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FIS1

October 22, 2023

Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7.[5][6][7] This protein is a component of a mitochondrial complex, the ARCosome, that promotes mitochondrial fission.[7][8] Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis.[7][8][9][10] By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.[11][12]

FIS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFIS1, TTC11, CGI-135, fission, mitochondrial 1
External IDsOMIM: 609003 MGI: 1913687 HomoloGene: 41099 GeneCards: FIS1
Orthologs
SpeciesHumanMouse
Entrez

51024

66437

Ensembl

ENSG00000214253

ENSMUSG00000019054

UniProt

Q9Y3D6

Q9CQ92

RefSeq (mRNA)

NM_016068

NM_001163243
NM_025562
NM_001347504

RefSeq (protein)

NP_057152

NP_001156715
NP_001334433
NP_079838

Location (UCSC)Chr 7: 101.24 – 101.25 MbChr 5: 136.98 – 137 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure Edit

The protein encoded by this gene is a 16 kDa integral protein situated in the outer mitochondrial membrane (OMM).[9] It is composed of a transmembrane domain at the C-terminal and a cytosolic domain at the N-terminal.[9][13][14] The transmembrane domain anchors FIS1 in the OMM, though it has been observed to target different cellular compartments, such as the peroxisome, depending on its hydrophobicity, charge, and length.[14][15] Meanwhile, the cytosolic domain contains a bundle of six helices, four of which contain two tandem tetratricopeptide repeat (TPR)-like motifs. These motifs form a concave surface by their combined superhelical structure and potentially bind another FIS1 protein to form a dimer, or other proteins.[9][13] Moreover, the N-terminal arm can dock at, and thus obstruct, the TPR motifs, allowing the protein to exist in a dynamic equilibrium between “open” and “closed” states.[13]

Function Edit

FIS1 is indirectly involved in mitochondrial fission via binding dynamin-related protein 1 (DRP1).[12][15] By extension, FIS1 helps regulate the size and distribution of mitochondria in response to local demand for ATP or calcium ions.[13] In addition, mitochondrial fission may lead to release of cytochrome C, which eventually leads to cell death.[9] In a separate apoptotic signalling pathway, FIS1 interacts with BCAP31 to form a complex, the ARCosome. The ARCosome promotes cell death by bridging the mitochondria and the endoplasmic reticulum (ER), allowing FIS1 to transmit a proapoptotic signal from the mitochondria to the ER and activate procaspase-8. The ARCosome then forms a platform with procaspase-8 to increase calcium load in the mitochondria, resulting in apoptosis.[8][12] Additionally, FIS1 is involved in other modes of shaping mitochondrial morphology. For example, it interacts with TBC1D15 to regulate mitochondrial morphology, particularly with regard to lysosome and endosome fusion.[14] FIS1 also prevents mitochondria elongation, which would otherwise lead to cell cycle delay or arrest, and ultimately, senescence. Moreover, mitochondrial dysfunction results in elevated reactive oxygen species (ROS) levels, which cause DNA damage and induce transcriptional repression, as well as induce mitophagy.[9][10]

Clinical Significance Edit

As a fission factor, FIS1 is associated with neurodegenerative diseases.[11][12] Stress, such as NO, can trigger aberrant mitochondrial fission and fusion, resulting in mitophagy.[9][11] For example, increased mitochondrial fragmentation and FIS1 levels were observed in Alzheimer’s disease (AD) patients. Thus, FIS1 could serve as a biomarker for early detection of AD.[11] FIS1 is also implicated in a variety of cancers, including acute myeloid leukemia, breast cancer, and prostate cancer.[12]

Interactions Edit

FIS1 has been shown to interact with:

