This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000115540 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025979 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC310876. PMID 10810093.
^Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
^Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC3503316. PMID 11319234.
^ ab"Entrez Gene: PREI3 preimplantation protein 3".
^ abcdefghijkGoudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC2621004. PMID 18782753.
^Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
Further readingedit
Baillat G, Gaillard S, Castets F, Monneron A (May 2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I". The Journal of Biological Chemistry. 277 (21): 18961–6. doi:10.1074/jbc.M108818200. PMID 11872741.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
mobkl3, binder, kinase, activator, like, enzyme, that, humans, encoded, gene, mob4identifiersaliasesmob4, 2c4d, mob1, mob3, phocn, prei3, family, member, phoceinexternal, idsomim, 609361, 104899, homologene, 9116, genecards, mob4gene, location, human, chromoso. Mps one binder kinase activator like 3 is an enzyme that in humans is encoded by the MOBKL3 gene 5 6 7 8 MOB4IdentifiersAliasesMOB4 2C4D MOB1 MOB3 MOBKL3 PHOCN PREI3 CGI 95 MOB family member 4 phoceinExternal IDsOMIM 609361 MGI 104899 HomoloGene 9116 GeneCards MOB4Gene location Human Chr Chromosome 2 human 1 Band2q33 1Start197 515 571 bp 1 End197 553 699 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 C1 2Start55 170 390 bp 2 End55 194 058 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright ventriclethoracic diaphragmdeltoid musclevastus lateralis musclemyocardiumtriceps brachii muscletibialis anterior muscleBrodmann area 46ganglionic eminenceislet of LangerhansTop expressed inadrenal glandinterventricular septummedial ganglionic eminenceparotid glandleft lung lobevas deferensvastus lateralis muscleatrioventricular valveabdominal wallintercostal muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding metal ion binding kinase bindingCellular componentcytoplasm perinuclear region of cytoplasm Golgi cisterna membrane Golgi apparatus membrane cytosol neuronal cell body dendritic spineBiological processtransportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2584319070EnsemblENSG00000115540ENSMUSG00000025979UniProtQ9Y3A3Q6PEB6RefSeq mRNA NM 199482NM 001100819NM 001204094NM 015387NM 025283NM 001310585RefSeq protein NP 001094289NP 001191023NP 056202NP 955776NP 001297514NP 079559Location UCSC Chr 2 197 52 197 55 MbChr 1 55 17 55 19 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene was identified based on its similarity with the mouse counterpart Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation Alternatively spliced transcript variants encoding distinct isoforms have been observed 8 Interactions editMOBKL3 has been shown to interact with CTTNBP2NL 9 CTTNBP2 9 FAM40A 9 PDCD10 9 PPP2CA 9 RP6 213H19 1 9 STK24 9 10 STK25 9 STRN3 9 STRN 9 and TRAF3IP3 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000115540 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025979 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lai CH Chou CY Ch ang LY Liu CS Lin W May 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics Genome Research 10 5 703 13 doi 10 1101 gr 10 5 703 PMC 310876 PMID 10810093 Wiemann S Weil B Wellenreuther R Gassenhuber J Glassl S Ansorge W Bocher M Blocker H Bauersachs S Blum H Lauber J Dusterhoft A Beyer A Kohrer K Strack N Mewes HW Ottenwalder B Obermaier B Tampe J Heubner D Wambutt R Korn B Klein M Poustka A Mar 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Research 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Moreno CS Lane WS Pallas DC Jun 2001 A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family protein phosphatase 2A complexes The Journal of Biological Chemistry 276 26 24253 60 doi 10 1074 jbc M102398200 PMC 3503316 PMID 11319234 a b Entrez Gene PREI3 preimplantation protein 3 a b c d e f g h i j k Goudreault M D Ambrosio LM Kean MJ Mullin MJ Larsen BG Sanchez A Chaudhry S Chen GI Sicheri F Nesvizhskii AI Aebersold R Raught B Gingras AC Jan 2009 A PP2A phosphatase high density interaction network identifies a novel striatin interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 CCM3 protein Molecular amp Cellular Proteomics 8 1 157 71 doi 10 1074 mcp M800266 MCP200 PMC 2621004 PMID 18782753 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Molecular Systems Biology 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Further reading editBaillat G Gaillard S Castets F Monneron A May 2002 Interactions of phocein with nucleoside diphosphate kinase Eps15 and Dynamin I The Journal of Biological Chemistry 277 21 18961 6 doi 10 1074 jbc M108818200 PMID 11872741 Stelzl U Worm U Lalowski M Haenig C Brembeck FH Goehler H Stroedicke M Zenkner M Schoenherr A Koeppen S Timm J Mintzlaff S Abraham C Bock N Kietzmann S Goedde A Toksoz E Droege A Krobitsch S Korn B Birchmeier W Lehrach H Wanker EE Sep 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 S2CID 8235923 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Oct 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Molecular Systems Biology 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MOBKL3 amp oldid 1142688131, wikipedia, wiki, book, books, library,
