TRAF3IP3

TRAF3-interacting JNK-activating modulator is a protein that in humans is encoded by the TRAF3IP3 gene.^[5][6]

TRAF3IP3
Identifiers
Aliases	TRAF3IP3, T3JAM, TRAF3 interacting protein 3
External IDs	OMIM: 608255 MGI: 2441706 HomoloGene: 11885 GeneCards: TRAF3IP3
Gene location (Human) Chr. Chromosome 1 (human)^[1] Band 1q32.2 Start 209,756,032 bp^[1] End 209,782,320 bp^[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)^[2] Band 1|1 H6 Start 192,857,761 bp^[2] End 192,884,011 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen lymph node appendix bone marrow cells thymus spongy bone thymus gallbladder Top expressed in thymus blood spleen outer nuclear layer tongue inner nuclear layer bone marrow pharynx subcutaneous adipose tissue submandibular gland More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 80342 215243 Ensembl ENSG00000009790 ENSMUSG00000037318 UniProt Q9Y228 Q8C0G2 RefSeq (mRNA) NM_001287754 NM_025228 NM_001320143 NM_001320144 NM_153137 RefSeq (protein) NP_001274683 NP_001307072 NP_001307073 NP_079504 NP_694777 Location (UCSC) Chr 1: 209.76 – 209.78 Mb Chr 1: 192.86 – 192.88 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TRAF3IP3 has been shown to interact with STRN,^[7] MOBKL3,^[7] STK24^[7] and FAM40A.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000009790 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037318 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dadgostar H, Doyle SE, Shahangian A, Garcia DE, Cheng G (Oct 2003). "T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1)". FEBS Letters. 553 (3): 403–7. doi:10.1016/S0014-5793(03)01072-X. PMID 14572659. S2CID 8938949.
6. "Entrez Gene: TRAF3IP3 TRAF3 interacting protein 3".
7. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Vasilescu J, Zweitzig DR, Denis NJ, Smith JC, Ethier M, Haines DS, Figeys D (Jan 2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". Journal of Proteome Research. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
• Zhang C, Xie L, Cheng H, Wang Y (Feb 2007). "TRAF3 interacts with Smac/DIABLO and enhances the proapoptotic effect of Smac/DIABLO in cytoplasm". Acta Biochimica et Biophysica Sinica. 39 (2): 108–16. doi:10.1111/j.1745-7270.2007.00259.x. PMID 17277885. S2CID 19440495.
• Ma X, Wang X, Gao X, Wang L, Lu Y, Gao P, Deng W, Yu P, Ma J, Guo J, Cheng H, Zhang C, Shi T, Ma D (Sep 2007). "Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library". Life Sciences. 81 (14): 1141–51. doi:10.1016/j.lfs.2007.08.006. PMID 17868742.