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Stephen J. Challacombe

January 01, 1970

Stephen James Challacombe FRC(Path), FDSRCS, FMedSci, (born April 1946) is professor of oral medicine at King's College in London, best known for research in oromucosal immunology and for developing the Challacombe scale for measuring the extent of dryness of the mouth. He led the team that laid out research challenges of global health inequalities and oral health, particularly relating to the oral manifestations of HIV.

Professor
Stephen J. Challacombe
FRC(Path), FDSRCS, FMedSci
Professor Stephen Challacombe (2019)
BornApril 1946
NationalityBritish
EducationGuy's Hospital Dental School
Known for
SpouseTina
Children2
Scientific career
Fields
  • Oromucosal immunology
  • Global health inequalities
Institutions

Challacombe was the Martin Rushton Professor of Oral Medicine at King's College, London and the University of London, a consultant in diagnostic microbiology and immunology to Guys & St Thomas Hospitals, and Dean for external affairs at King's College London Health Schools.

He has been an author, co-author, editor and co-editor of a number of publications and a recipient of several awards and fellowships. Medical societies of which he has been president include the International Association for Dental Research, British Society for Oral and Dental Research, European Association of Oral Medicine and the Hunterian Society, and the world's oldest rugby club, Guy's Hospital RFC.

Early life edit

Stephen Challacombe was born in April 1946. He attended Culford School, where he played sports including rugby.[1]

Mucosal immunology edit

He initially worked in the field of immunology.[2] In 1978, he was appointed assistant professor and senior research fellow in the Department of Immunology at the Mayo Clinic in the United States,[3] and completed the fellowship in 1979.[4]

From 1984 to 2011, he was consultant in diagnostic microbiology and immunology to Guys & St Thomas Hospitals.[5] During this time, he became professor of oral medicine in the department of Oral Medicine and Pathology at Guy's Hospital in 1986 and the Martin Rushton Professor of oral medicine in 1988.[2][6]

Later career edit

Challacombe was appointed Director of External Strategy at the Dental Institute in 2005 and a year later became Dean for King's College London KCL External Affairs, holding both posts until 2011.[5][7]

His experience has also included coordinating conferences and university departments, managing grants, finances and research, and teaching.[3]

Challacombe scale edit

He developed the Challacombe scale for measuring the extent of dryness of the mouth in human beings. It was launched in 2011 at Tylney Hall in Hampshire[8] and has become widely used as a medical tool for assessing and monitoring dry mouth.[9][10][11]

Global oral health edit

Challacombe became involved in clinical research in oral HIV and AIDS, and has chaired international workshops on the oral manifestations of HIV infection in the UK, South Africa, Thailand, China, and India. In 1991 and 1993, he contributed to the consensus meeting on the classification of oral lesions in HIV.[1][3]

He was chairman of the International Steering Committee on Oral Health and Disease in HIV infection between 2000 and 2017.[3]

In 2011, he led the team that laid out research challenges of global health inequalities and oral health, particularly relating to Noma, tuberculosis, sexually transmitted disease and HIV, four of the most serious global oral health infections.[12][13][14] With regards to clinical signs in the mouth in AIDS, he identified a significant role for dentists.[13]

Later, using Sierra Leone as a case study to develop oral health programmes in low-income countries, he worked with the King's Sierra Leone Partnership's dentistry section,[15] as a member of The Kings Centre for Global Health.[1]

In 2020, he co-authored a review which proposed using povidone-iodine to reduce cross-infectivity of COVID-19,[16] and highlighted the role of saliva in the transmission of the disease.[17]

History of medicine edit

As a historian of medicine, his lectures have included a series on the London medical students at Belsen.[18]

Awards and honours edit

Awards edit

Challacombe is a recipient of a number of awards including:

  • Colgate (Hatton) Research Prize, British Division, IADR (1977)[5]
  • Kendall-Hench Research Fellowship, Mayo Clinic, Minnesota, USA (1978)[5]
  • Basic Research in Oral Science Award, IADR. (1981)[5]
  • Distinguished Scientist Award for Experimental Pathology, IADR, (1997)[5]
  • DSc (h.c.), University of Athens (2012)[5]
  • American Academy of Oral Medicine Samuel Charles Miller award (2018)[5][19]
  • Distinguished Alumni Award of the Mayo Clinic (2017).[4]

