Theresa M. Reineke
Theresa M. Reineke (born January 1, 1972) is an American chemist and Distinguished McKnight University Professor at the University of Minnesota. She designs sustainable, environmentally friendly polymer-based delivery systems for targeted therapeutics. She is the associate editor of ACS Macro Letters.
Theresa Marie Reineke | |
|---|---|
| Born | January 1, 1972 |
| Alma mater | University of Wisconsin–Eau Claire Arizona State University University of Michigan |
| Scientific career | |
| Institutions | University of Minnesota California Institute of Technology |
| Thesis | Metal-organic porous frameworks designed from zinc(II), terbium(III), europium(III), and organic carboxylate building blocks (2000) |
| Doctoral advisor | Omar M. Yaghi |
Early life and education edit
Reineke earned her bachelor's degree at University of Wisconsin–Eau Claire.[1] She moved to Arizona State University for her graduate studies and earned a master's degree in 1998.[1][2] Reineke was a PhD student at the University of Michigan, where she was supervised by Michael O'Keeffe and Omar M. Yaghi.[1][3] She was awarded the Wirt and Mary Cornell Prize for Outstanding Graduate Research. Reineke joined the California Institute of Technology as an National Institutes of Health postdoctoral fellow in 2000.[1]
Research and career edit
Reineke joined the University of Minnesota in 2011. Her research group focus on the design, characterisation and functionalisation of macromolecular systems.[4][5] These macromolecules include biocompatible polymers that can deliver DNA for regenerative medicine as well as targeted therapeutic treatments.[4] She was made a Lloyd H. Reyerson Professor with tenure at the University of Minnesota in 2011.[1] Reineke has published over 140 papers.[6]
Nucleic acids can have an unparalleled specificity for targets inside a cell, but need to be compacted into nanostructures (polyplexes) that can enter cells.[7] Reineke designs polymer-based transportation systems for nucleic acids.[7] These polymer vehicles can improve the solubility and bioavailability of drugs.[8] These often incorporate carbohydrates, which have an affinity for polyplexes and are non-toxic.[7] She is a member of the University of Minnesota Centre for Sustainable Polymers, synthesising polymers from sustainable ingredients. The carbohydrate units within her polymer drug delivery systems are a widely available, renewable resource.[9] The sustainable polymers designed by Reineke include poly(ester-thioethers).[9]
Reineke used reversible addition−fragmentation chain-transfer polymerization for the synthesis of diblock terpolymers that can be used for targeted drug delivery.[10] She used spray dried dispersions of the polymer with the drug probucol.[11]
Reineke was made a University of Minnesota Distinguished McKnight University Professor in 2017.[1] She is the associate editor of ACS Macro Letters and on the Advisory Board of Biomacromolecules, Bioconjugate Chemistry and Polymer Chemistry.[1] She is a member of the American Chemical Society Polymer Division.[12] Her work has been supported by an National Science Foundation CAREER Award, a Sloan Research Fellowship, the National Institutes of Health and the National Academy of Sciences.[13]
Awards and honors edit
- 2000 Outstanding Graduate Research Award from the Wirt and Mary Cornell Prize[1]
- 2003 American Chemical Society (PMSE Division), Arthur K. Doolittle Award[14]
- 2007 YWCA Rising Star[1]
- 2007 OH Bioscience Thirty in Their 30s Award[1]
- 2012 American Society of Gene and Cell Therapy Outstanding New Investigator Award[15]
- 2012 American Chemical Society, Polymer Materials: Science and Engineering Division Macro 2012 Lecture Award[16]
- 2016 American Institute for Medical and Biological Engineering Fellow[17]
- 2016 University of Minnesota Sara Evans Faculty Woman Scholar/Leader Award[18]
- 2016 University of Minnesota George W. Taylor Award for Distinguished Research[19]
- 2017 American Chemical Society Polymer Chemistry Division Carl S. Marvel Creative Polymer Chemistry Award[20]
- 2018 Danisco Foundation DuPont Nutrition and Health Science Excellence Medal[21][22]
- 2018 American Chemical Society POLY Fellow Award[23]
- 2018 Big 10 Alliance Academic Leadership Program Fellow[24]
Patents edit
External links edit
- The Reineke Research Group
References edit
- ^ a b c d e f g h i j "Dr. Theresa M. Reineke". The Reineke Group. Retrieved 2019-04-17.
