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Soricidin

April 20, 2024

Soricidin is a paralytic oligopeptide found in the venomous saliva of the northern short-tailed shrew (Blarina brevicauda);[1] in the wild, shrews use it to paralyze their prey (typically insects).[2] Its name is a reference to "Soricidae", the family to which shrews belong.[3]

In addition to blocking transmission of nerve impulses[4] by inhibiting sodium channels, soricidin also inhibits the TRPV6 calcium channel,[5] which is over-expressed in many epithelial-cell cancers; as a result, soricidin is able to selectively induce apoptosis[6] in breast, ovarian, and prostate cancer.[7]

It is 54 amino acids long.[1] It was first extracted and identified in 2000, as a result of basic research[3] by Jack Stewart of Mount Allison University.[8]

References edit

  1. ^ a b Soricidin - Blarina brevicauda (Northern short-tailed shrew) at UniProt; version 15; published October 31, 2012; retrieved December 13, 2013
  2. ^ Venom of the Short-Tailed Shrew (Blarina brevicauda) as an Insect Immobilizing Agent, by Irwin G. Martin, in the Journal of Mammalogy (archived at JSTOR); Vol. 62, No. 1 (Feb., 1981), pp. 189-192
  3. ^ a b The Stunning Saliva Of Shrews: Researchers are trying to unravel the mystery of the shrew's venomous brew, by Rachel Sheremeta Pepling; in Chemical & Engineering News; published October 13, 2004; retrieved December 13, 2013
  4. ^ Shrew spit tames cancer cells at CBC.ca; published May 24, 2010; retrieved December 13, 2013
  5. ^ In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin, by Chris V. Bowen, Drew DeBay, H. Stephen Ewart, Pamela Gallant, Sean Gormley, T. Toney Ilenchuk, Umar Iqbal, Tyler Lutes, Marzia Martina, Geoffrey Mealing, Nadine Merkley, Sandra Sperker, Maria J. Moreno, Christopher Rice, Raymond T. Syvitski, and John M. Stewart; in PLoS One; published: March 15, 2013; retrieved December 13, 2013; DOI: 10.1371/journal.pone.0058866
  6. ^ The Seventh Annual Ion Channel Retreat - Vancouver, Canada, June 29 – July 1, 2009 - MEETING REPORT, by Saranna Brugger, Susannah Kennedy, and Noel King; in ASSAY and Drug Development Technologies; vol. 8, no. 1, February 2010; doi: 0.1089/adt.2009.0241
  7. ^ Quest for a wonder drug started with shrew bait, by Dakshana Bascaramurty; at The Globe and Mail; published August 8, 2012; retrieved December 13, 2013
  8. ^ Open up and say 'aah', by Tom Henheffer; at Maclean's; published July 1, 2010; retrieved December 13, 2013

April 20, 2024
soricidin, paralytic, oligopeptide, found, venomous, saliva, northern, short, tailed, shrew, blarina, brevicauda, wild, shrews, paralyze, their, prey, typically, insects, name, reference, soricidae, family, which, shrews, belong, addition, blocking, transmissi. Soricidin is a paralytic oligopeptide found in the venomous saliva of the northern short tailed shrew Blarina brevicauda 1 in the wild shrews use it to paralyze their prey typically insects 2 Its name is a reference to Soricidae the family to which shrews belong 3 In addition to blocking transmission of nerve impulses 4 by inhibiting sodium channels soricidin also inhibits the TRPV6 calcium channel 5 which is over expressed in many epithelial cell cancers as a result soricidin is able to selectively induce apoptosis 6 in breast ovarian and prostate cancer 7 It is 54 amino acids long 1 It was first extracted and identified in 2000 as a result of basic research 3 by Jack Stewart of Mount Allison University 8 References edit a b Soricidin Blarina brevicauda Northern short tailed shrew at UniProt version 15 published October 31 2012 retrieved December 13 2013 Venom of the Short Tailed Shrew Blarina brevicauda as an Insect Immobilizing Agent by Irwin G Martin in the Journal of Mammalogy archived at JSTOR Vol 62 No 1 Feb 1981 pp 189 192 a b The Stunning Saliva Of Shrews Researchers are trying to unravel the mystery of the shrew s venomous brew by Rachel Sheremeta Pepling in Chemical amp Engineering News published October 13 2004 retrieved December 13 2013 Shrew spit tames cancer cells at CBC ca published May 24 2010 retrieved December 13 2013 In Vivo Detection of Human TRPV6 Rich Tumors with Anti Cancer Peptides Derived from Soricidin by Chris V Bowen Drew DeBay H Stephen Ewart Pamela Gallant Sean Gormley T Toney Ilenchuk Umar Iqbal Tyler Lutes Marzia Martina Geoffrey Mealing Nadine Merkley Sandra Sperker Maria J Moreno Christopher Rice Raymond T Syvitski and John M Stewart in PLoS One published March 15 2013 retrieved December 13 2013 DOI 10 1371 journal pone 0058866 The Seventh Annual Ion Channel Retreat Vancouver Canada June 29 July 1 2009 MEETING REPORT by Saranna Brugger Susannah Kennedy and Noel King in ASSAY and Drug Development Technologies vol 8 no 1 February 2010 doi 0 1089 adt 2009 0241 Quest for a wonder drug started with shrew bait by Dakshana Bascaramurty at The Globe and Mail published August 8 2012 retrieved December 13 2013 Open up and say aah by Tom Henheffer at Maclean s published July 1 2010 retrieved December 13 2013 Retrieved from https en wikipedia org w index php title Soricidin amp oldid 1004635142, wikipedia, wiki, book, books, library,

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