Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7Lgene.[5][6][7]
The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.[8]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000100335 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022412 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
^Andersson B; Wentland MA; Ricafrente JY; Liu W; Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^Dikov, D.; Reichert, A. S. (2011). "How to split up: Lessons from mitochondria". The EMBO Journal. 30 (14): 2751–2753. doi:10.1038/emboj.2011.219. PMC3160261. PMID 21772324.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Hartley JL; Temple GF; Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC1347501. PMID 16381901.
This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.
smcr7l, mitochondrial, dynamic, protein, mid51, mid51, also, known, mitochondrial, elongation, factor, mief1, smith, magenis, syndrome, chromosome, region, candidate, gene, protein, like, protein, that, humans, encoded, gene, mief1available, structurespdbortho. Mitochondrial dynamic protein MID51 MID51 also known as mitochondrial elongation factor 1 MIEF1 or Smith Magenis syndrome chromosome region candidate gene 7 protein like SMCR7L is a protein that in humans is encoded by the SMCR7L gene 5 6 7 MIEF1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4NXT 4NXU 4NXV 4NXW 4NXXIdentifiersAliasesMIEF1 HSU79252 MID51 SMCR7L dJ1104E15 3 mitochondrial elongation factor 1 AltMIEF1 MPExternal IDsOMIM 615497 MGI 2146020 HomoloGene 10374 GeneCards MIEF1Gene location Human Chr Chromosome 22 human 1 Band22q13 1Start39 499 432 bp 1 End39 518 132 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 E1Start80 118 219 bp 2 End80 137 572 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed intesticlecerebellumcecuminferior ganglion of vagus nervenucleus accumbensstomachcerebellar hemisphereTop expressed inspermatocytespermatidhandsuperior cervical ganglionneural tubelacrimal glandinterventricular septumyolk sacfootendocardial cushionMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding ADP binding protein binding GDP binding identical protein bindingCellular componentintegral component of membrane mitochondrial outer membrane peroxisome membrane mitochondrion mitochondrial matrix mitochondrial large ribosomal subunitBiological processmitochondrial fusion positive regulation of mitochondrial fission mitochondrial fission positive regulation of protein targeting to membrane regulation of translation ribosome biogenesis positive regulation of mitochondrial translationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez54471239555EnsemblENSG00000100335ENSMUSG00000022412UniProtL0R8F8Q8BGV8RefSeq mRNA NM 001304564NM 013298NM 019008NM 001394030NM 178719NM 001357659NM 001357660RefSeq protein NP 001291493NP 061881NP 848834NP 001344588NP 001344589Location UCSC Chr 22 39 5 39 52 MbChr 15 80 12 80 14 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThe SMCR7L gene codes for a protein that has been called MiD51 MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000100335 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022412 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wiemann S Weil B Wellenreuther R Gassenhuber J Glassl S Ansorge W Bocher M Blocker H Bauersachs S Blum H Lauber J Dusterhoft A Beyer A Kohrer K Strack N Mewes HW Ottenwalder B Obermaier B Tampe J Heubner D Wambutt R Korn B Klein M Poustka A Mar 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA Jun 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Entrez Gene SMCR7L Smith Magenis syndrome chromosome region candidate 7 like Dikov D Reichert A S 2011 How to split up Lessons from mitochondria The EMBO Journal 30 14 2751 2753 doi 10 1038 emboj 2011 219 PMC 3160261 PMID 21772324 Further reading editYu W Andersson B Worley KC et al 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Dunham I Shimizu N Roe BA et al 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Hartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Simpson JC Wellenreuther R Poustka A et al 2001 Systematic subcellular localization of novel proteins identified by large scale cDNA sequencing EMBO Rep 1 3 287 92 doi 10 1093 embo reports kvd058 PMC 1083732 PMID 11256614 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Jin J Smith FD Stark C et al 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization Curr Biol 14 16 1436 50 doi 10 1016 j cub 2004 07 051 PMID 15324660 S2CID 2371325 Wiemann S Arlt D Huber W et al 2004 From ORFeome to biology a functional genomics pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SMCR7L amp oldid 1136296581, wikipedia, wiki, book, books, library,
