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Smallpox virus retention debate

January 01, 1970

The smallpox virus retention debate has been going on among scientists and health officials since the smallpox virus was declared eradicated by the World Health Organization (WHO) in 1980.[1][2] The debate centers on whether or not the last two known remnants of the Variola virus known to cause smallpox, which are kept in tightly controlled government laboratories in the United States and Russia, should be finally and irreversibly destroyed. Advocates of final destruction maintain that there is no longer any valid rationale for retaining the samples, which pose the hazard of escaping the laboratories, while opponents of destruction maintain that the samples may still be of value to scientific research, especially since variants of the smallpox virus may still exist in the natural world and thus present the possibility of the disease re-emerging in the future or being used as a bio-weapon.

Background edit

In 1981, the four countries that either served as a WHO collaborating center or were actively working with variola virus were the United States, the United Kingdom, the Soviet Union, and South Africa. The last cases of smallpox occurred in an outbreak of two cases, one of which was fatal, in Birmingham, United Kingdom, in 1978. A medical photographer, Janet Parker, contracted the disease at the University of Birmingham Medical School and died on September 11, 1978.[3] In light of this incident, all known stocks of the smallpox virus were destroyed or transferred to one of two World Health Organization reference laboratories which had BSL-4 facilities—the Centers for Disease Control and Prevention (CDC) in the United States and the State Research Center of Virology and Biotechnology VECTOR in Koltsovo, Soviet Union.[4] Since 1984, these two labs have been the only ones authorized by the WHO to hold stocks of live smallpox virus.[citation needed]

In 1986, the WHO first recommended destruction of all smallpox samples, and later set the date of destruction to be 30 December 1993. This was postponed to 30 June 1999,[5] then again to 30 June 2002. Due to resistance from the U.S. and Russia, in 2002 the World Health Assembly agreed to permit temporary retention of the virus stocks for specific research purposes.[6] Destroying existing stocks would reduce the risk involved with ongoing smallpox research; the stocks are not needed to respond to a smallpox outbreak.[7] Some scientists have argued that the stocks may be useful in developing new vaccines, antiviral drugs, and diagnostic tests.[8] A 2010 review by a team of public health experts appointed by the WHO, however, concluded that no essential public health purpose is served by the American and Russian laboratories continuing to retain live virus stocks.[9] The latter view is frequently supported in the scientific community, particularly among veterans of the WHO Smallpox Eradication Program (1958–1979).[10]

History edit

Ad Hoc Committee on Orthopox Infections edit

An Ad Hoc Committee on Orthopox Infections, advising the WHO, has debated the fate of the remaining samples of smallpox in the remaining two official repositories since 1980. Smallpox expert D. A. Henderson has been foremost in favor of destruction, while U.S. Army scientist Peter Jahrling has argued against it on the basis that further research is needed, since he believes that smallpox almost certainly exists outside of the repositories.[11] Other scientists have expressed similar opinions.[12]

U.S. pro-retention argument (2011) edit

In 2011, Kathleen Sebelius, Secretary of the U.S. Department of Health and Human Services, laid out the rationale of the administration of President Barack Obama in a New York Times op-ed piece. She said, in part:

The global public health community assumes that all nations acted in good faith; however, no one has ever attempted to verify or validate compliance with the WHO request.... Although keeping the samples may carry a minuscule risk, both the United States and Russia believe the dangers of destroying them now are far greater.... It is quite possible that undisclosed or forgotten stocks exist. Also, 30 years after the disease was eradicated, the virus' genomic information is available online and the technology now exists for someone with the right tools and the wrong intentions to create a new smallpox virus in a laboratory.... Destroying the virus now is merely a symbolic act that would slow our progress and could even stop it completely, leaving the world vulnerable.... Destruction of the last securely stored viruses is an irrevocable action that should occur only when the global community has eliminated the threat of smallpox once and for all. To do any less keeps future generations at risk from the re-emergence of one of the deadliest diseases humanity has ever known. Until this research is complete, we cannot afford to take that risk.[13]