Presidencies edit

 
Stephen Challacombe, Hunterian Society (October 2019)

He has been president of:

He has also been president of the world's oldest rugby club, Guy's Hospital RFC.[1][20]

Chairmanships edit

He was chairman of:

Fellowships edit

He is a fellow of the:

Personal life edit

He is married to Tina and they have two children.[1]

In 2013, he joined the Board of Governors of Culford School.[1] He also continues to support students of the world's oldest rugby club, Guy's Hospital RFC.[22]

Writing edit

He has been an author, co-author, editor and co-editor of a number of publications including nine books, over 240 peer-reviewed research papers and 160 other works on various aspects of oral and maxillofacial medicine.[3] These have included publications on induction of secretory immune responses, oral tolerance and on immunological aspects of the oral cavity.[2] His interest on mucosal immunity in HIV and how HIV can present with signs in the mouth, has resulted in over 25 research articles.[3]

Selected publications edit

Articles edit

  • Challacombe, S J; Tomasi, T B (1 December 1980). "Systemic tolerance and secretory immunity after oral immunization". Journal of Experimental Medicine. 152 (6). Rockefeller University Press: 1459–1472. doi:10.1084/jem.152.6.1459. ISSN 0022-1007. PMC 2186016. PMID 7452148. S2CID 17098839.
  • “Salivary Antibodies and Systemic Tolerance in Mice after Oral Immunization with Bacterial Antigens”, Annals of the New York Academy of Sciences. June 1983, doi:10.1111/j.1749-6632.1983.tb26868.x
  • "Oral mucosal lesions : what the general practitioner needs to know", Wynnum, Qld (2009), DVD-ROM
  • "Beijing Declaration 2009". Advances in Dental Research, 25 March 2011, doi:10.1177/0022034511399085
  • "Clinical assessment of oral dryness: development of a scoring system related to salivary flow and mucosal wetness". Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology. November 2012, Volume 114, Issue 5, Pages 597–603, doi:10.1016/j.oooo.2012.05.009. (With S.M. Osailan, R. Pramanik, B. P. Shirlawb, G.B. Proctor)
  • "The mouth and AIDS: lessons learned and emerging challenges in global oral health: introduction". Oral Diseases, (2016) 22 (Suppl. 1), 5–6. doi:10.1111/odi.12426. (With AR Tappuni and K Ranganathan)
  • "Global oral inequalities in HIV infection". Oral Diseases (2016) 22 (Suppl. 1), pp. 35–41 doi:10.1111/odi.12408
  • "Dry Mouth and Clinical Oral Dryness Scoring Systems". Primary Dental Journal, 2016 Feb 1;5(1):77-79. PMID 29029657. (With P. Das)
  • "Fortitude and resilience in service of the population: a case study of dental professionals striving for health in Sierra Leone". British Dental Journal Open. 2019; 5: 7. Published online 2019 May 13. doi:10.1038/s41405-019-0011-2

Books edit

  • Advances in Mucosal Immunology : Proceedings of the Fifth International Congress of Mucosal Immunology, co-authored with Thomas T MacDonald, Paul W Bland, Christopher R Stokes, Richard V Heatley, Allan Mcl Mowat Dordrecht, Springer Netherlands, (1990), ISBN 9789400918481, OCLC 840304723
  • Food allergy, co-authored with Jonathan Brostoff, Saunders, (1998), Clinics in immunology and allergy, v. 2, no. 1. OCLC 9254958
  • Food Allergy and Intolerance, co-authored with Jonathan Brostoff, Saunders (2002) ISBN 9780702020384
  • Oral and Maxillofacial Medicine: The Basis of Diagnosis and Treatment, Churchill Livingstone

