The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000120337 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000066755 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kwon B, Yu KY, Ni J, Yu GL, Jang IK, Kim YJ, Xing L, Liu D, Wang SX, Kwon BS (Mar 1999). "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand". J Biol Chem. 274 (10): 6056–61. doi:10.1074/jbc.274.10.6056. PMID 10037686.
^Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A (Apr 1999). "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR". Curr Biol. 9 (4): 215–8. Bibcode:1999CBio....9..215G. doi:10.1016/S0960-9822(99)80093-1. PMID 10074428. S2CID 110695.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Yu KY, Kim HS, Song SY, et al. (2003). "Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells". Biochem. Biophys. Res. Commun. 310 (2): 433–8. doi:10.1016/j.bbrc.2003.09.024. PMID 14521928.
Kim BJ, Li Z, Fariss RN, et al. (2004). "Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors". Invest. Ophthalmol. Vis. Sci. 45 (9): 3170–6. doi:10.1167/iovs.03-0919. PMID 15326137.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Nardelli B, Zaritskaya L, McAuliffe W, et al. (2006). "Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells". Endocrinology. 147 (1): 70–8. doi:10.1210/en.2005-0518. PMID 16179414.
Hanabuchi S, Watanabe N, Wang YH, et al. (2006). "Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)". Blood. 107 (9): 3617–23. doi:10.1182/blood-2005-08-3419. PMID 16397134.
Mahesh SP, Li Z, Liu B, et al. (2006). "Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines". Eur. J. Immunol. 36 (8): 2128–38. doi:10.1002/eji.200635893. PMID 16874737.
Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, et al. (2006). "Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis". Acta Derm. Venereol. 86 (5): 393–8. doi:10.2340/00015555-0118. PMID 16955181.
Baltz KM, Krusch M, Bringmann A, et al. (2007). "Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions". FASEB J. 21 (10): 2442–54. doi:10.1096/fj.06-7724com. PMID 17360848. S2CID 6617086.
Tuyaerts S, Van Meirvenne S, Bonehill A, et al. (2007). "Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells". J. Leukoc. Biol. 82 (1): 93–105. doi:10.1189/jlb.0906568. PMID 17449724. S2CID 19288807.
Bae EM, Kim WJ, Suk K, et al. (2007). "Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages". Mol. Immunol. 45 (2): 523–33. doi:10.1016/j.molimm.2007.05.013. PMID 17602748.
Kim YS, Jung HW, Choi J, et al. (2007). "Expression of AITR and AITR ligand in breast cancer patients". Oncol. Rep. 18 (5): 1189–94. doi:10.3892/or.18.5.1189. PMID 17914571.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
tnfsf18, tumor, necrosis, factor, ligand, superfamily, member, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2q1m, 2r30, 2r32, 3b93, 3b94identifiersaliases, aitrl, gitrl, hgitrl, tnlg2a, tumor, necrosis, f. Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene 5 6 7 TNFSF18Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2Q1M 2R30 2R32 3B93 3B94IdentifiersAliasesTNFSF18 AITRL GITRL TL6 hGITRL TNLG2A tumor necrosis factor superfamily member 18 TNF superfamily member 18External IDsOMIM 603898 MGI 2673064 HomoloGene 3732 GeneCards TNFSF18Gene location Human Chr Chromosome 1 human 1 Band1q25 1Start173 039 202 bp 1 End173 050 941 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H2 1 1 69 75 cMStart161 322 224 bp 2 End161 332 859 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingallbladderstromal cell of endometriumrectumprefrontal cortexislet of LangerhansBrodmann area 9smooth muscle tissueduodenumlymph nodeappendixTop expressed inuteruszone of skinlipspermatidspleenembryoMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytokine activity signaling receptor binding protein binding tumor necrosis factor receptor superfamily binding identical protein bindingCellular componentintegral component of membrane membrane plasma membrane extracellular space cell surfaceBiological processadaptive immune response positive regulation of leukocyte migration immune system process cell cell signaling negative regulation of apoptotic process signal transduction positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity T cell proliferation involved in immune response