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Wikipedia

TUBGCP6

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP6
Identifiers
AliasesTUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDsOMIM: 610053 MGI: 2146071 HomoloGene: 32477 GeneCards: TUBGCP6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008658
NM_020461

NM_001163319

RefSeq (protein)

NP_065194

NP_001156791

Location (UCSC)Chr 22: 50.22 – 50.25 MbChr 15: 88.98 – 89.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128159 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051786 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
  6. ^ Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  7. ^ "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

Further reading edit

  • Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.


tubgcp6, gamma, tubulin, complex, component, protein, that, humans, encoded, gene, part, gamma, tubulin, complex, which, required, microtubule, nucleation, centrosome, identifiersaliases, gcp6, mccrp, mcphcr, mccrp1, tubulin, gamma, complex, associated, protei. Gamma tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene 5 6 7 It is part of the gamma tubulin complex which required for microtubule nucleation at the centrosome TUBGCP6IdentifiersAliasesTUBGCP6 GCP 6 GCP6 MCCRP MCPHCR MCCRP1 tubulin gamma complex associated protein 6External IDsOMIM 610053 MGI 2146071 HomoloGene 32477 GeneCards TUBGCP6Gene location Human Chr Chromosome 22 human 1 Band22q13 33Start50 217 689 bp 1 End50 245 023 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 E3Start88 982 560 bp 2 End89 007 315 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inanterior pituitaryright lobe of thyroid glandleft lobe of thyroid glandbody of pancreassural nerveright uterine tubecanal of the cervixbody of stomachspleenright adrenal glandTop expressed incerebellar cortexsuperior frontal gyrusyolk sacspermatocyteesophagusthymusneural tubelipsuperior cervical ganglionganglionic eminenceMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmicrotubule binding structural constituent of cytoskeleton microtubule minus end binding gamma tubulin bindingCellular componentcytoplasm cytosol centrosome spindle pole equatorial microtubule organizing center membrane microtubule organizing center spindle pole body microtubule extracellular exosome cytoskeleton gamma tubulin complex gamma tubulin small complexBiological processcentrosome duplication microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez85378328580EnsemblENSG00000128159ENSMUSG00000051786UniProtQ96RT7G5E8P0RefSeq mRNA NM 001008658NM 020461NM 001163319RefSeq protein NP 065194NP 001156791Location UCSC Chr 22 50 22 50 25 MbChr 15 88 98 89 01 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSee also editTubulin TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5References edit a b c GRCh38 Ensembl release 89 ENSG00000128159 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000051786 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Murphy SM Preble AM Patel UK O Connell KL Dias DP Moritz M Agard D Stults JT Stearns T 2001 GCP5 and GCP6 two new members of the human gamma tubulin complex Mol Biol Cell 12 11 3340 52 doi 10 1091 mbc 12 11 3340 PMC 60259 PMID 11694571 Hirosawa M Nagase T Murahashi Y Kikuno R Ohara O 2001 Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping DNA Res 8 1 1 9 doi 10 1093 dnares 8 1 1 PMID 11258795 Entrez Gene TUBGCP6 tubulin gamma complex associated protein 6 Further reading editOriolo AS Wald FA Canessa G Salas PJ 2007 GCP6 binds to intermediate filaments a novel function of keratins in the organization of microtubules in epithelial cells Mol Biol Cell 18 3 781 94 doi 10 1091 mbc E06 03 0201 PMC 1805110 PMID 17182859 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Brandenberger R Wei H Zhang S Lei S Murage J Fisk GJ Li Y Xu C Fang R Guegler K Rao MS Mandalam R Lebkowski J Stanton LW 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Dunham I Shimizu N Roe BA Chissoe S Hunt AR Collins JE Bruskiewich R Beare DM Clamp M Smink LJ Ainscough R Almeida JP Babbage A Bagguley C Bailey J Barlow K Bates KN Beasley O Bird CP Blakey S Bridgeman AM Buck D Burgess J Burrill WD O Brien KP 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TUBGCP6 amp oldid 1114133138, wikipedia, wiki, book, books, library,

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