References edit

  1. ^ a b c d e f "Culford School; Meet the Governors". www.culford.co.uk. Retrieved 23 May 2020.
  2. ^ a b c Challacombe, S.; Bland, P.; Stokes, C.; Heatley, A.; Mowat, A. (1990). Advances in Mucosal Immunology: Proceedings of the Fifth International Congress of Mucosal Immunology. Springer Science & Business Media. ISBN 0-7462-0113-3.
  3. ^ a b c d e f "World Workshop - Global Overview of HIV". ww8aids.org. Faculty of Dentistry Universitas Padjadjaran. 2018. Retrieved 26 June 2019.
  4. ^ a b "Mayo Clinic announces 2017 Distinguished Alumni Awards". newsnetwork.mayoclinic.org. Retrieved 26 June 2019.
  5. ^ a b c d e f g h i j k l m n o p q r s t u v "Professor Stephen Challacombe". www.kcl.ac.uk. Retrieved 25 June 2019.
  6. ^ a b "Stephen Challacombe". Linked in. Retrieved 30 July 2019.
  7. ^ "In Touch Autumn 2013". Issuu. Retrieved 11 July 2019.
  8. ^ "Dry mouth scale launched". British Dental Journal. 211 (8): 351. 21 October 2011. doi:10.1038/sj.bdj.2011.884. ISSN 1476-5373.
  9. ^ Meurman, Jukka H. (2018). Translational Oral Health Research. Springer. p. 15. ISBN 978-3-319-78204-1.
  10. ^ Katz, James D.; Walitt, Brian (2018). Rheumatic Diseases in Older Adults, An Issue of Rheumatic Disease Clinics of North America E-Book. Elsevier Health Sciences. p. 426. ISBN 9780323613545.
  11. ^ Banerjee, Avijit; Watson, Timothy F. (2015). Pickard's Guide to Minimally Invasive Operative Dentistry. Oxford University Press. ISBN 9780198712091.
  12. ^ Challacombe, S.; Chidzonga, M.; Glick, M.; Hodgson, T.; Magalhães, M.; Shiboski, C.; Owotade, F.; Ranganathan, R.; Naidoo, S. (May 2011). Williams, D.M. (ed.). "Global Oral Health Inequalities: Oral Infections–Challenges and Approaches". Advances in Dental Research. 23 (2): 227–236. doi:10.1177/0022034511402081. ISSN 0895-9374. PMID 21490235. S2CID 5256917.
  13. ^ a b Wilson, Nairn; Dunne, Stephen (2018). Manual of Clinical Procedures in Dentistry. John Wiley & Sons. p. 30. ISBN 9780470670521.
  14. ^ Tappuni, A. R.; Shiboski, C. (2016). "Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS" (PDF). Oral Diseases. 22 (S1): 211–214. doi:10.1111/odi.12459. ISSN 1601-0825. PMID 27109289.
  15. ^ "Dentistry – King's Sierra Leone Partnership". Retrieved 11 July 2019.
  16. ^ Vlessides, Michael (12 June 2020). "Can Mouthwash Douse the Spread of COVID-19?". Medscape. Retrieved 5 July 2020.
  17. ^ "Joint international virtual seminar: Saliva as an important body fluid in the COVID-19 pandemic". www.kcl.ac.uk. Retrieved 3 October 2020.
  18. ^ Burns, Judith (15 April 2020). "The medical students who saved lives at Belsen". BBC News. Retrieved 23 May 2020.
  19. ^ "History of Awards - Samuel Charles Miller". www.aaom.com. Retrieved 26 June 2019.
  20. ^ . 9 April 2009. Archived from the original on 9 April 2009. Retrieved 10 July 2019.
  21. ^ "Fellowship for Professor Challacombe". British Dental Journal. 209 (5): 202. 11 September 2010. doi:10.1038/sj.bdj.2010.782. ISSN 1476-5373. S2CID 33400233.
  22. ^ "King's College London Association / KCLA Sports Dinner". www.kcla.co.uk. Retrieved 26 June 2019.