Post-1984 discovery instances edit

  • In 2013, cloned variola major (smallpox) DNA fragments were found in a South African laboratory. The WHO arranged to oversee their destruction, which took place in January 2014.[14][15]
  • On July 1, 2014, the U.S. National Institutes of Health (NIH) notified the regulatory agency, the Division of Select Agents and Toxins (DSAT) of the CDC, that employees had discovered vials labeled "variola" in an unused portion of a storage room in a U.S. Food and Drug Administration (FDA) laboratory located on the NIH Bethesda campus.[16] In a media statement made seven days later, the CDC confirmed that variola major had been found and it had been transferred to a BSL-4 laboratory at the CDC in Atlanta. Overnight PCR testing had shown the vials did contain variola major. The vials were believed to have been from the 1950s.[16] Further testing showed that the vials contained viable (live) variola major virus. As of the end of 2014, the vials were placed in a secure freezer to await destruction. The protocol for destruction of variola major virus involves a member of the WHO being present at the destruction. Usually the observer watches via closed-circuit television outside the room where the variola virus is autoclaved to destroy it. As a result of the Ebola outbreak in parts of Africa around the same time, the WHO were overstretched and stated they had no one locally with sufficient security clearance to enter a BSL-4 laboratory. Due to this the WHO were planning to fly an official into Atlanta to oversee the destruction at a future date.[15] The vials were finally destroyed on February 24, 2015, under the supervision of WHO officials.[17]

WHO 2018 position edit

As of May 2018, based on the latest (19th) meeting of the WHO Advisory Committee on Variola Virus Research (1–2 November 2017), the question remained as to whether the use of live variola virus for their further development was "essential for public health."[18]

2019 lab explosion edit

In September 2019, the Russian lab housing smallpox samples experienced a gas explosion that injured one worker. It did not occur near the virus storage area, and no samples were compromised, but the incident prompted a review of risks to containment.[19]

2021 Pennsylvania discovery edit

In November 2021 the CDC announced that several frozen vials labeled "Smallpox" were discovered in a freezer in a Merck & Co. vaccine research facility at Montgomery County, Pennsylvania.[20][21][22] The vials were determined to contain the vaccinia virus, used in making the vaccine, not the variola virus, which causes smallpox.[23]