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214253 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019054 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (Mar 2004). "Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology". Journal of Cell Science. 117 (Pt 7): 1201–10. doi:10.1242/jcs.01058. PMID 14996942.
  6. ^ Kong D, Xu L, Yu Y, Zhu W, Andrews DW, Yoon Y, Kuo TH (Apr 2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1". Molecular and Cellular Biochemistry. 272 (1–2): 187–99. doi:10.1007/s11010-005-7323-3. PMID 16010987. S2CID 21452703.
  7. ^ a b c "Entrez Gene: FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)".
  8. ^ a b c d e Iwasawa R, Mahul-Mellier AL, Datler C, Pazarentzos E, Grimm S (Feb 2011). "Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction". The EMBO Journal. 30 (3): 556–68. doi:10.1038/emboj.2010.346. PMC 3034017. PMID 21183955.
  9. ^ a b c d e f g Gomes LC, Scorrano L (2008). "High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777 (7–8): 860–6. doi:10.1016/j.bbabio.2008.05.442. PMID 18515060.
  10. ^ a b Lee S, Park YY, Kim SH, Nguyen OT, Yoo YS, Chan GK, Sun X, Cho H (Feb 2014). "Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition". Cellular and Molecular Life Sciences. 71 (4): 711–25. doi:10.1007/s00018-013-1428-8. PMID 23907611. S2CID 11694077.
  11. ^ a b c d Wang S, Song J, Tan M, Albers KM, Jia J (Jul 2012). "Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease". European Journal of Neurology. 19 (7): 1015–22. doi:10.1111/j.1468-1331.2012.03670.x. PMID 22340708. S2CID 21950507.
  12. ^ a b c d e Tian Y, Huang Z, Wang Z, Yin C, Zhou L, Zhang L, Huang K, Zhou H, Jiang X, Li J, Liao L, Yang M, Meng F (2014). "Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia". PLOS ONE. 9 (1): e84150. Bibcode:2014PLoSO...984150T. doi:10.1371/journal.pone.0084150. PMC 3885535. PMID 24416201.
  13. ^ a b c d Lees JP, Manlandro CM, Picton LK, Tan AZ, Casares S, Flanagan JM, Fleming KG, Hill RB (Oct 2012). "A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission". Journal of Molecular Biology. 423 (2): 143–58. doi:10.1016/j.jmb.2012.06.042. PMC 3456991. PMID 22789569.
  14. ^ a b c d Onoue K, Jofuku A, Ban-Ishihara R, Ishihara T, Maeda M, Koshiba T, Itoh T, Fukuda M, Otera H, Oka T, Takano H, Mizushima N, Mihara K, Ishihara N (Jan 2013). "Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology". Journal of Cell Science. 126 (Pt 1): 176–85. doi:10.1242/jcs.111211. PMID 23077178.
  15. ^ a b c Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT (Sep 2013). "Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission". The Journal of Biological Chemistry. 288 (38): 27584–93. doi:10.1074/jbc.M113.479873. PMC 3779755. PMID 23921378.
  16. ^ Yoon Y, Krueger EW, Oswald BJ, McNiven MA (Aug 2003). "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1". Molecular and Cellular Biology. 23 (15): 5409–20. doi:10.1128/MCB.23.15.5409-5420.2003. PMC 165727. PMID 12861026.

Further reading Edit

  • Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • James DI, Parone PA, Mattenberger Y, Martinou JC (Sep 2003). "hFis1, a novel component of the mammalian mitochondrial fission machinery". The Journal of Biological Chemistry. 278 (38): 36373–9. doi:10.1074/jbc.M303758200. PMID 12783892.
  • Yoon Y, Krueger EW, Oswald BJ, McNiven MA (Aug 2003). "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1". Molecular and Cellular Biology. 23 (15): 5409–20. doi:10.1128/MCB.23.15.5409-5420.2003. PMC 165727. PMID 12861026.
  • Kikuchi M, Hatano N, Yokota S, Shimozawa N, Imanaka T, Taniguchi H (Jan 2004). "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease". The Journal of Biological Chemistry. 279 (1): 421–8. doi:10.1074/jbc.M305623200. PMID 14561759.
  • Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N (Nov 2003). "The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle". Journal of Molecular Biology. 334 (3): 445–58. doi:10.1016/j.jmb.2003.09.064. PMID 14623186.
  • Dohm JA, Lee SJ, Hardwick JM, Hill RB, Gittis AG (Jan 2004). "Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold". Proteins. 54 (1): 153–6. doi:10.1002/prot.10524. PMC 3047745. PMID 14705031.
  • Frieden M, James D, Castelbou C, Danckaert A, Martinou JC, Demaurex N (May 2004). "Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1". The Journal of Biological Chemistry. 279 (21): 22704–14. doi:10.1074/jbc.M312366200. PMID 15024001.
  • Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ (Nov 2004). "Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis". Molecular Biology of the Cell. 15 (11): 5001–11. doi:10.1091/mbc.E04-04-0294. PMC 524759. PMID 15356267.
  • Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M (Nov 2005). "A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell. 16 (11): 5077–86. doi:10.1091/mbc.E05-02-0159. PMC 1266408. PMID 16107562.
  • Yu T, Fox RJ, Burwell LS, Yoon Y (Sep 2005). "Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1". Journal of Cell Science. 118 (Pt 18): 4141–51. doi:10.1242/jcs.02537. PMID 16118244.
  • Yoon YS, Yoon DS, Lim IK, Yoon SH, Chung HY, Rojo M, Malka F, Jou MJ, Martinou JC, Yoon G (Nov 2006). "Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1". Journal of Cellular Physiology. 209 (2): 468–80. doi:10.1002/jcp.20753. PMID 16883569. S2CID 22179820.
  • Alirol E, James D, Huber D, Marchetto A, Vergani L, Martinou JC, Scorrano L (Nov 2006). "The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis". Molecular Biology of the Cell. 17 (11): 4593–605. doi:10.1091/mbc.E06-05-0377. PMC 1635393. PMID 16914522.
  • Kobayashi S, Tanaka A, Fujiki Y (May 2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Experimental Cell Research. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.
  • Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H (Aug 2007). "Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence". The Journal of Biological Chemistry. 282 (31): 22977–83. doi:10.1074/jbc.M700679200. PMID 17545159.

