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CRTC1

January 01, 1970

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[5][6][7][8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[9] and various regions of the adult central nervous system.[10]

CRTC1
Identifiers
AliasesCRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDsOMIM: 607536; MGI: 2142523; HomoloGene: 41607; GeneCards: CRTC1; OMA:CRTC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

23373

382056

Ensembl

ENSG00000105662

ENSMUSG00000003575

UniProt

Q6UUV9

Q68ED7

RefSeq (mRNA)

NM_001098482
NM_015321
NM_025021

NM_001004062

RefSeq (protein)

NP_001091952
NP_056136

Location (UCSC)Chr 19: 18.68 – 18.78 MbChr 8: 70.84 – 70.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Not to be confused with mTORC1.

Clinical significance edit

Production of CRTC1 is blocked in Alzheimer's disease.[11]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105662 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003575 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
  6. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  7. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  8. ^ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
  9. ^ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
  10. ^ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  11. ^ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMC 6608295. PMID 24760838.

Further reading edit

  • Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  • Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. S2CID 30323449.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (Jan 2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Experimental Cell Research. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
  • Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M (Dec 2004). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Current Biology. 14 (23): 2156–61. Bibcode:2004CBio...14.2156B. doi:10.1016/j.cub.2004.11.002. PMID 15589160. S2CID 5934014.
  • Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (Jun 2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes, Chromosomes & Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701. S2CID 39267344.
  • Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ (Oct 2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation". Oncogene. 25 (45): 6128–32. doi:10.1038/sj.onc.1209627. PMID 16652146. S2CID 22409834.
  • Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (Jul 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
  • Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M (Jun 2006). "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade". The FEBS Journal. 273 (12): 2730–48. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901. S2CID 44953050.
  • Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (Jul 2006). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685. S2CID 17202179.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
crtc1, creb, regulated, transcription, coactivator, previously, referred, torc1, transducer, regulated, creb, activity, protein, that, humans, encoded, gene, expressed, limited, number, tissues, that, include, fetal, brain, liver, adult, heart, skeletal, muscl. CREB regulated transcription coactivator 1 CRTC1 previously referred to as TORC1 Transducer Of Regulated CREB activity 1 is a protein that in humans is encoded by the CRTC1 gene 5 6 7 8 It is expressed in a limited number of tissues that include fetal brain and liver and adult heart skeletal muscles liver and salivary glands 9 and various regions of the adult central nervous system 10 CRTC1IdentifiersAliasesCRTC1 MECT1 TORC 1 TORC1 WAMTP1 CREB regulated transcription coactivator 1 MAML2 Mam 2External IDsOMIM 607536 MGI 2142523 HomoloGene 41607 GeneCards CRTC1 OMA CRTC1 orthologsGene location Human Chr Chromosome 19 human 1 Band19p13 11Start18 683 678 bp 1 End18 782 333 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 B3 3Start70 835 005 bp 2 End70 892 229 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inBrodmann area 10middle frontal gyrusfrontal polecerebellar vermisnucleus accumbenscingulate gyrusamygdalaputamenBrodmann area 9caudate nucleusTop expressed insuperior frontal gyruscerebellar cortexhippocampus propersecondary oocytenucleus accumbensyolk sacneural tubeprefrontal cortexliptemporal lobeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding cAMP response element binding protein bindingCellular componentneuronal cell body plasma membrane dendrite synapse nucleus nucleoplasm cytoplasm cytosol nuclear body postsynaptic density glutamatergic synapseBiological processpositive regulation of CREB transcription factor activity viral process positive regulation of dendrite development memory entrainment of circadian clock by photoperiod protein homotetramerization positive regulation of long term synaptic potentiation transcription DNA templated positive regulation of transcription by RNA polymerase II rhythmic process regulation of transcription DNA templated energy homeostasis negative regulation of membrane hyperpolarization postsynapse to nucleus signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez23373382056EnsemblENSG00000105662ENSMUSG00000003575UniProtQ6UUV9Q68ED7RefSeq mRNA NM 001098482NM 015321NM 025021NM 001004062RefSeq protein NP 001091952NP 056136NP 001004062NP 001391344NP 001391345NP 001391346NP 001391347NP 001391348NP 001391349NP 001391350NP 001391351NP 001391352NP 001391353NP 001391354NP 001391355NP 001391356NP 001391357NP 001391358NP 001391359Location UCSC Chr 19 18 68 18 78 MbChr 8 70 84 70 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Not to be confused with mTORC1 Contents 1 Clinical significance 2 See also 3 References 4 Further reading 5 External linksClinical significance editProduction of CRTC1 is blocked in Alzheimer s disease 11 See also editTranscription coregulatorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000105662 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000003575 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Tonon G Modi S Wu L Kubo A Coxon AB Komiya T O Neil K Stover K El Naggar A Griffin JD Kirsch IR Kaye FJ Feb 2003 t 11 19 q21 p13 translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway Nature Genetics 33 2 208 13 doi 10 1038 ng1083 PMID 12539049 S2CID 23417795 Conkright MD Canettieri G Screaton R Guzman E Miraglia L Hogenesch JB Montminy M Aug 2003 TORCs transducers of regulated CREB activity Molecular Cell 12 2 413 23 doi 10 1016 j molcel 2003 08 013 PMID 14536081 Iourgenko V Zhang W Mickanin C Daly I Jiang C Hexham JM Orth AP Miraglia L Meltzer J Garza D Chirn GW McWhinnie E Cohen D Skelton J Terry R Yu Y Bodian D Buxton FP Zhu J Song C Labow MA Oct 2003 Identification of a family of cAMP response element binding protein coactivators by genome scale functional analysis in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 100 21 12147 52 doi 10 1073 pnas 1932773100 PMC 218727 PMID 14506290 Entrez Gene CRTC1 CREB regulated transcription coactivator 1 Huret J L CRTC1 CREB regulated transcription coactivator 1 Atlas of Genetics and Cytogenetics in Oncology and Haematology INSERM U 935 Genetics Dept Medical Information University Hospital of Poitiers Kovacs KA Steullet P Steinmann M Do KQ Magistretti PJ Halfon O Cardinaux JR Mar 2007 TORC1 is a calcium and cAMP sensitive coincidence detector involved in hippocampal long term synaptic plasticity Proceedings of the National Academy of Sciences of the United States of America 104 11 4700 5 Bibcode 2007PNAS 104 4700K doi 10 1073 pnas 0607524104 PMC 1838663 PMID 17360587 Parra Damas A Valero J Chen M Espana J Martin E Ferrer I Rodriguez Alvarez J Saura CA Apr 2014 Crtc1 activates a transcriptional program deregulated at early Alzheimer s disease related stages The Journal of Neuroscience 34 17 5776 87 doi 10 1523 JNEUROSCI 5288 13 2014 PMC 6608295 PMID 24760838 Further reading editKovacs KA Steullet P Steinmann M Do KQ Magistretti PJ Halfon O Cardinaux JR Mar 2007 TORC1 is a calcium and cAMP sensitive coincidence detector involved in hippocampal long term synaptic plasticity Proceedings of the National Academy of Sciences of the United States of America 104 11 4700 5 Bibcode 2007PNAS 104 4700K doi 10 1073 pnas 0607524104 PMC 1838663 PMID 17360587 Takemori H Kajimura J Okamoto M Jul 2007 TORC SIK cascade regulates CREB activity through the basic leucine zipper domain The FEBS Journal 274 13 3202 9 doi 10 1111 j 1742 4658 2007 05889 x PMID 17565599 S2CID 30323449 Bonaldo MF Lennon G Soares MB Sep 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Research 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Ishikawa K Nagase T Suyama M Miyajima N Tanaka A Kotani H Nomura N Ohara O Jun 1998 Prediction of the coding sequences of unidentified human genes X The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro DNA Research 5 3 169 76 doi 10 1093 dnares 5 3 169 PMID 9734811 Enlund F Behboudi A Andren Y Oberg C Lendahl U Mark J Stenman G Jan 2004 Altered Notch signaling resulting from expression of a WAMTP1 MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin s tumors Experimental Cell Research 292 1 21 8 doi 10 1016 j yexcr 2003 09 007 PMID 14720503 Jin J Smith FD Stark C Wells CD Fawcett JP Kulkarni S Metalnikov P O Donnell P Taylor P Taylor L Zougman A Woodgett JR Langeberg LK Scott JD Pawson T Aug 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization PDF Current Biology 14 16 1436 50 Bibcode 2004CBio 14 1436J doi 10 1016 j cub 2004 07 051 PMID 15324660 S2CID 2371325 Screaton RA Conkright MD Katoh Y Best JL Canettieri G Jeffries S Guzman E Niessen S Yates JR Takemori H Okamoto M Montminy M Oct 2004 The CREB coactivator TORC2 functions as a calcium and cAMP sensitive coincidence detector Cell 119 1 61 74 doi 10 1016 j cell 2004 09 015 PMID 15454081 S2CID 18616459 Bittinger MA McWhinnie E Meltzer J Iourgenko V Latario B Liu X Chen CH Song C Garza D Labow M Dec 2004 Activation of cAMP response element mediated gene expression by regulated nuclear transport of TORC proteins Current Biology 14 23 2156 61 Bibcode 2004CBio 14 2156B doi 10 1016 j cub 2004 11 002 PMID 15589160 S2CID 5934014 Behboudi A Winnes M Gorunova L van den Oord JJ Mertens F Enlund F Stenman G Jun 2005 Clear cell hidradenoma of the skin a third tumor type with a t 11 19 associated TORC1 MAML2 gene fusion Genes Chromosomes amp Cancer 43 2 202 5 doi 10 1002 gcc 20168 PMID 15729701 S2CID 39267344 Komiya T Park Y Modi S Coxon AB Oh H Kaye FJ Oct 2006 Sustained expression of Mect1 Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t 11 19 translocation Oncogene 25 45 6128 32 doi 10 1038 sj onc 1209627 PMID 16652146 S2CID 22409834 Siu YT Chin KT Siu KL Yee Wai Choy E Jeang KT Jin DY Jul 2006 TORC1 and TORC2 coactivators are required for tax activation of the human T cell leukemia virus type 1 long terminal repeats Journal of Virology 80 14 7052 9 doi 10 1128 JVI 00103 06 PMC 1489057 PMID 16809310 Katoh Y Takemori H Lin XZ Tamura M Muraoka M Satoh T Tsuchiya Y Min L Doi J Miyauchi A Witters LA Nakamura H Okamoto M Jun 2006 Silencing the constitutive active transcription factor CREB by the LKB1 SIK signaling cascade The FEBS Journal 273 12 2730 48 doi 10 1111 j 1742 4658 2006 05291 x PMID 16817901 S2CID 44953050 Okabe M Miyabe S Nagatsuka H Terada A Hanai N Yokoi M Shimozato K Eimoto T Nakamura S Nagai N Hasegawa Y Inagaki H Jul 2006 MECT1 MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma Clinical Cancer Research 12 13 3902 7 doi 10 1158 1078 0432 CCR 05 2376 PMID 16818685 S2CID 17202179 External links editCRTC1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CRTC1 genome location and CRTC1 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CRTC1 amp oldid 1215863448, wikipedia, wiki, book, books, library,

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