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Wikipedia

Thromboxane B2

Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.

Thromboxane B2
Names
Preferred IUPAC name
(5Z)-7-{(2R,3S,4S,6Ξ)-4,6-Dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-2-yl}hept-5-enoic acid
Identifiers
  • 54397-85-2 Y
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:28728 N
ECHA InfoCard 100.165.003
MeSH Thromboxane+B2
  • 5283137
UNII
  • V94M3R26ZV Y
  • DTXSID60903947
  • CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Properties
C20H34O6
Molar mass 370.48 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). [1]

2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.[2]

References edit

  1. ^ "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02.
  2. ^ Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Anna Petroni, Milena Blasevich, Marco Salami, Nadia Papini, Gian F. Montedoro and Claudio Gallia, Thrombosis Research, 15 April 1995, Volume 78, Issue 2, Pages 151–160, doi:10.1016/0049-3848(95)00043-7

thromboxane, txb2, inactive, metabolite, product, thromboxane, almost, completely, cleared, urine, namespreferred, iupac, name, dihydroxy, hydroxyoct, oxan, hept, enoic, acididentifierscas, number, 54397, model, jsmol, interactive, imagechebi, chebi, 28728, ne. Thromboxane B2 TXB2 is an inactive metabolite product of thromboxane A2 It is almost completely cleared in the urine Thromboxane B2 NamesPreferred IUPAC name 5Z 7 2R 3S 4S 63 4 6 Dihydroxy 2 1E 3S 3 hydroxyoct 1 en 1 yl oxan 2 yl hept 5 enoic acidIdentifiersCAS Number 54397 85 2 Y3D model JSmol Interactive imageChEBI CHEBI 28728 NECHA InfoCard 100 165 003MeSH Thromboxane B2PubChem CID 5283137UNII V94M3R26ZV YCompTox Dashboard EPA DTXSID60903947SMILES CCCCC C H O C C C H 1OC O C C H O C H 1C C C CCCC O OPropertiesChemical formula C20H34O6Molar mass 370 48 g molExcept where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references It itself is not involved in platelet activation and aggregation in case of a wound but its precursor thromboxane A2 is Thromboxane A2 synthesis is the target of the drug aspirin which inhibits the COX 1 enzyme the source of thromboxane A2 in platelets 1 2 3 4 Di hydroxyphenyl ethanol DHPE is a phenolic component of extra virgin olive oil An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro 2 References edit Definition thromboxane b2 from Online Medical Dictionary Retrieved 2008 11 02 Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil Anna Petroni Milena Blasevich Marco Salami Nadia Papini Gian F Montedoro and Claudio Gallia Thrombosis Research 15 April 1995 Volume 78 Issue 2 Pages 151 160 doi 10 1016 0049 3848 95 00043 7 Retrieved from https en wikipedia org w index php title Thromboxane B2 amp oldid 1174718744, wikipedia, wiki, book, books, library,

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