tumor necrosis factor mediated signaling pathway regulation of T cell proliferation positive regulation of cell adhesion positive regulation of NF kappaB transcription factor activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8995240873EnsemblENSG00000120337ENSMUSG00000066755UniProtQ9UNG2Q7TS55RefSeq mRNA NM 005092NM 183391RefSeq protein NP 005083NP 899247Location UCSC Chr 1 173 04 173 05 MbChr 1 161 32 161 33 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor TNF ligand family This cytokine is a ligand for receptor TNFRSF18 AITR GITR It has been shown to modulate T lymphocyte survival in peripheral tissues This cytokine is also found to be expressed in endothelial cells and is thought to be important for interaction between T lymphocytes and endothelial cells 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000120337 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000066755 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kwon B Yu KY Ni J Yu GL Jang IK Kim YJ Xing L Liu D Wang SX Kwon BS Mar 1999 Identification of a novel activation inducible protein of the tumor necrosis factor receptor superfamily and its ligand J Biol Chem 274 10 6056 61 doi 10 1074 jbc 274 10 6056 PMID 10037686 Gurney AL Marsters SA Huang RM Pitti RM Mark DT Baldwin DT Gray AM Dowd AD Brush AD Heldens AD Schow AD Goddard AD Wood WI Baker KP Godowski PJ Ashkenazi A Apr 1999 Identification of a new member of the tumor necrosis factor family and its receptor a human ortholog of mouse GITR Curr Biol 9 4 215 8 Bibcode 1999CBio 9 215G doi 10 1016 S0960 9822 99 80093 1 PMID 10074428 S2CID 110695 a b Entrez Gene TNFSF18 tumor necrosis factor ligand superfamily member 18 Further reading editStrausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Clark HF Gurney AL Abaya E et al 2003 The Secreted Protein Discovery Initiative SPDI a Large Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins A Bioinformatics Assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Yu KY Kim HS Song SY et al 2003 Identification of a ligand for glucocorticoid induced tumor necrosis factor receptor constitutively expressed in dendritic cells Biochem Biophys Res Commun 310 2 433 8 doi 10 1016 j bbrc 2003 09 024 PMID 14521928 Kim BJ Li Z Fariss RN et al 2004 Constitutive and cytokine induced GITR ligand expression on human retinal pigment epithelium and photoreceptors Invest Ophthalmol Vis Sci 45 9 3170 6 doi 10 1167 iovs 03 0919 PMID 15326137 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Nardelli B Zaritskaya L McAuliffe W et al 2006 Osteostat tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells Endocrinology 147 1 70 8 doi 10 1210 en 2005 0518 PMID 16179414 Hanabuchi S Watanabe N Wang YH et al 2006 Human plasmacytoid predendritic cells activate NK cells through glucocorticoid induced tumor necrosis factor receptor ligand GITRL Blood 107 9 3617 23 doi 10 1182 blood 2005 08 3419 PMID 16397134 Mahesh SP Li Z Liu B et al 2006 Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines Eur J Immunol 36 8 2128 38 doi 10 1002 eji 200635893 PMID 16874737 Baumgartner Nielsen J Vestergaard C Thestrup Pedersen K et al 2006 Glucocorticoid induced tumour necrosis factor receptor GITR and its ligand GITRL in atopic dermatitis Acta Derm Venereol 86 5 393 8 doi 10 2340 00015555 0118 PMID 16955181 Baltz KM Krusch M Bringmann A et al 2007 Cancer immunoediting by GITR glucocorticoid induced TNF related protein ligand in humans NK cell tumor cell interactions FASEB J 21 10 2442 54 doi 10 1096 fj 06 7724com PMID 17360848 S2CID 6617086 Tuyaerts S Van Meirvenne S Bonehill A et al 2007 Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4 CD25 regulatory T cells J Leukoc Biol 82 1 93 105 doi 10 1189 jlb 0906568 PMID 17449724 S2CID 19288807 Bae EM Kim WJ Suk K et al 2007 Reverse signaling initiated from GITRL induces NF kappaB activation through ERK in the inflammatory activation of macrophages Mol Immunol 45 2 523 33 doi 10 1016 j molimm 2007 05 013 PMID 17602748 Kim YS Jung HW Choi J et al 2007 Expression of AITR and AITR ligand in breast cancer patients Oncol Rep 18 5 1189 94 doi 10 3892 or 18 5 1189 PMID 17914571 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title TNFSF18 amp oldid 1215920872, wikipedia, wiki, book, books, library,
