The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.[6]
Geneedit
The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.[7] It is a complex locus that contains both TMEM151B and SPATS1.[8] TMEM151B has one paralog: TMEM151A.[9]
Transcriptedit
The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.[7]
Visualization of the TMEM151B gene. The green lines above the diagram show other promotors within the gene.
Proteinedit
2D visualization of the TMEM151B protein using Protter.[10]3D model of the TMEM151B protein using Alpha Fold.
The protein has a length of 566 amino acids and contains two transmembrane domains.[6] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72.[11][6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.[12]
Expressionedit
RNA expression map of TMEM151B within the mouse brain[13]
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.[14] NCBI geo profiles similarly show localization to the brain tissues.[15] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.[13]
Protein interactionsedit
The TMEM151B protein interacts with one other protein according to BioGRID.[16]
SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.[17]
Homology and evolutionedit
Evolutionary rate of TMEM151B compared to that of Fibrinogen Alpha Chain and Cytochrome C.
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.[9][18] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.[9][19]
Ortholog space for TMEM151BTable of orthologs for the TMEM151B gene, found using NCBI Blast[9]
Researchedit
Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer.[20] It was also found to be up-regulated in post-menopausal breast cancer.[21][22] A SNP found within TMEM151B is associated with the development of lean muscle.[23]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000178233 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000096847 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2021-10-04.
^ abcd"BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
^"Protter - interactive protein feature visualization". wlab.ethz.ch. Retrieved 2022-01-13.
^"TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2022-01-13.
^Liu J, Li H, Shen S, Sun L, Yuan Y, Xing C (2018). "Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer". Journal of Cancer. 9 (10): 1754–1764. doi:10.7150/jca.24569. PMC5968763. PMID 29805701.
^Carter JM, Nair AA, Davila JI, Heinzen EP, Hoskin TL, Winham SJ, et al. (2019-02-15). "Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer". Poster Session Abstracts. American Association for Cancer Research. 79 (4_Supplement). doi:10.1158/1538-7445.sabcs18-p3-08-10. S2CID 164377723.
^Qian D, Zheng Q, Wu D, Ye B, Qian Y, Zhou T, et al. (2021-05-13). "Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer". Frontiers in Oncology. 11: 670138. doi:10.3389/fonc.2021.670138. PMC8158160. PMID 34055638.
^Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, et al. (November 2019). "Two functional variants at 6p21.1 were associated with lean mass". Skeletal Muscle. 9 (1): 28. doi:10.1186/s13395-019-0212-3. PMC6874818. PMID 31757224.
Further readingedit
Tsai JY, Namin-Gonzalez ML, Silver LM (December 1994). "False association of human ESTs". Nature Genetics. 8 (4): 321–322. doi:10.1038/ng1294-321. PMID 7894479. S2CID 6963700.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
transmembrane, protein, 151b, transmembrane, protein, 151b, protein, that, humans, encoded, tmem151b, gene, tmem151bidentifiersaliasestmem151b, c6orf137, tmem193, ba444e17, transmembrane, protein, 151bexternal, idsmgi, 2685169, homologene, 19365, genecards, tm. Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene 5 TMEM151BIdentifiersAliasesTMEM151B C6orf137 TMEM193 bA444E17 5 transmembrane protein 151BExternal IDsMGI 2685169 HomoloGene 19365 GeneCards TMEM151BGene location Human Chr Chromosome 6 human 1 Band6p21 1Start44 270 450 bp 1 End44 307 506 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 B3Start45 852 878 bp 2 End45 860 603 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed infrontal polecerebellar vermisBrodmann area 10middle temporal gyrusorbitofrontal cortexBrodmann area 46superior frontal gyrusparietal lobepostcentral gyrusendothelial cellTop expressed incerebellar cortexsuperior frontal gyrusganglionic eminencebarrel cortexprefrontal cortexhippocampus propercerebellar vermismedial vestibular nucleuspontine nucleimedial geniculate nucleusMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez441151210573EnsemblENSG00000178233ENSMUSG00000096847UniProtQ8IW70Q68FE7RefSeq mRNA NM 001137560NM 001039704NM 001013749RefSeq protein NP 001131032NP 001013771Location UCSC Chr 6 44 27 44 31 MbChr 17 45 85 45 86 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Nomenclature 2 Gene 3 Transcript 4 Protein 4 1 Expression 4 2 Protein interactions 5 Homology and evolution 6 Research 7 References 8 Further readingNomenclature editThe Transmembrane protein 151B gene is also known as TMEM151B C6orf137 and bA444E17 5 6 Gene editThe gene is located on the positive strand of chromosome 6 at the location 