- ^ "Nonviral Synthetic Polymers Promote Cellular and In Vivo Delivery of Therapeutic Genes and Editing Systems". Breakthrough Symposium. Retrieved 2019-04-17.
- ^ "Chemistry Tree – Theresa M. Reineke". academictree.org. Retrieved 2019-04-17.
- ^ a b "Research". The Reineke Group. Retrieved 2019-04-17.
- ^ Aldevron (2018-12-04), Theresa Reineke; Breakthrough Symposium Presenter, retrieved 2019-04-17
- ^ "Publications Archive - Page 2 of 2 - The Reineke Group". Retrieved 2023-10-13.
- ^ a b c "Nucleic Acid Delivery". The Reineke Group. Retrieved 2019-04-17.
- ^ Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark. "2019 Winter Talk (Theresa M. Reineke, University of Minnesota) | Stanford Polymer Collective". web.stanford.edu. Retrieved 2019-04-17.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ a b "Sustainable Polymers". The Reineke Group. Retrieved 2019-04-17.
- ^ "Oral Drug Delivery". The Reineke Group. Retrieved 2019-04-17.
- ^ Tale, Swapnil; Purchel, Anatolii A.; Dalsin, Molly C.; Reineke, Theresa M. (2017-09-22). "Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility for Oral Administration". Molecular Pharmaceutics. 14 (11): 4121–4127. doi:10.1021/acs.molpharmaceut.7b00458. ISSN 1543-8384. PMID 28937226.
- ^ "Reineke – address". old.polyacs.org. Retrieved 2019-04-17.
- ^ "Fellows Database | Alfred P. Sloan Foundation". sloan.org. Retrieved 2022-03-24.
- ^ "Faculty Awards". www.artsci.uc.edu. Retrieved 2019-04-17.
- ^ "Outstanding New Investigator Awards | ASGCT – American Society of Gene & Cell Therapy | ASGCT – American Society of Gene & Cell Therapy". www.asgct.org. Retrieved 2019-04-17.
- ^ "MP's Reineke receives Macro 2012 Lecture Award | IPRIME". iprime.umn.edu. Retrieved 2019-04-17.
- ^ "Theresa M. Reineke, Ph.D. COF-2038 – AIMBE". Retrieved 2019-04-17.
- ^ "Reineke selected 2016 Sara Evans Faculty Woman Scholar | Center for Sustainable Polymers". Retrieved 2019-04-17.
- ^ "Theresa Reinke, of IPrime's polymer group, receives Talyor Award for Distinguished Research | IPRIME". www.iprime.umn.edu. Retrieved 2019-04-17.
- ^ "Carl S. Marvel Award for Creative Polymer Chemistry". Division of Polymer Chemistry, Inc. 2017-11-28. Retrieved 2019-04-17.
- ^ "DuPont Nutrition & Health Honors 2018 Science Excellence and Microbiome Science Award Medalists – DuPont | Danisco". www.dupontnutritionandhealth.com. Retrieved 2019-04-17.
- ^ harva015 (2018-10-11). "Reineke honored with DuPont Nutrition & Health Science Excellence Medal". Department of Chemistry. Retrieved 2019-04-17.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ harva015 (2018-02-22). "Professor Reineke named a 2018 POLY Fellow". Department of Chemistry. Retrieved 2019-04-17.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ "News | MRSEC". mrsec.umn.edu. Retrieved 2019-04-17.
- ^ "US Patent for Monomers, polymers and articles containing the same from sugar derived compounds Patent (Patent # 9,505,778 issued November 29, 2016) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.
- ^ "US Patent for Isosorbide-based polymethacrylates Patent (Patent # 9,988,393 issued June 5, 2018) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.