References edit

  1. ^ . WHO Factsheet. Archived from the original on 21 September 2007.
  2. ^ Fenner F (2006). Nature, Nurture and Chance: The Lives of Frank and Charles Fenner. Canberra, ACT 0200: Australian National University Press. ISBN 978-1-920942-62-5.{{cite book}}: CS1 maint: location (link)
  3. ^ Pennington, Hugh (2003). "Smallpox and bioterrorism" (PDF). Bull. World Health Organ. 81 (10): 762–767. PMC 2572332. PMID 14758439.
  4. ^ Connor, Steve (2002-01-03). . The Independent. London. Archived from the original on February 11, 2009. Retrieved 2008-10-03.
  5. ^ Altman, Lawrence (1996-01-25). "Final Stock of the Smallpox Virus Now Nearer to Extinction in Labs". The New York Times. Retrieved 2007-11-23.
  6. ^ MacKenzie, Debora (2002-01-26). "Stay of execution". New Scientist. Retrieved 2007-11-23.
  7. ^ Hammond, Edward (2007). "Should the US and Russia destroy their stocks of smallpox virus?". BMJ. 334 (7597): 774. doi:10.1136/bmj.39155.695255.94. PMC 1851992. PMID 17431261.
  8. ^ Agwunobi, John O. (2007). "Should the US and Russia destroy their stocks of smallpox virus?". BMJ. 334 (7597): 775. doi:10.1136/bmj.39156.490799.BE. PMC 1851995. PMID 17431262.
  9. ^ Comments on the Scientific Review of Variola Virus Research, 1999‐2010. Advisory Group of Independent Experts to review the smallpox research program (AGIES) WHO document WHO/HSE/GAR/BDP/2010.4
  10. ^ Lane, J.Michael; Poland, Gregory A. (2011). "Why not destroy the remaining smallpox virus stocks?". Vaccine. 29 (16): 2823–2824. doi:10.1016/j.vaccine.2011.02.081. PMID 21376120.
  11. ^ Preston, Richard (2002), The Demon in the Freezer.[page needed]
  12. ^ Damon, Inger k; Damaso, Clarissa R; McFadden, Grant (May 1, 2014). "Are we there yet? The smallpox research agenda using variola virus". PLOS Pathogens. 10 (5): e1004108. doi:10.1371/journal.ppat.1004108. PMC 4006926. PMID 24789223.
  13. ^ Sebelius, Kathleen, (2011), "Why We Still need Smallpox", The New York Times (25 April 2011).
  14. ^ "Smallpox eradication: destruction of variola virus stocks Report by the Secretariat" (PDF). World Health Organisation Executive Board EB134/34 134th session. 20 December 2013. 134th session.
  15. ^ a b Reardon, Sara (2014-10-30). "'Forgotten' NIH smallpox virus languishes on death row". Nature. 514 (7524): 544. Bibcode:2014Natur.514..544R. doi:10.1038/514544a. PMID 25355337.
  16. ^ a b Centers for Disease Control and Prevention "CDC Media Statement on Newly Discovered Smallpox Specimens" (July 8, 2014).
  17. ^ "FDA Review of the 2014 Discovery of Vials Labeled "Variola" and Other Vials Discovered in an FDA-Occupied Building on the NIH Campus" (PDF). Director of Laboratory Science and Safety, FDA. 13 December 2016. Retrieved 21 May 2017.
  18. ^ . World Health Organization. May 2018. Archived from the original on May 5, 2018. Retrieved May 31, 2018.
  19. ^ Kritz, Fran (September 19, 2019). "Russian Lab Explosion Raises Question: Should Smallpox Virus Be Kept Or Destroyed?". NPR.
  20. ^ "Vials labeled 'Smallpox' found in Pennsylvania lab freezer". The Associated Press. 2021-11-17. Retrieved 2021-11-18.
  21. ^ Fox, Maggie (17 November 2021). "Vials labeled 'smallpox' found at vaccine research facility in Pennsylvania, CDC says". CNN. Retrieved 2021-11-18.
  22. ^ Fieldstadt, Elisha (17 November 2021). "Vials labeled 'smallpox' found by lab worker cleaning freezer in Pennsylvania". NBC News. Retrieved 18 November 2021.
  23. ^ Maggie Fox (19 November 2021). "Vials marked "smallpox" contained virus used in vaccine, not smallpox virus, CDC finds". CNN. Retrieved 2021-11-19.

External links edit

  • Errol Morris New York Times video op-ed (2016)

