fbpx
Wikipedia

TRIOBP

January 01, 1970

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.[5][6][7][8]

TRIOBP
Identifiers
AliasesTRIOBP, DFNB28, TAP68, TARA, dJ37E16.4, HRIHFB2122, TRIO and F-actin binding protein
External IDsOMIM: 609761; MGI: 1349410; HomoloGene: 5104; GeneCards: TRIOBP; OMA:TRIOBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez

11078

110253

Ensembl

ENSG00000100106

ENSMUSG00000033088

UniProt

Q9H2D6

Q99KW3

RefSeq (mRNA)

NM_138632
NM_001039141
NM_007032

NM_001024716
NM_001039155
NM_001039156
NM_138579

RefSeq (protein)

NP_001034230
NP_008963
NP_619538

NP_001019887
NP_001034244
NP_001034245
NP_613045

Location (UCSC)Chr 22: 37.7 – 37.78 MbChr 15: 78.83 – 78.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessive nonsyndromic deafness. Multiple alternatively-spliced transcript variants that would encode different isoforms have been found for this gene, though some transcripts may be subject to nonsense-mediated decay (NMD).[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100106 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033088 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seipel K, O'Brien SP, Iannotti E, Medley QG, Streuli M (Jan 2001). "Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization". J Cell Sci. 114 (Pt 2): 389–99. doi:10.1242/jcs.114.2.389. PMID 11148140.
  6. ^ Riazuddin S, Khan SN, Ahmed ZM, Ghosh M, Caution K, Nazli S, Kabra M, Zafar AU, Chen K, Naz S, Antonellis A, Pavan WJ, Green ED, Wilcox ER, Friedman PL, Morell RJ, Riazuddin S, Friedman TB (Dec 2005). "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness". Am J Hum Genet. 78 (1): 137–43. doi:10.1086/499164. PMC 1380211. PMID 16385457.
  7. ^ Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC, Kanaan M (Dec 2005). "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss". Am J Hum Genet. 78 (1): 144–52. doi:10.1086/499495. PMC 1380212. PMID 16385458.
  8. ^ a b "Entrez Gene: TRIOBP TRIO and F-actin binding protein".

Further reading edit

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Mayer BJ, Ren R, Clark KL, Baltimore D (1993). "A putative modular domain present in diverse signaling proteins". Cell. 73 (4): 629–30. doi:10.1016/0092-8674(93)90244-K. PMID 8500161. S2CID 44282241.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Li X, Lan J, Zhu Y, et al. (2007). "Expression, purification, and characterization of Tara, a novel telomere repeat-binding factor 1 (TRF1)-binding protein". Protein Expr. Purif. 55 (1): 84–92. doi:10.1016/j.pep.2007.05.004. PMID 17629495.


 