Further reading edit

  • "The Medical Research Council's Review of the Future of the National Institute for Medical Research", Fourth Report of Session 2004–05, Volume II, Oral and written evidence

January 01, 1970
stephen, challacombe, stephen, james, challacombe, path, fdsrcs, fmedsci, born, april, 1946, professor, oral, medicine, king, college, london, best, known, research, oromucosal, immunology, developing, challacombe, scale, measuring, extent, dryness, mouth, tea. Stephen James Challacombe FRC Path FDSRCS FMedSci born April 1946 is professor of oral medicine at King s College in London best known for research in oromucosal immunology and for developing the Challacombe scale for measuring the extent of dryness of the mouth He led the team that laid out research challenges of global health inequalities and oral health particularly relating to the oral manifestations of HIV ProfessorStephen J ChallacombeFRC Path FDSRCS FMedSciProfessor Stephen Challacombe 2019 BornApril 1946NationalityBritishEducationGuy s Hospital Dental SchoolKnown forChallacombe scaleOral healthSpouseTinaChildren2Scientific careerFieldsOromucosal immunologyGlobal health inequalitiesInstitutionsKing s College London UMDS Guy s Hospital Challacombe was the Martin Rushton Professor of Oral Medicine at King s College London and the University of London a consultant in diagnostic microbiology and immunology to Guys amp St Thomas Hospitals and Dean for external affairs at King s College London Health Schools He has been an author co author editor and co editor of a number of publications and a recipient of several awards and fellowships Medical societies of which he has been president include the International Association for Dental Research British Society for Oral and Dental Research European Association of Oral Medicine and the Hunterian Society and the world s oldest rugby club Guy s Hospital RFC Contents 1 Early life 2 Mucosal immunology 3 Later career 3 1 Challacombe scale 3 2 Global oral health 3 3 History of medicine 4 Awards and honours 4 1 Awards 4 2 Presidencies 4 3 Chairmanships 4 4 Fellowships 5 Personal life 6 Writing 6 1 Selected publications 6 1 1 Articles 6 1 2 Books 7 References 8 Further readingEarly life editStephen Challacombe was born in April 1946 He attended Culford School where he played sports including rugby 1 Mucosal immunology editHe initially worked in the field of immunology 2 In 1978 he was appointed assistant professor and senior research fellow in the Department of Immunology at the Mayo Clinic in the United States 3 and completed the fellowship in 1979 4 From 1984 to 2011 he was consultant in diagnostic microbiology and immunology to Guys amp St Thomas Hospitals 5 During this time he became professor of oral medicine in the department of Oral Medicine and Pathology at Guy s Hospital in 1986 and the Martin Rushton Professor of oral medicine in 1988 2 6 Later career editChallacombe was appointed Director of External Strategy at the Dental Institute in 2005 and a year later became Dean for King s College London KCL External Affairs holding both posts until 2011 5 7 His experience has also included coordinating conferences and university departments managing grants finances and research and teaching 3 Challacombe scale edit He developed the Challacombe scale for measuring the extent of dryness of the mouth in human beings It was launched in 2011 at Tylney Hall in Hampshire 8 and has become widely used as a medical tool for assessing and monitoring dry mouth 9 10 11 Global oral health edit Challacombe became involved in clinical research in oral HIV and AIDS and has chaired international workshops on the oral manifestations of HIV infection in the UK South Africa Thailand China and India In 1991 and 1993 he contributed to the consensus meeting on the classification of oral lesions in HIV 1 3 He was chairman of the International Steering Committee on Oral Health and Disease in HIV infection between 2000 and 2017 3 In 2011 he led the team that laid out research challenges of global health inequalities and oral health particularly relating to Noma tuberculosis sexually transmitted disease