethadione, epileptic, mothers, durin. Fetal trimethadione syndrome also known as paramethadione syndrome German syndrome tridione syndrome among others 1 is a set of birth defects caused by the administration of the anticonvulsants trimethadione also known as Tridione or paramethadione to epileptic mothers during pregnancy 2 Fetal trimethadione syndromeOther namesGerman syndromeCondition is caused by Trimethadione and paramethadione Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health s Office of Rare Diseases 3 meaning it affects less than 200 000 individuals in the United States 4 The fetal loss rate while using trimethadione has been reported to be as high as 87 5 Contents 1 Presentation 2 Diagnosis 3 Treatment 4 References 5 External linksPresentation editFetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione 2 6 Cranial and facial abnormalities which include microcephaly midfacial flattening V shaped eyebrows and a short nose Cardiovascular abnormalities Absent kidney and ureter Meningocele a birth defect of the spine Omphalocele a birth defect where portions of the abdominal contents project into the umbilical cord A delay in mental and physical developmentListen to this article 2 minutes source source nbsp This audio file was created from a revision of this article dated 31 January 2007 2007 01 31 and does not reflect subsequent edits Audio help More spoken articles Diagnosis editThis section is empty You can help by adding to it July 2017 Treatment editSurgery may help alleviate the effects of some physical defects but prognosis is poor especially for those with severe cardiovascular and cognitive problems Speech and physical therapy as well as special education is required for surviving children 7 References edit Additional names include trimethadione embryopathy and trimethadione syndrome a b Multiple Congenital Anomaly Mental Retardation MCA MR Syndromes Retrieved January 2007 Fetal trimethadione syndrome on the ORD website Retrieved January 2007 NIH s Office of Rare Diseases Archived 2009 02 06 at the Wayback Machine Retrieved January 2007 Teratology and Drug Use During Pregnancy Retrieved January 2007 The fetal trimethadione syndrome report of an additional family and further delineation of this syndrome Retrieved January 2007 Brown Robert T 2014 Encyclopedia of Special Education Wiley Online ISBN 9780470642160 External links edit Retrieved from https en wikipedia org w index php title Fetal trimethadione syndrome amp oldid 1119172484, wikipedia, wiki, book, books, library,

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