The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene.[5]
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.[6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus.[7] Most of the remaining glucose absorption is by sodium/glucose cotransporter 1 (SGLT1) in more distal sections of the proximal tubule.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000140675 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030781 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wells RG, Mohandas TK, Hediger MA (Sep 1993). "Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere". Genomics. 17 (3): 787–9. doi:10.1006/geno.1993.1411. PMID 8244402.
^"Entrez Gene: solute carrier family 5 (sodium/glucose cotransporter)".
^Vallon V, Thomson SC (2012). "Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney". Annual Review of Physiology. 74: 351–375. doi:10.1146/annurev-physiol-020911-153333. PMC3807782. PMID 22335797.
^Haas B, Eckstein N, Pfeifer V, Mayer P, Hass MD (2014). "Efficacy, safety and regulatory status of SGLT2 inhibitors: focus on canagliflozin". Nutrition & Diabetes. 4 (11): e143. doi:10.1038/nutd.2014.40. PMC4259905. PMID 25365416.
^Rawla, P; Vellipuram, AR; Bandaru, SS; Pradeep Raj, J (2017). "Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma". Endocrinology, Diabetes & Metabolism Case Reports. 2017. doi:10.1530/EDM-17-0081. PMC5592704. PMID 28924481.
^"FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood". Food and Drug Administration, USA. 2015-05-15.
^"SGLT2 Inhibitors Associated with Fournier Gangrene". Jwatch.org. Retrieved 2019-05-06.
van den Heuvel LP, Assink K, Willemsen M, Monnens L (Dec 2002). "Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)". Human Genetics. 111 (6): 544–7. doi:10.1007/s00439-002-0820-5. PMID 12436245. S2CID 28089635.
Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, Brodehl J, Daschner M, Ehrich JH, Kemper M, Li Volti S, Neuhaus T, Skovby F, Swift PG, Schaub J, Klaerke D (Nov 2003). "Molecular analysis of the SGLT2 gene in patients with renal glucosuria". Journal of the American Society of Nephrology. 14 (11): 2873–82. doi:10.1097/01.asn.0000092790.89332.d2. PMID 14569097.
Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA (Sep 1992). "Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter". The American Journal of Physiology. 263 (3 Pt 2): F459-65. doi:10.1152/ajprenal.1992.263.3.F459. PMID 1415574.
Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A, Scharf M, Tasic V, Greil J, Brinkert F, Kemper MJ, Santer R (Dec 2008). "Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion". Nephrology, Dialysis, Transplantation. 23 (12): 3874–9. doi:10.1093/ndt/gfn386. PMID 18622023.
Calado J, Soto K, Clemente C, Correia P, Rueff J (Feb 2004). "Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria". Human Genetics. 114 (3): 314–6. doi:10.1007/s00439-003-1054-x. PMID 14614622. S2CID 23741937.
Magen D, Sprecher E, Zelikovic I, Skorecki K (Jan 2005). "A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria". Kidney International. 67 (1): 34–41. doi:10.1111/j.1523-1755.2005.00053.x. PMID 15610225.
Castaneda F, Burse A, Boland W, Kinne RK (2007). "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes". International Journal of Medical Sciences. 4 (3): 131–9. doi:10.7150/ijms.4.131. PMC1868657. PMID 17505558.
May 02, 2024
sodium, glucose, cotransporter, sodium, glucose, cotransporter, sglt2, protein, that, humans, encoded, slc5a2, solute, carrier, family, sodium, glucose, cotransporter, gene, slc5a2available, structurespdbortholog, search, pdbe, rcsblist, codes7vsi, 7ynk, 7ynji. The sodium glucose cotransporter 2 SGLT2 is a protein that in humans is encoded by the SLC5A2 solute carrier family 5 sodium glucose cotransporter gene 5 SLC5A2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes7VSI 7YNK 7YNJIdentifiersAliasesSLC5A2 SGLT2 solute carrier family 5 member 2External IDsOMIM 182381 MGI 2181411 HomoloGene 2289 GeneCards SLC5A2Gene location Human Chr Chromosome 16 human 1 Band16p11 2Start31 483 002 bp 1 End31 490 860 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 F3Start127 864 829 bp 2 End127 871 602 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inkidney tubulekidneyglomerulusmetanephric glomerulusbone marrow cellsstriated muscle tissueskeletal muscle tissuestromal cell of endometriumrenal medullathymusTop expressed inkidneymolarmucous cell of stomachsupraoptic nucleusventromedial nucleuscrypt of lieberkuhn of small intestineprimary motor cortexglobus pallidusmasseter musclelateral hypothalamusMore reference expression dataBioGPSn aGene ontologyMolecular functionlow affinity glucose sodium symporter activity symporter activity transporter activity glucose sodium symporter activity transmembrane transporter activityCellular componentintegral component of membrane plasma membrane extracellular exosome membrane integral component of plasma membraneBiological processcarbohydrate transport ion transport glucose transmembrane transport sodium ion transport transmembrane transport hexose transmembrane transport transport carbohydrate metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6524246787EnsemblENSG00000140675ENSMUSG00000030781UniProtP31639Q923I7RefSeq mRNA NM 003041NM 133254RefSeq protein NP 003032NP 573517Location UCSC Chr 16 31 48 31 49 