and HIV four of the most serious global oral health infections 12 13 14 With regards to clinical signs in the mouth in AIDS he identified a significant role for dentists 13 Later using Sierra Leone as a case study to develop oral health programmes in low income countries he worked with the King s Sierra Leone Partnership s dentistry section 15 as a member of The Kings Centre for Global Health 1 In 2020 he co authored a review which proposed using povidone iodine to reduce cross infectivity of COVID 19 16 and highlighted the role of saliva in the transmission of the disease 17 History of medicine edit As a historian of medicine his lectures have included a series on the London medical students at Belsen 18 Awards and honours editAwards edit Challacombe is a recipient of a number of awards including Colgate Hatton Research Prize British Division IADR 1977 5 Kendall Hench Research Fellowship Mayo Clinic Minnesota USA 1978 5 Basic Research in Oral Science Award IADR 1981 5 Distinguished Scientist Award for Experimental Pathology IADR 1997 5 DSc h c University of Athens 2012 5 American Academy of Oral Medicine Samuel Charles Miller award 2018 5 19 Distinguished Alumni Award of the Mayo Clinic 2017 4 Presidencies edit nbsp Stephen Challacombe Hunterian Society October 2019 He has been president of International Association for Dental Research IADR 2003 5 British Society for Oral and Dental Research 2000 02 5 British Society for Oral Medicine 1996 98 5 Odontological section of Royal Society of Medicine 1997 98 5 British Dental Association BDA Metropolitan Branch 2000 01 5 European Association of Oral Medicine 2008 10 5 Hunterian Society 2006 7 2018 19 5 History of Medicine Society 2019 20 5 He has also been president of the world s oldest rugby club Guy s Hospital RFC 1 20 Chairmanships edit He was chairman of International steering committee on Oral Health amp Disease in AIDS 2000 17 5 Mucosal immunology group of the British Society for Immunology 1987 1992 5 NIDCR OHARA External Experts Advisory panel 2007 2013 5 Fellowships edit He is a fellow of the Royal College of Pathologists 5 Royal College of Surgeons of Edinburgh 5 Academy of Medical Sciences United Kingdom 1998 5 King s College London 2010 21 Royal College of Surgeons of England 6 Personal life editHe is married to Tina and they have two children 1 In 2013 he joined the Board of Governors of Culford School 1 He also continues to support students of the world s oldest rugby club Guy s Hospital RFC 22 Writing editHe has been an author co author editor and co editor of a number of publications including nine books over 240 peer reviewed research papers and 160 other works on various aspects of oral and maxillofacial medicine 3 These have included publications on induction of secretory immune responses oral tolerance and on immunological aspects of the oral cavity 2 His interest on mucosal immunity in HIV and how HIV can present with signs in the mouth has resulted in over 25 research articles 3 Selected publications edit Articles edit Challacombe S J Tomasi T B 1 December 1980 Systemic tolerance and secretory immunity after oral immunization Journal of Experimental Medicine 152 6 Rockefeller University Press 1459 1472 doi 10 1084 jem 152 6 1459 ISSN 0022 1007 PMC 2186016 PMID 7452148 S2CID 17098839 Salivary Antibodies and Systemic Tolerance in Mice after Oral Immunization with Bacterial Antigens Annals of the New York Academy of Sciences June 1983 doi 10 1111 j 1749 6632 1983 tb26868 x Oral mucosal lesions what the general practitioner needs to know Wynnum Qld 2009 DVD ROM Beijing Declaration 2009 Advances in Dental Research 25 March 2011 doi 10 1177 0022034511399085 Clinical assessment of oral dryness development of a scoring system related to salivary flow and mucosal wetness Oral Surgery Oral Medicine Oral Pathology and Oral Radiology November 2012 Volume 114 Issue 5 Pages 597 603 doi 10 1016 j oooo 2012 05 009 With S M Osailan R Pramanik B P Shirlawb G B Proctor The mouth and AIDS lessons learned and emerging challenges in global oral health introduction Oral Diseases 2016 22 Suppl 1 5 6 doi 10 1111 odi 12426 With AR Tappuni