October 22, 2023
fis1, mitochondrial, fission, protein, protein, that, humans, encoded, gene, chromosome, this, protein, component, mitochondrial, complex, arcosome, that, promotes, mitochondrial, fission, role, mitochondrial, fission, thus, implicates, regulation, mitochondri. Mitochondrial fission 1 protein FIS1 is a protein that in humans is encoded by the FIS1 gene on chromosome 7 5 6 7 This protein is a component of a mitochondrial complex the ARCosome that promotes mitochondrial fission 7 8 Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology the cell cycle and apoptosis 7 8 9 10 By extension the protein is involved in associated diseases including neurodegenerative diseases and cancers 11 12 FIS1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1NZN 1PC2IdentifiersAliasesFIS1 TTC11 CGI 135 fission mitochondrial 1External IDsOMIM 609003 MGI 1913687 HomoloGene 41099 GeneCards FIS1Gene location Human Chr Chromosome 7 human 1 Band7q22 1Start101 239 458 bp 1 End101 252 316 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 G2Start136 982 129 bp 2 End136 995 088 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inprefrontal cortexanterior pituitarygastrocnemius muscleleft ventriclegastric mucosaoptic nervetibial nerveright lobe of thyroid glandamygdalaright adrenal glandTop expressed ininterventricular septumbloodsuperior frontal gyrusvisual cortexlipright lung lobeneural tubecerebellar cortexolfactory epitheliummedial ganglionic eminenceMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding signaling receptor binding protein containing complex bindingCellular componentintegral component of membrane membrane peroxisomal membrane peroxisome mitochondrial outer membrane mitochondrion integral component of peroxisomal membrane endoplasmic reticulum integral component of mitochondrial outer membrane protein containing complexBiological processmitochondrial fusion mitochondrial fission regulation of mitochondrion organization positive regulation of cytosolic calcium ion concentration protein targeting to mitochondrion peroxisome fission positive regulation of cysteine type endopeptidase activity involved in apoptotic process autophagy of mitochondrion negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration mitochondrion morphogenesis calcium mediated signaling using intracellular calcium source positive regulation of intrinsic apoptotic signaling pathway release of cytochrome c from mitochondria positive regulation of protein targeting to membrane apoptotic process response to muscle activity cellular response to glucose stimulus cellular response to toxic substance response to hypobaric hypoxia positive regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process protein homooligomerization cellular response to lipid positive regulation of mitochondrial fission cellular response to peptide response to flavonoid response to nutrient levels response to fluorideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5102466437EnsemblENSG00000214253ENSMUSG00000019054UniProtQ9Y3D6Q9CQ92RefSeq mRNA NM 016068NM 001163243NM 025562NM 001347504RefSeq protein NP 057152NP 001156715NP 001334433NP 079838Location UCSC Chr 7 101 24 101 25 MbChr 5 136 98 137 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Structure 2 Function 3 Clinical Significance 4 Interactions 5 References 6 Further readingStructure EditThe protein encoded by this gene is a 16 kDa integral protein situated in the outer mitochondrial membrane OMM 9 It is composed of a transmembrane domain at the C terminal and a cytosolic domain at the N terminal 9 13 14 The transmembrane domain anchors FIS1 in the OMM though it has been observed to target different cellular compartments such as the peroxisome depending on its hydrophobicity charge and length 14 15 Meanwhile the cytosolic domain contains a bundle of six helices four of which contain two tandem tetratricopeptide repeat TPR like motifs These motifs form a concave surface by their combined superhelical structure and potentially bind another FIS1 protein to form a dimer or other proteins 9 13 Moreover the N terminal arm can dock at and thus obstruct the TPR motifs allowing the protein to