^Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T (June 1991). "ONO-5046, a novel inhibitor of human neutrophil elastase". Biochemical and Biophysical Research Communications. 177 (2): 814–820. doi:10.1016/0006-291X(91)91862-7. PMID 2049103.
^Imokawa S, Mori K, Harada M, Sagisaka S, Sano T, Uchiyama H, et al. (June 2008). "[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]". Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society (in Japanese). 46 (6): 461–465. PMID 18592991.
^US 5017610, Imaki K, Arai Y, Okegawa T, "Derivatives of p-substituted phenyl ester of pivalic acid", issued 21 May 1991, assigned to Ono Pharmaceutical Co Ltd
sivelestat, research, name, 5046, marketed, elaspol, inhibitor, human, neutrophil, elastase, clinical, dataahfs, drugs, cominternational, drug, namesroutes, ofadministrationivatc, codenonelegal, statuslegal, statusus, approved, general, prescription, only, ide. Sivelestat INN research name ONO 5046 marketed as Elaspol is an inhibitor of human neutrophil elastase 1 SivelestatClinical dataAHFS Drugs comInternational Drug NamesRoutes ofadministrationIVATC codeNoneLegal statusLegal statusUS Not approved In general Prescription only IdentifiersIUPAC name N 2 4 2 2 dimethylpropanoyl oxy phenyl sulfonyl amino benzoyl glycineCAS Number127373 66 4 NPubChem CID107706IUPHAR BPS6441ChemSpider96875 YUNIIDWI62G0P59KEGGD03788 YChEMBLChEMBL76688 YCompTox Dashboard EPA DTXSID9048304Chemical and physical dataFormulaC 20H 22N 2O 7SMolar mass434 46 g mol 13D model JSmol Interactive imageSMILES CC C C C O OC1 CC C C C1 S O O NC2 CC CC C2C O NCC O OInChI InChI 1S C20H22N2O7S c1 20 2 3 19 26 29 13 8 10 14 11 9 13 30 27 28 22 16 7 5 4 6 15 16 18 25 21 12 17 23 24 h4 11 22H 12H2 1 3H3 H 21 25 H 23 24 YKey BTGNGJJLZOIYID UHFFFAOYSA N Y N Y what is this verify It is used in the treatment of acute respiratory failure 2 and preliminary studies show it may also improve neuropathic pain 3 Synthesis editSivelestat is synthesised as follows 4 nbsp References edit Kawabata K Suzuki M Sugitani M Imaki K Toda M Miyamoto T June 1991 ONO 5046 a novel inhibitor of human neutrophil elastase Biochemical and Biophysical Research Communications 177 2 814 820 doi 10 1016 0006 291X 91 91862 7 PMID 2049103 Imokawa S Mori K Harada M Sagisaka S Sano T Uchiyama H et al June 2008 Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate Nihon Kokyuki Gakkai Zasshi the Journal of the Japanese Respiratory Society in Japanese 46 6 461 465 PMID 18592991 Weyer AD Stucky CL May 2015 Repurposing a leukocyte elastase inhibitor for neuropathic pain Nature Medicine 21 5 429 430 doi 10 1038 nm 3861 PMID 25951529 S2CID 10240018 US 5017610 Imaki K Arai Y Okegawa T Derivatives of p substituted phenyl ester of pivalic acid issued 21 May 1991 assigned to Ono Pharmaceutical Co Ltd nbsp This drug article relating to the respiratory system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Sivelestat amp oldid 1183110169, wikipedia, wiki, book, books, library,