and K Ranganathan Global oral inequalities in HIV infection Oral Diseases 2016 22 Suppl 1 pp 35 41 doi 10 1111 odi 12408 Dry Mouth and Clinical Oral Dryness Scoring Systems Primary Dental Journal 2016 Feb 1 5 1 77 79 PMID 29029657 With P Das Fortitude and resilience in service of the population a case study of dental professionals striving for health in Sierra Leone British Dental Journal Open 2019 5 7 Published online 2019 May 13 doi 10 1038 s41405 019 0011 2 Books edit Advances in Mucosal Immunology Proceedings of the Fifth International Congress of Mucosal Immunology co authored with Thomas T MacDonald Paul W Bland Christopher R Stokes Richard V Heatley Allan Mcl Mowat Dordrecht Springer Netherlands 1990 ISBN 9789400918481 OCLC 840304723 Food allergy co authored with Jonathan Brostoff Saunders 1998 Clinics in immunology and allergy v 2 no 1 OCLC 9254958 Food Allergy and Intolerance co authored with Jonathan Brostoff Saunders 2002 ISBN 9780702020384 Oral and Maxillofacial Medicine The Basis of Diagnosis and Treatment Churchill LivingstoneReferences edit a b c d e f Culford School Meet the Governors www culford co uk Retrieved 23 May 2020 a b c Challacombe S Bland P Stokes C Heatley A Mowat A 1990 Advances in Mucosal Immunology Proceedings of the Fifth International Congress of Mucosal Immunology Springer Science amp Business Media ISBN 0 7462 0113 3 a b c d e f World Workshop Global Overview of HIV ww8aids org Faculty of Dentistry Universitas Padjadjaran 2018 Retrieved 26 June 2019 a b Mayo Clinic announces 2017 Distinguished Alumni Awards newsnetwork mayoclinic org Retrieved 26 June 2019 a b c d e f g h i j k l m n o p q r s t u v Professor Stephen Challacombe www kcl ac uk Retrieved 25 June 2019 a b Stephen Challacombe Linked in Retrieved 30 July 2019 In Touch Autumn 2013 Issuu Retrieved 11 July 2019 Dry mouth scale launched British Dental Journal 211 8 351 21 October 2011 doi 10 1038 sj bdj 2011 884 ISSN 1476 5373 Meurman Jukka H 2018 Translational Oral Health Research Springer p 15 ISBN 978 3 319 78204 1 Katz James D Walitt Brian 2018 Rheumatic Diseases in Older Adults An Issue of Rheumatic Disease Clinics of North America E Book Elsevier Health Sciences p 426 ISBN 9780323613545 Banerjee Avijit Watson Timothy F 2015 Pickard s Guide to Minimally Invasive Operative Dentistry Oxford University Press ISBN 9780198712091 Challacombe S Chidzonga M Glick M Hodgson T Magalhaes M Shiboski C Owotade F Ranganathan R Naidoo S May 2011 Williams D M ed Global Oral Health Inequalities Oral Infections Challenges and Approaches Advances in Dental Research 23 2 227 236 doi 10 1177 0022034511402081 ISSN 0895 9374 PMID 21490235 S2CID 5256917 a b Wilson Nairn Dunne Stephen 2018 Manual of Clinical Procedures in Dentistry John Wiley amp Sons p 30 ISBN 9780470670521 Tappuni A R Shiboski C 2016 Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS PDF Oral Diseases 22 S1 211 214 doi 10 1111 odi 12459 ISSN 1601 0825 PMID 27109289 Dentistry King s Sierra Leone Partnership Retrieved 11 July 2019 Vlessides Michael 12 June 2020 Can Mouthwash Douse the Spread of COVID 19 Medscape Retrieved 5 July 2020 Joint international virtual seminar Saliva as an important body fluid in the COVID 19 pandemic www kcl ac uk Retrieved 3 October 2020 Burns Judith 15 April 2020 The medical students who saved lives at Belsen BBC News Retrieved 23 May 2020 History of Awards Samuel Charles Miller www aaom com Retrieved 26 June 2019 Guys Rugby 9 April 2009 Archived from the original on 9 April 2009 Retrieved 10 July 2019 Fellowship for Professor Challacombe British Dental Journal 209 5 202 11 September 2010 doi 10 1038 sj bdj 2010 782 ISSN 1476 5373 S2CID 33400233 King s College London Association KCLA Sports Dinner www kcla co uk Retrieved 26 June 2019 Further reading edit The Medical Research Council s Review of the Future of the National Institute for Medical Research Fourth Report of Session 2004 05 Volume II Oral and written evidence Retrieved from https en wikipedia org w index php title Stephen J Challacombe amp oldid 1203795059, wikipedia, wiki, book, books, library,

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