January 01, 1970
smallpox, virus, retention, debate, smallpox, virus, retention, debate, been, going, among, scientists, health, officials, since, smallpox, virus, declared, eradicated, world, health, organization, 1980, debate, centers, whether, last, known, remnants, variola. The smallpox virus retention debate has been going on among scientists and health officials since the smallpox virus was declared eradicated by the World Health Organization WHO in 1980 1 2 The debate centers on whether or not the last two known remnants of the Variola virus known to cause smallpox which are kept in tightly controlled government laboratories in the United States and Russia should be finally and irreversibly destroyed Advocates of final destruction maintain that there is no longer any valid rationale for retaining the samples which pose the hazard of escaping the laboratories while opponents of destruction maintain that the samples may still be of value to scientific research especially since variants of the smallpox virus may still exist in the natural world and thus present the possibility of the disease re emerging in the future or being used as a bio weapon Contents 1 Background 2 History 2 1 Ad Hoc Committee on Orthopox Infections 2 2 U S pro retention argument 2011 2 3 Post 1984 discovery instances 2 4 WHO 2018 position 2 5 2019 lab explosion 2 6 2021 Pennsylvania discovery 3 References 4 External linksBackground editIn 1981 the four countries that either served as a WHO collaborating center or were actively working with variola virus were the United States the United Kingdom the Soviet Union and South Africa The last cases of smallpox occurred in an outbreak of two cases one of which was fatal in Birmingham United Kingdom in 1978 A medical photographer Janet Parker contracted the disease at the University of Birmingham Medical School and died on September 11 1978 3 In light of this incident all known stocks of the smallpox virus were destroyed or transferred to one of two World Health Organization reference laboratories which had BSL 4 facilities the Centers for Disease Control and Prevention CDC in the United States and the State Research Center of Virology and Biotechnology VECTOR in Koltsovo Soviet Union 4 Since 1984 these two labs have been the only ones authorized by the WHO to hold stocks of live smallpox virus citation needed In 1986 the WHO first recommended destruction of all smallpox samples and later set the date of destruction to be 30 December 1993 This was postponed to 30 June 1999 5 then again to 30 June 2002 Due to resistance from the U S and Russia in 2002 the World Health Assembly agreed to permit temporary retention of the virus stocks for specific research purposes 6 Destroying existing stocks would reduce the risk involved with ongoing smallpox research the stocks are not needed to respond to a smallpox outbreak 7 Some scientists have argued that the stocks may be useful in developing new vaccines antiviral drugs and diagnostic tests 8 A 2010 review by a team of public health experts appointed by the WHO however concluded that no essential public health purpose is served by the American and Russian laboratories continuing to retain live virus stocks 9 The latter view is frequently supported in the scientific community particularly among veterans of the WHO Smallpox Eradication Program 1958 1979 10 History editAd Hoc Committee on Orthopox Infections edit An Ad Hoc Committee on Orthopox Infections advising the WHO has debated the fate of the remaining samples of smallpox in the remaining two official repositories since 1980 Smallpox expert D A Henderson has been foremost in favor of destruction while U S Army scientist Peter Jahrling has argued against it on the basis that further research is needed since he believes that smallpox almost certainly exists outside of the repositories 11 Other scientists have expressed similar opinions 12 U S pro retention argument 2011 edit In 2011 Kathleen Sebelius Secretary of the U S Department of Health and Human Services laid out the rationale of the administration of President Barack Obama in a New York Times op ed piece She said in part The global public health community assumes that all nations acted in good faith however no one has ever attempted to verify or validate compliance with the WHO request Although keeping the samples may carry a minuscule risk both the United States and Russia believe the dangers of destroying them now are far greater It is quite possible that undisclosed or forgotten stocks exist Also 30 years after the disease was eradicated the virus genomic information is available online and the technology now exists for someone with the right tools and the wrong intentions to create a new smallpox virus in a laboratory Destroying the virus now is merely a symbolic act that would slow our progress and could even stop it completely leaving the world vulnerable Destruction of the last securely stored viruses is an irrevocable action that should occur only when the global community has eliminated the threat of smallpox once and for all To do any less keeps future generations at risk from the re emergence of one of the deadliest diseases humanity has ever known Until this research is complete we cannot afford to take that risk 13 Post 1984 discovery instances edit This list is incomplete you can help by adding missing items July 2014 In 2013 cloned variola major smallpox DNA fragments were found in a South African laboratory The WHO arranged to oversee their destruction which took place in January 2014 14 15 On July 1 2014 the U S National Institutes of Health NIH notified the regulatory agency the Division of Select Agents and Toxins DSAT of the CDC that employees had discovered vials labeled variola in an unused