exist in a dynamic equilibrium between open and closed states 13 Function EditFIS1 is indirectly involved in mitochondrial fission via binding dynamin related protein 1 DRP1 12 15 By extension FIS1 helps regulate the size and distribution of mitochondria in response to local demand for ATP or calcium ions 13 In addition mitochondrial fission may lead to release of cytochrome C which eventually leads to cell death 9 In a separate apoptotic signalling pathway FIS1 interacts with BCAP31 to form a complex the ARCosome The ARCosome promotes cell death by bridging the mitochondria and the endoplasmic reticulum ER allowing FIS1 to transmit a proapoptotic signal from the mitochondria to the ER and activate procaspase 8 The ARCosome then forms a platform with procaspase 8 to increase calcium load in the mitochondria resulting in apoptosis 8 12 Additionally FIS1 is involved in other modes of shaping mitochondrial morphology For example it interacts with TBC1D15 to regulate mitochondrial morphology particularly with regard to lysosome and endosome fusion 14 FIS1 also prevents mitochondria elongation which would otherwise lead to cell cycle delay or arrest and ultimately senescence Moreover mitochondrial dysfunction results in elevated reactive oxygen species ROS levels which cause DNA damage and induce transcriptional repression as well as induce mitophagy 9 10 Clinical Significance EditAs a fission factor FIS1 is associated with neurodegenerative diseases 11 12 Stress such as NO can trigger aberrant mitochondrial fission and fusion resulting in mitophagy 9 11 For example increased mitochondrial fragmentation and FIS1 levels were observed in Alzheimer s disease AD patients Thus FIS1 could serve as a biomarker for early detection of AD 11 FIS1 is also implicated in a variety of cancers including acute myeloid leukemia breast cancer and prostate cancer 12 Interactions EditFIS1 has been shown to interact with BCAP31 8 procaspase 8 8 TBC1D15 14 PEX11 family 15 and DNM1L 16 References Edit a b c GRCh38 Ensembl release 89 ENSG00000214253 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000019054 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Stojanovski D Koutsopoulos OS Okamoto K Ryan MT Mar 2004 Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology Journal of Cell Science 117 Pt 7 1201 10 doi 10 1242 jcs 01058 PMID 14996942 Kong D Xu L Yu Y Zhu W Andrews DW Yoon Y Kuo TH Apr 2005 Regulation of Ca2 induced permeability transition by Bcl 2 is antagonized by Drpl and hFis1 Molecular and Cellular Biochemistry 272 1 2 187 99 doi 10 1007 s11010 005 7323 3 PMID 16010987 S2CID 21452703 a b c Entrez Gene FIS1 fission 1 mitochondrial outer membrane homolog S cerevisiae a b c d e Iwasawa R Mahul Mellier AL Datler C Pazarentzos E Grimm S Feb 2011 Fis1 and Bap31 bridge the mitochondria ER interface to establish a platform for apoptosis induction The EMBO Journal 30 3 556 68 doi 10 1038 emboj 2010 346 PMC 3034017 PMID 21183955 a b c d e f g Gomes LC Scorrano L 2008 High levels of Fis1 a pro fission mitochondrial protein trigger autophagy Biochimica et Biophysica Acta BBA Bioenergetics 1777 7 8 860 6 doi 10 1016 j bbabio 2008 05 442 PMID 18515060 a b Lee S Park YY Kim SH Nguyen OT Yoo YS Chan GK Sun X Cho H Feb 2014 Human mitochondrial Fis1 links to cell cycle regulators at G2 M transition Cellular and Molecular Life Sciences 71 4 711 25 doi 10 1007 s00018 013 1428 8 PMID 23907611 S2CID 11694077 a b c d Wang S Song J Tan M Albers KM Jia J Jul 2012 Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer s disease European Journal of Neurology 19 7 1015 22 doi 10 1111 j 1468 1331 2012 03670 x PMID 22340708 S2CID 21950507 a b c d e Tian Y Huang Z Wang Z Yin C Zhou L Zhang L Huang K Zhou H Jiang X Li J Liao L Yang M Meng F 2014 Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia over expression of PDCD7 FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia PLOS ONE 9 1 e84150 Bibcode 2014PLoSO 984150T doi 10 1371 journal pone 0084150 PMC 3885535 PMID 24416201 a b c d Lees JP Manlandro CM Picton LK Tan AZ Casares S Flanagan JM Fleming KG Hill RB Oct 2012 A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission Journal of Molecular