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
triobp, trio, actin, binding, protein, protein, that, humans, encoded, gene, identifiersaliases, dfnb28, tap68, tara, dj37e16, hrihfb2122, trio, actin, binding, proteinexternal, idsomim, 609761, 1349410, homologene, 5104, genecards, orthologsgene, location, hu. TRIO and F actin binding protein is a protein that in humans is encoded by the TRIOBP gene 5 6 7 8 TRIOBPIdentifiersAliasesTRIOBP DFNB28 TAP68 TARA dJ37E16 4 HRIHFB2122 TRIO and F actin binding proteinExternal IDsOMIM 609761 MGI 1349410 HomoloGene 5104 GeneCards TRIOBP OMA TRIOBP orthologsGene location Human Chr Chromosome 22 human 1 Band22q13 1Start37 697 048 bp 1 End37 776 556 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 E1 15 37 7 cMStart78 831 924 bp 2 End78 890 069 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlower lobe of lungright ventriclestromal cell of endometriumleft uterine tubecanal of the cervixright coronary arteryparotid glandsural nervemyometriumleft ventricleTop expressed insecondary oocytetriceps brachii muscleexternal carotid arterylipinternal carotid arteryyolk sacsternocleidomastoid muscletemporal muscleadrenal glandextraocular muscleMore reference expression dataBioGPSn aGene ontologyMolecular functionactin filament binding actin binding ubiquitin protein ligase binding myosin II bindingCellular componentfocal adhesion microtubule organizing center nucleus cytoskeleton midbody actin cytoskeleton cytoplasmBiological processbarbed end actin filament capping regulation of actin cytoskeleton organization cell cycle cell division positive regulation of substrate adhesion dependent cell spreading actin modification sensory perception of sound auditory receptor cell stereocilium organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez11078110253EnsemblENSG00000100106ENSMUSG00000033088UniProtQ9H2D6Q99KW3RefSeq mRNA NM 138632NM 001039141NM 007032NM 001024716NM 001039155NM 001039156NM 138579RefSeq protein NP 001034230NP 008963NP 619538NP 001019887NP 001034244NP 001034245NP 613045Location UCSC Chr 22 37 7 37 78 MbChr 15 78 83 78 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details September 2018 Learn how and when to remove this message This gene encodes a protein that interacts with Trio which is involved with neural tissue development and in controlling actin cytoskeleton organization cell motility and cell growth This trio binding protein also associates with F actin and stabilizes F actin structures Domains contained in this encoded protein are an N terminal pleckstrin homology domain and a C terminal coiled coil region Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene though some transcripts may be subject to nonsense mediated decay NMD 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000100106 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033088 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Seipel K O Brien SP Iannotti E Medley QG Streuli M Jan 2001 Tara a novel F actin binding protein associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization J Cell Sci 114 Pt 2 389 99 doi 10 1242 jcs 114 2 389 PMID 11148140 Riazuddin S Khan SN Ahmed ZM Ghosh M Caution K Nazli S Kabra M Zafar AU Chen K Naz S Antonellis A Pavan WJ Green ED Wilcox ER Friedman PL Morell RJ Riazuddin S Friedman TB Dec 2005 Mutations in TRIOBP which encodes a putative cytoskeletal organizing protein are associated with nonsyndromic recessive deafness Am J Hum Genet 78 1 137 43 doi 10 1086 499164 PMC 1380211 PMID 16385457 Shahin H Walsh T Sobe T Abu Sa ed J Abu Rayan A Lynch ED Lee MK Avraham KB King MC Kanaan M Dec 2005 Mutations in a novel isoform of TRIOBP that encodes a filamentous actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss Am J Hum Genet 78 1 144 52 doi 10 1086 499495 PMC 1380212 PMID 16385458 a b Entrez Gene TRIOBP TRIO and F actin binding protein Further reading editNakajima D Okazaki N Yamakawa H et al 2003 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Res 9 3 99 106 doi 10 1093 dnares 9 3 99 PMID 12168954 Mayer BJ Ren R Clark KL Baltimore D 1993 A putative modular domain present in diverse signaling proteins Cell 73 4 629 30 doi 10 1016 0092 8674 93 90244 K PMID 8500161 S2CID 44282241 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Ueki N Oda T Kondo M et al 1999 Selection system for genes encoding nuclear targeted proteins Nat Biotechnol 16 13 1338 42 doi 10 1038 4315 PMID 9853615 S2CID 20001769 Dunham I Shimizu N Roe BA et al 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Hartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Hirosawa M Nagase T Murahashi Y et al 2001 Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping DNA Res 8 1 1 9 doi 10 1093 dnares 8 1 1 PMID 11258795 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Wiemann S Arlt D Huber W et al 2004 From ORFeome to biology a functional genomics pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 Li X Lan J Zhu Y et al 2007 Expression purification and characterization of Tara a novel telomere repeat binding factor 1 TRF1 binding protein Protein Expr Purif 55 1 84 92 doi 10 1016 j pep 2007 05 004 PMID 17629495 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TRIOBP amp oldid 1114136896, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.