This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol.
A highly similar protein in mouse has both ferri reductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000157214 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000015653 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC310991. PMID 10613842.
^Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
^ ab"Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".
Further readingedit
Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC1891335. PMID 17567994.
Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC1785011. PMID 16609065.
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.
Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer. 4: 98. doi:10.1186/1471-2407-4-98. PMC546010. PMID 15623366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID 12429817.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
steap2, metalloreductase, enzyme, that, humans, encoded, gene, identifiersaliases, ipca1, pcanap1, pumpcn, stamp1, stmp, metalloreductaseexternal, idsomim, 605094, 1921301, homologene, 17682, genecards, gene, location, human, chromosome, human, band7q21, 13sta. Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene 5 6 7 STEAP2IdentifiersAliasesSTEAP2 IPCA1 PCANAP1 PUMPCn STAMP1 STMP STEAP2 metalloreductaseExternal IDsOMIM 605094 MGI 1921301 HomoloGene 17682 GeneCards STEAP2Gene location Human Chr Chromosome 7 human 1 Band7q21 13Start90 167 590 bp 1 End90 238 137 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 A1Start5 714 829 bp 2 End5 744 578 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpericardiumAchilles tendonprostateBrodmann area 23middle temporal gyruspancreatic epithelial cellcerebellar vermissuperior frontal gyruspostcentral gyrussynovial jointTop expressed inoocytesecondary oocytekidneyolfactory epitheliumciliary bodyirismedial vestibular nucleuspontine nucleiadrenal glandotolith organMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransporter activity metal ion binding cupric reductase activity ferric chelate reductase NADPH activity oxidoreductase activityCellular componentintegral component of membrane integral component of Golgi membrane cytosol endosome membrane plasma membrane early endosome trans Golgi network transport vesicle endosome membrane integral component of plasma membraneBiological processendocytosis iron ion homeostasis copper ion import ion transport response to hormone regulated exocytosis Golgi to plasma membrane transport iron ion import across cell outer membraneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez26172974051EnsemblENSG00000157214ENSMUSG00000015653UniProtQ8NFT2Q8BWB6RefSeq mRNA NM 001040665NM 001040666NM 001244944NM 001244945NM 001244946NM 152999NM 001103156NM 001103157NM 001285469NM 001285470NM 001285471NM 028734RefSeq protein NP 001035755NP 001035756NP 001231873NP 001231874NP 001231875NP 694544NP 001096626NP 001096627NP 001272398NP 001272399NP 001272400NP 083010Location UCSC Chr 7 90 17 90 24 MbChr 5 5 71 5 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene is a member of the STEAP family and encodes a multi pass membrane protein that localizes to the Golgi complex the plasma membrane and the vesicular tubular structures in the cytosol A highly similar protein in mouse has both ferri reductase and cupric reductase activity and stimulates the cellular uptake of both iron and copper in vitro Increased transcriptional expression of the human gene is associated with prostate cancer progression Alternate transcriptional splice variants encoding different isoforms have been characterized 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000157214 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000015653 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Walker MG Volkmuth W Sprinzak E Hodgson D Klingler T Jan 2000 Prediction of Gene Function by Genome Scale Expression Analysis Prostate Cancer Associated Genes Genome Res 9 12 1198 203 doi 10 1101 gr 9 12 1198 PMC 310991 PMID 10613842 Korkmaz KS Elbi C Korkmaz CG Loda M Hager GL Saatcioglu F Sep 2002 Molecular cloning and characterization of STAMP1 a highly prostate specific six transmembrane protein that is overexpressed in prostate cancer J Biol Chem 277 39 36689 96 doi 10 1074 jbc M202414200 PMID 12095985 a b Entrez Gene STEAP2 six transmembrane epithelial antigen of the prostate 2 Further reading editDenoeud F Kapranov P Ucla C et al 2007 Prominent use of distal 5 transcription start sites and discovery of a large number of additional exons in ENCODE regions Genome Res 17 6 746 59 doi 10 1101 gr 5660607 PMC 1891335 PMID 17567994 Ohgami RS Campagna DR McDonald A Fleming MD 2006 The Steap proteins are metalloreductases Blood 108 4 1388 94 doi 10 1182 blood 2006 02 003681 PMC 1785011 PMID 16609065 Korkmaz CG Korkmaz KS Kurys P et al 2005 Molecular cloning and characterization of STAMP2 an androgen regulated six transmembrane protein that is overexpressed in prostate cancer Oncogene 24 31 4934 45 doi 10 1038 sj onc 1208677 PMID 15897894 Sanchez Pulido L Rojas AM Valencia A et al 2005 ACRATA a novel electron transfer domain associated to apoptosis and cancer BMC Cancer 4 98 doi 10 1186 1471 2407 4 98 PMC 546010 PMID 15623366 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Clark HF Gurney AL Abaya E et al 2003 The Secreted Protein Discovery Initiative SPDI a Large Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins A Bioinformatics Assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Porkka KP Helenius MA Visakorpi T 2002 Cloning and characterization of a novel six transmembrane protein STEAP2 expressed in normal and malignant prostate Lab Invest 82 11 1573 82 doi 10 1097 01 lab 0000038554 26102 c6 PMID 12429817 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title STEAP2 amp oldid 1187749588, wikipedia, wiki, book, books, library,