MbChr 7 127 86 127 87 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 SGLT2 inhibitors for diabetes 3 Clinical significance 4 See also 5 References 6 Further readingFunction editSGLT2 is a member of the sodium glucose cotransporter family which are sodium dependent glucose transport proteins SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney 6 SGLT2 is located in the early proximal tubule and is responsible for reabsorption of 80 90 of the glucose filtered by the kidney glomerulus 7 Most of the remaining glucose absorption is by sodium glucose cotransporter 1 SGLT1 in more distal sections of the proximal tubule 8 SGLT2 inhibitors for diabetes editMain article SGLT2 inhibitor SGLT2 inhibitors are also called gliflozins or flozins They lead to a reduction in blood glucose levels and therefore have potential use in the treatment of type 2 diabetes Gliflozins enhance glycemic control as well as reduce body weight and systolic and diastolic blood pressure 9 The gliflozins canagliflozin dapagliflozin and empagliflozin may lead to euglycemic ketoacidosis 10 11 Other side effects of gliflozins include increased risk of Fournier gangrene 12 and of generally mild genital infections such as candidal vulvovaginitis 13 Clinical significance editMutations in this gene are also associated with renal glycosuria 14 See also editSGLT Family Discovery and development of gliflozins Phlorizin a competitive inhibitor of SGLT1 and SGLT2References edit a b c GRCh38 Ensembl release 89 ENSG00000140675 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030781 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wells RG Mohandas TK Hediger MA Sep 1993 Localization of the Na glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere Genomics 17 3 787 9 doi 10 1006 geno 1993 1411 PMID 8244402 Entrez Gene solute carrier family 5 sodium glucose cotransporter Bonora BM Avogaro A Fadini GP 2020 Extraglycemic Effects of SGLT2 Inhibitors A Review of the Evidence Diabetes Metabolic Syndrome and Obesity Targets and Therapy 13 161 174 doi 10 2147 DMSO S233538 PMC 6982447 PMID 32021362 Vallon V Thomson SC 2012 Renal function in diabetic disease models the tubular system in the pathophysiology of the diabetic kidney Annual Review of Physiology 74 351 375 doi 10 1146 annurev physiol 020911 153333 PMC 3807782 PMID 22335797 Haas B Eckstein N Pfeifer V Mayer P Hass MD 2014 Efficacy safety and regulatory status of SGLT2 inhibitors focus on canagliflozin Nutrition amp Diabetes 4 11 e143 doi 10 1038 nutd 2014 40 PMC 4259905 PMID 25365416 Rawla P Vellipuram AR Bandaru SS Pradeep Raj J 2017 Euglycemic diabetic ketoacidosis a diagnostic and therapeutic dilemma Endocrinology Diabetes amp Metabolism Case Reports 2017 doi 10 1530 EDM 17 0081 PMC 5592704 PMID 28924481 FDA Drug Safety Communication FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood Food and Drug Administration USA 2015 05 15 SGLT2 Inhibitors Associated with Fournier Gangrene Jwatch org Retrieved 2019 05 06 SGLT2 Inhibitors Gliflozins Diabetes co uk Retrieved 2015 05 19 Calado J Loeffler J Sakallioglu O Gok F Lhotta K Barata J Rueff J Mar 2006 Familial renal glucosuria SLC5A2 mutation analysis and evidence of salt wasting Kidney International 69 5 852 5 doi 10 1038 sj ki 5000194 PMID 16518345 Further reading editvan den Heuvel LP Assink K Willemsen M Monnens L Dec 2002 Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter SGLT2 Human Genetics 111 6 544 7 doi 10 1007 s00439 002 0820 5 PMID 12436245 S2CID 28089635 Santer R Kinner M Lassen CL Schneppenheim R Eggert P Bald M Brodehl J Daschner M Ehrich JH Kemper M Li Volti S Neuhaus T Skovby F Swift PG Schaub J Klaerke D Nov 2003 Molecular analysis of the SGLT2 gene in patients with renal glucosuria Journal of the American Society of Nephrology 14 11 2873 82 doi 10 1097 01 asn 0000092790 89332 d2 PMID 14569097 Wells RG Pajor AM Kanai Y Turk E Wright EM Hediger MA Sep 1992 Cloning of a human kidney cDNA with similarity to the sodium glucose cotransporter The American Journal of Physiology 263 3 Pt 2 F459 65 doi 10 1152 ajprenal 1992 263 3 F459 PMID 1415574 Calado J Sznajer Y Metzger D Rita A Hogan MC Kattamis A Scharf M Tasic V Greil J Brinkert F Kemper MJ Santer R Dec 2008 Twenty one additional cases of familial renal glucosuria absence of genetic heterogeneity high prevalence of private mutations and further evidence of volume depletion Nephrology Dialysis Transplantation 23 12 3874 9 doi 10 1093 ndt gfn386 PMID 18622023 Calado J Soto K Clemente C Correia P Rueff J Feb 2004 Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria Human Genetics 114 3 314 6 doi 10 1007 s00439 003 1054 x PMID 14614622 S2CID 23741937 Magen D Sprecher E Zelikovic I Skorecki K Jan 2005 A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal recessive renal glucosuria and aminoaciduria Kidney International 67 1 34 41 doi 10 1111 j 1523 1755 2005 00053 x PMID 15610225 Castaneda F Burse A Boland W Kinne RK 2007 Thioglycosides as inhibitors of hSGLT1 and hSGLT2 potential therapeutic agents for the control of hyperglycemia in diabetes International Journal of Medical Sciences 4 3 131 9 doi 10 7150 ijms 4 131 PMC 1868657 PMID 17505558 Retrieved from https en wikipedia org w index php title Sodium glucose cotransporter 2 amp oldid 1217623792, wikipedia, wiki, book, books, library,