portion of a storage room in a U S Food and Drug Administration FDA laboratory located on the NIH Bethesda campus 16 In a media statement made seven days later the CDC confirmed that variola major had been found and it had been transferred to a BSL 4 laboratory at the CDC in Atlanta Overnight PCR testing had shown the vials did contain variola major The vials were believed to have been from the 1950s 16 Further testing showed that the vials contained viable live variola major virus As of the end of 2014 the vials were placed in a secure freezer to await destruction The protocol for destruction of variola major virus involves a member of the WHO being present at the destruction Usually the observer watches via closed circuit television outside the room where the variola virus is autoclaved to destroy it As a result of the Ebola outbreak in parts of Africa around the same time the WHO were overstretched and stated they had no one locally with sufficient security clearance to enter a BSL 4 laboratory Due to this the WHO were planning to fly an official into Atlanta to oversee the destruction at a future date 15 The vials were finally destroyed on February 24 2015 under the supervision of WHO officials 17 WHO 2018 position edit As of May 2018 based on the latest 19th meeting of the WHO Advisory Committee on Variola Virus Research 1 2 November 2017 the question remained as to whether the use of live variola virus for their further development was essential for public health 18 2019 lab explosion edit In September 2019 the Russian lab housing smallpox samples experienced a gas explosion that injured one worker It did not occur near the virus storage area and no samples were compromised but the incident prompted a review of risks to containment 19 2021 Pennsylvania discovery edit In November 2021 the CDC announced that several frozen vials labeled Smallpox were discovered in a freezer in a Merck amp Co vaccine research facility at Montgomery County Pennsylvania 20 21 22 The vials were determined to contain the vaccinia virus used in making the vaccine not the variola virus which causes smallpox 23 References edit Smallpox WHO Factsheet Archived from the original on 21 September 2007 Fenner F 2006 Nature Nurture and Chance The Lives of Frank and Charles Fenner Canberra ACT 0200 Australian National University Press ISBN 978 1 920942 62 5 a href Template Cite book html title Template Cite book cite book a CS1 maint location link Pennington Hugh 2003 Smallpox and bioterrorism PDF Bull World Health Organ 81 10 762 767 PMC 2572332 PMID 14758439 Connor Steve 2002 01 03 How terrorism prevented smallpox being wiped off the face of the planet for ever The Independent London Archived from the original on February 11 2009 Retrieved 2008 10 03 Altman Lawrence 1996 01 25 Final Stock of the Smallpox Virus Now Nearer to Extinction in Labs The New York Times Retrieved 2007 11 23 MacKenzie Debora 2002 01 26 Stay of execution New Scientist Retrieved 2007 11 23 Hammond Edward 2007 Should the US and Russia destroy their stocks of smallpox virus BMJ 334 7597 774 doi 10 1136 bmj 39155 695255 94 PMC 1851992 PMID 17431261 Agwunobi John O 2007 Should the US and Russia destroy their stocks of smallpox virus BMJ 334 7597 775 doi 10 1136 bmj 39156 490799 BE PMC 1851995 PMID 17431262 Comments on the Scientific Review of Variola Virus Research 1999 2010 Advisory Group of Independent Experts to review the smallpox research program AGIES WHO document WHO HSE GAR BDP 2010 4 Lane J Michael Poland Gregory A 2011 Why not destroy the remaining smallpox virus stocks Vaccine 29 16 2823 2824 doi 10 1016 j vaccine 2011 02 081 PMID 21376120 Preston Richard 2002 The Demon in the Freezer page needed Damon Inger k Damaso Clarissa R McFadden Grant May 1 2014 Are we there yet The smallpox research agenda using variola virus PLOS Pathogens 10 5 e1004108 doi 10 1371 journal ppat 1004108 PMC 4006926 PMID 24789223 Sebelius Kathleen 2011 Why We Still need Smallpox The New York Times 25 April 2011 Smallpox eradication destruction of variola virus stocks Report by the Secretariat PDF World Health Organisation Executive Board EB134 34 134th session 20 December 2013 134th session a b Reardon Sara 2014 10 30 Forgotten NIH smallpox virus languishes on death row Nature 514 7524 544 Bibcode 2014Natur 514 544R doi 10 1038 514544a PMID 25355337 a b Centers for Disease Control and Prevention CDC Media Statement on Newly Discovered Smallpox Specimens July 8 2014 FDA Review of the 2014 Discovery of Vials Labeled Variola and Other Vials Discovered in an FDA Occupied Building on the NIH Campus PDF Director of Laboratory Science and Safety FDA 13 December 2016 Retrieved 21 May 2017 WHO Advisory Committee on Variola Virus Research Report of the Nineteenth Meeting World Health Organization May 2018 Archived from the original on May 5 2018 Retrieved May 31 2018 Kritz Fran September 19 2019 Russian Lab Explosion Raises Question Should Smallpox Virus Be Kept Or Destroyed NPR Vials labeled Smallpox found in Pennsylvania lab freezer The Associated Press 2021 11 17 Retrieved 2021 11 18 Fox Maggie 17 November 2021 Vials labeled smallpox found at vaccine research facility in Pennsylvania CDC says CNN Retrieved 2021 11 18 Fieldstadt Elisha 17 November 2021 Vials labeled smallpox found by lab worker cleaning freezer in Pennsylvania NBC News Retrieved 18 November 2021 Maggie Fox 19 November 2021 Vials marked smallpox contained virus used in vaccine not smallpox virus CDC finds CNN Retrieved 2021 11 19 External links editErrol Morris New York Times video op ed 2016 Retrieved from https en wikipedia org w index php title Smallpox virus retention debate amp oldid 1194568269, wikipedia, wiki, book, books, library,

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