6p21 1 from the chromosome position 44270450 to 44279444 for a total length of 8 995 base pairs 7 It is a complex locus that contains both TMEM151B and SPATS1 8 TMEM151B has one paralog TMEM151A 9 Transcript editThe mRNA contains 3 exons with a transcribed mRNA length of 4911bp and the coding region containing 1701bp 7 nbsp Visualization of the TMEM151B gene The green lines above the diagram show other promotors within the gene Protein edit nbsp 2D visualization of the TMEM151B protein using Protter 10 nbsp 3D model of the TMEM151B protein using Alpha Fold The protein has a length of 566 amino acids and contains two transmembrane domains 6 According to Compute pI Mw molecular weight of approximately 61 kDa which matches the weight listed on NCBI and a theoretical isoelectric point of 6 72 11 6 The human TMEM151B protein composition is poor in lysine and arginine lysine comprising 1 4 of the amino acids and arginine making up 0 8 of the total protein The mouse ortholog is also arginine poor 12 Expression edit nbsp RNA expression map of TMEM151B within the mouse brain 13 RNA seq gene expression profiling shows high expression in the brain and notable expression in the testes 14 NCBI geo profiles similarly show localization to the brain tissues 15 Within the mouse brain TMEM151B has high expression particularly within the cerebellum medulla and olfactory bulb according to the Allen Brain Atlas 13 Protein interactions edit The TMEM151B protein interacts with one other protein according to BioGRID 16 SREBF2 a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane activates genes involved with cholesterol biosynthesis 17 Homology and evolution edit nbsp Evolutionary rate of TMEM151B compared to that of Fibrinogen Alpha Chain and Cytochrome C The TMEM151B gene is conserved within most vertebrates and appears to be conserved within some invertebrates Its paralog TMEM151A has a 47 7 sequence identity with TMEM151B 9 18 The evolution rate is relatively slow between the rate of change in fibrinogen alpha and cytochrome c 9 19 nbsp Ortholog space for TMEM151B nbsp Table of orthologs for the TMEM151B gene found using NCBI Blast 9 Research editAlternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer 20 It was also found to be up regulated in post menopausal breast cancer 21 22 A SNP found within TMEM151B is associated with the development of lean muscle 23 References edit a b c GRCh38 Ensembl release 89 ENSG00000178233 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000096847 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Transmembrane protein 151B a b c transmembrane protein 151B Homo sapiens Protein NCBI www ncbi nlm nih gov Retrieved 2021 09 29 a b Homo sapiens transmembrane protein 151B TMEM151B mRNA NCBI www ncbi nlm nih gov Retrieved 2021 09 29 AceView Gene TMEM151BandSPATS1 a comprehensive annotation of human mouse and worm genes with mRNAs or ESTsAceView www ncbi nlm nih gov Retrieved 2021 10 04 a b c d BLAST Basic Local Alignment Search Tool blast ncbi nlm nih gov Retrieved 2022 01 13 Protter interactive protein feature visualization wlab ethz ch Retrieved 2022 01 13 ExPASy Compute pI Mw tool web expasy org Retrieved 2022 01 13 SAPS lt Sequence Statistics lt EMBL EBI www ebi ac uk Retrieved 2022 01 13 a b ISH Data Allen Brain Atlas Mouse Brain mouse brain map org Retrieved 2022 01 13 TMEM151B transmembrane protein 151B Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2022 01 13 GDS596 213678 at www ncbi nlm nih gov Retrieved 2022 01 13 TMEM151B RP11 444E17 5 Result Summary BioGRID thebiogrid org Retrieved 2022 01 13 SREBF2 Gene GeneCards SRBP2 Protein SRBP2 Antibody www genecards org Retrieved 2022 01 13 Clustal Omega lt Multiple Sequence Alignment lt EMBL EBI www ebi ac uk Retrieved 2022 01 13 TimeTree The Timescale of Life www timetree org Retrieved 2022 01 13 Liu J Li H Shen S Sun L Yuan Y Xing C 2018 Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer Journal of Cancer 9 10 1754 1764 doi 10 7150 jca 24569 PMC 5968763 PMID 29805701 Carter JM Nair AA Davila JI Heinzen EP Hoskin TL Winham SJ et al 2019 02 15 Abstract P3 08 10 A unique coding and non coding benign breast transcriptome in post menopausal ER breast cancer Poster Session Abstracts American Association for Cancer Research 79 4 Supplement doi 10 1158 1538 7445 sabcs18 p3 08 10 S2CID 164377723 Qian D Zheng Q Wu D Ye B Qian Y Zhou T et al 2021 05 13 Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer Frontiers in Oncology 11 670138 doi 10 3389 fonc 2021 670138 PMC 8158160 PMID 34055638 Pei YF Hu WZ Yang XL Wei XT Feng GJ Zhang H et al November 2019 Two functional variants at 6p21 1 were associated with lean mass Skeletal Muscle 9 1 28 doi 10 1186 s13395 019 0212 3 PMC 6874818 PMID 31757224 Further reading editTsai JY Namin Gonzalez ML Silver LM December 1994 False association of human ESTs Nature Genetics 8 4 321 322 doi 10 1038 ng1294 321 PMID 7894479 S2CID 6963700 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Transmembrane protein 151b amp oldid 1177467116, wikipedia, wiki, book, books, library,