Biology 423 2 143 58 doi 10 1016 j jmb 2012 06 042 PMC 3456991 PMID 22789569 a b c d Onoue K Jofuku A Ban Ishihara R Ishihara T Maeda M Koshiba T Itoh T Fukuda M Otera H Oka T Takano H Mizushima N Mihara K Ishihara N Jan 2013 Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology Journal of Cell Science 126 Pt 1 176 85 doi 10 1242 jcs 111211 PMID 23077178 a b c Palmer CS Elgass KD Parton RG Osellame LD Stojanovski D Ryan MT Sep 2013 Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission The Journal of Biological Chemistry 288 38 27584 93 doi 10 1074 jbc M113 479873 PMC 3779755 PMID 23921378 Yoon Y Krueger EW Oswald BJ McNiven MA Aug 2003 The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin like protein DLP1 Molecular and Cellular Biology 23 15 5409 20 doi 10 1128 MCB 23 15 5409 5420 2003 PMC 165727 PMID 12861026 Further reading EditLai CH Chou CY Ch ang LY Liu CS Lin W May 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics Genome Research 10 5 703 13 doi 10 1101 gr 10 5 703 PMC 310876 PMID 10810093 James DI Parone PA Mattenberger Y Martinou JC Sep 2003 hFis1 a novel component of the mammalian mitochondrial fission machinery The Journal of Biological Chemistry 278 38 36373 9 doi 10 1074 jbc M303758200 PMID 12783892 Yoon Y Krueger EW Oswald BJ McNiven MA Aug 2003 The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin like protein DLP1 Molecular and Cellular Biology 23 15 5409 20 doi 10 1128 MCB 23 15 5409 5420 2003 PMC 165727 PMID 12861026 Kikuchi M Hatano N Yokota S Shimozawa N Imanaka T Taniguchi H Jan 2004 Proteomic analysis of rat liver peroxisome presence of peroxisome specific isozyme of Lon protease The Journal of Biological Chemistry 279 1 421 8 doi 10 1074 jbc M305623200 PMID 14561759 Suzuki M Jeong SY Karbowski M Youle RJ Tjandra N Nov 2003 The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR like helix bundle Journal of Molecular Biology 334 3 445 58 doi 10 1016 j jmb 2003 09 064 PMID 14623186 Dohm JA Lee SJ Hardwick JM Hill RB Gittis AG Jan 2004 Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold Proteins 54 1 153 6 doi 10 1002 prot 10524 PMC 3047745 PMID 14705031 Frieden M James D Castelbou C Danckaert A Martinou JC Demaurex N May 2004 Ca 2 homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1 The Journal of Biological Chemistry 279 21 22704 14 doi 10 1074 jbc M312366200 PMID 15024001 Lee YJ Jeong SY Karbowski M Smith CL Youle RJ Nov 2004 Roles of the mammalian mitochondrial fission and fusion mediators Fis1 Drp1 and Opa1 in apoptosis Molecular Biology of the Cell 15 11 5001 11 doi 10 1091 mbc E04 04 0294 PMC 524759 PMID 15356267 Koch A Yoon Y Bonekamp NA McNiven MA Schrader M Nov 2005 A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells Molecular Biology of the Cell 16 11 5077 86 doi 10 1091 mbc E05 02 0159 PMC 1266408 PMID 16107562 Yu T Fox RJ Burwell LS Yoon Y Sep 2005 Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1 Journal of Cell Science 118 Pt 18 4141 51 doi 10 1242 jcs 02537 PMID 16118244 Yoon YS Yoon DS Lim IK Yoon SH Chung HY Rojo M Malka F Jou MJ Martinou JC Yoon G Nov 2006 Formation of elongated giant mitochondria in DFO induced cellular senescence involvement of enhanced fusion process through modulation of Fis1 Journal of Cellular Physiology 209 2 468 80 doi 10 1002 jcp 20753 PMID 16883569 S2CID 22179820 Alirol E James D Huber D Marchetto A Vergani L Martinou JC Scorrano L Nov 2006 The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis Molecular Biology of the Cell 17 11 4593 605 doi 10 1091 mbc E06 05 0377 PMC 1635393 PMID 16914522 Kobayashi S Tanaka A Fujiki Y May 2007 Fis1 DLP1 and Pex11p coordinately regulate peroxisome morphogenesis Experimental Cell Research 313 8 1675 86 doi 10 1016 j yexcr 2007 02 028 PMID 17408615 Lee S Jeong SY Lim WC Kim S Park YY Sun X Youle RJ Cho H Aug 2007 Mitochondrial fission and fusion mediators hFis1 and OPA1 modulate cellular senescence The Journal of Biological Chemistry 282 31 22977 83 doi 10 1074 jbc M700679200 PMID 17545159 Retrieved from https en wikipedia org w index php title FIS1 amp oldid 1082544369, wikipedia, wiki, book, books, library,

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