The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000025772 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000018322 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.
^ ab"Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".
Further readingedit
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Young JC, Obermann WM, Hartl FU (1998). "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. doi:10.1074/jbc.273.29.18007. PMID 9660753.
Chewawiwat N, Yano M, Terada K, et al. (1999). "Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells". J. Biochem. 125 (4): 721–7. doi:10.1093/oxfordjournals.jbchem.a022342. PMID 10101285.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shimokawa T, Matsushima S, Tsunoda T, et al. (2006). "Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". Int. J. Oncol. 29 (2): 381–6. doi:10.3892/ijo.29.2.381. PMID 16820880.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
tomm34, mitochondrial, import, receptor, subunit, tom34, protein, that, humans, encoded, gene, identifiersaliases, htom34p, tom34, urcc3, translocase, outer, mitochondrial, membrane, 34external, idsomim, 616049, 1914395, homologene, 4956, genecards, orthologsg. Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene 5 6 TOMM34IdentifiersAliasesTOMM34 HTOM34P TOM34 URCC3 translocase of outer mitochondrial membrane 34External IDsOMIM 616049 MGI 1914395 HomoloGene 4956 GeneCards TOMM34 OMA TOMM34 orthologsGene location Human Chr Chromosome 20 human 1 Band20q13 12Start44 942 130 bp 1 End44 960 397 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 H3Start163 895 460 bp 2 End163 913 089 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inislet of Langerhansnucleus accumbensright uterine tubecaudate nucleusleft adrenal glandputamencingulate gyrusprefrontal cortexBrodmann area 9anterior pituitaryTop expressed inbloodcumulus cellsubiculumpontine nucleisuperior frontal gyruspituitary glandankle jointpineal glandutricleendocardial cushionMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding heat shock protein bindingCellular componentintegral component of membrane mitochondrial outer membrane membrane mitochondrion nucleus nucleoplasm cytoplasm cytosolBiological processprotein targeting to mitochondrionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1095367145EnsemblENSG00000025772ENSMUSG00000018322UniProtQ15785Q9CYG7RefSeq mRNA NM 006809NM 001291155NM 025996RefSeq protein NP 006800NP 001278084NP 080272Location UCSC Chr 20 44 94 44 96 MbChr 2 163 9 163 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is involved in the import of precursor proteins into mitochondria The encoded protein has a chaperone like activity binding the mature portion of unfolded proteins and aiding their import into mitochondria This protein which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane has a weak ATPase activity and contains 6 TPR repeats 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000025772 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000018322 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nuttall SD Hanson BJ Mori M Hoogenraad NJ Oct 1997 hTom34 a novel translocase for the import of proteins into human mitochondria DNA Cell Biol 16 9 1067 74 doi 10 1089 dna 1997 16 1067 PMID 9324309 a b Entrez Gene TOMM34 translocase of outer mitochondrial membrane 34 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Young JC Obermann WM Hartl FU 1998 Specific binding of tetratricopeptide repeat proteins to the C terminal 12 kDa domain of hsp90 J Biol Chem 273 29 18007 10 doi 10 1074 jbc 273 29 18007 PMID 9660753 Chewawiwat N Yano M Terada K et al 1999 Characterization of the novel mitochondrial protein import component Tom34 in mammalian cells J Biochem 125 4 721 7 doi 10 1093 oxfordjournals jbchem a022342 PMID 10101285 Fossey SC Mychaleckyj JC Pendleton JK et al 2001 A high resolution 6 0 megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 Genomics 76 1 3 45 57 doi 10 1006 geno 2001 6584 PMID 11549316 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Mukhopadhyay A Avramova LV Weiner H 2002 Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins Arch Biochem Biophys 400 1 97 104 doi 10 1006 abbi 2002 2777 PMID 11913975 Yang CS Weiner H 2002 Yeast two hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol Arch Biochem Biophys 400 1 105 10 doi 10 1006 abbi 2002 2778 PMID 11913976 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Shimokawa T Matsushima S Tsunoda T et al 2006 Identification of TOMM34 which shows elevated expression in the majority of human colon cancers as a novel drug target Int J Oncol 29 2 381 6 doi 10 3892 ijo 29 2 381 PMID 16820880 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TOMM34 amp oldid 1116596405, wikipedia, wiki, book, books, library,
