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Wikipedia

LY9

January 01, 1970

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[5][6][7] LY9 has also recently been designated CD229 (cluster of differentiation 229).

LY9
Identifiers
AliasesLY9, CD229, SLAMF3, hly9, mlymphocyte antigen 9
External IDsOMIM: 600684; MGI: 96885; HomoloGene: 1759; GeneCards: LY9; OMA:LY9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4063

17085

Ensembl

ENSG00000122224

ENSMUSG00000004707

UniProt

Q9HBG7
Q5VYI1

Q01965

RefSeq (mRNA)

NM_001033667
NM_001261456
NM_001261457
NM_002348

NM_001277968
NM_008534

RefSeq (protein)

NP_001028839
NP_001248385
NP_001248386
NP_002339

NP_001264897
NP_032560

Location (UCSC)Chr 1: 160.8 – 160.83 MbChr 1: 171.42 – 171.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

LY9 has been shown to interact with SH2D1A.[8][9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics. 43 (1–2): 13–9. doi:10.1007/bf00186599. PMID 8537117. S2CID 10045488.
  6. ^ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269. S2CID 28529549.
  7. ^ "Entrez Gene: LY9 lymphocyte antigen 9".
  8. ^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  9. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.

Further reading edit

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P (2000). "Gene structure of the mouse leukocyte cell surface molecule Ly9". Immunogenetics. 51 (10): 788–793. doi:10.1007/s002510000209. PMID 10970093. S2CID 23932012.
  • de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P (2001). "Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9". Blood. 97 (11): 3513–3520. doi:10.1182/blood.V97.11.3513. PMID 11369645.
  • Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  • Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. hdl:2437/230556. PMID 11477068.
  • Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–5852. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
  • Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P (2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors". Immunogenetics. 54 (6): 394–402. doi:10.1007/s00251-002-0483-3. PMID 12242590. S2CID 38277782.
  • Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–17437. doi:10.1074/jbc.M301569200. PMID 12621057.
  • Martín M, Del Valle JM, Saborit I, Engel P (2005). "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229". J. Immunol. 174 (10): 5977–86. doi:10.4049/jimmunol.174.10.5977. PMID 15879090.
  • Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P (2005). "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse". J. Immunol. 174 (11): 7033–42. doi:10.4049/jimmunol.174.11.7033. PMID 15905546.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

January 01, 1970
lymphocyte, surface, antigen, protein, that, humans, encoded, gene, also, recently, been, designated, cd229, cluster, differentiation, identifiersaliases, cd229, slamf3, hly9, mlymphocyte, antigen, 9external, idsomim, 600684, 96885, homologene, 1759, genecards. T lymphocyte surface antigen Ly 9 is a protein that in humans is encoded by the LY9 gene 5 6 7 LY9 has also recently been designated CD229 cluster of differentiation 229 LY9IdentifiersAliasesLY9 CD229 SLAMF3 hly9 mlymphocyte antigen 9External IDsOMIM 600684 MGI 96885 HomoloGene 1759 GeneCards LY9 OMA LY9 orthologsGene location Human Chr Chromosome 1 human 1 Band1q23 3Start160 796 074 bp 1 End160 828 261 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H3 1 79 54 cMStart171 416 192 bp 2 End171 434 978 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodebloodspleenbone marrow cellssuperficial temporal arteryappendixtrabecular bonethymusamniotic fluidthymusTop expressed inthymusspleenbloodsubcutaneous adipose tissuecalvariawhite adipose tissueright lung lobespermatocytethighduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmolecular functionCellular componentintegral component of membrane cell surface plasma membrane membraneBiological processpositive regulation of interleukin 17 production innate immune response cell adhesion adaptive immune response T helper 17 cell lineage commitment immune system processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez406317085EnsemblENSG00000122224ENSMUSG00000004707UniProtQ9HBG7Q5VYI1Q01965RefSeq mRNA NM 001033667NM 001261456NM 001261457NM 002348NM 001277968NM 008534RefSeq protein NP 001028839NP 001248385NP 001248386NP 002339NP 001264897NP 032560Location UCSC Chr 1 160 8 160 83 MbChr 1 171 42 171 43 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editLY9 has been shown to interact with SH2D1A 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000122224 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004707 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sandrin MS Henning MM Lo MF Baker E Sutherland GR McKenzie IF Feb 1996 Isolation and characterization of cDNA clones for Humly9 the human homologue of mouse Ly9 Immunogenetics 43 1 2 13 9 doi 10 1007 bf00186599 PMID 8537117 S2CID 10045488 Kingsmore SF Souryal CA Watson ML Patel DD Seldin MF Aug 1995 Physical and genetic linkage of the genes encoding Ly 9 and CD48 on mouse and human chromosomes 1 Immunogenetics 42 1 59 62 doi 10 1007 BF00164988 PMID 7797269 S2CID 28529549 Entrez Gene LY9 lymphocyte antigen 9 Sayos J Martin M Chen A Simarro M Howie D Morra M Engel P Terhorst C Jun 2001 Cell surface receptors Ly 9 and CD84 recruit the X linked lymphoproliferative disease gene product SAP Blood 97 12 3867 3874 doi 10 1182 blood V97 12 3867 PMID 11389028 Morra M Simarro Grande M Martin M Chen AS Lanyi A Silander O Calpe S Davis J Pawson T Eck MJ Sumegi J Engel P Li SC Terhorst C Sep 2001 Characterization of SH2D1A missense mutations identified in X linked lymphoproliferative disease patients PDF J Biol Chem 276 39 36809 36816 doi 10 1074 jbc M101305200 PMID 11477068 S2CID 39889619 Further reading editAndersson B Wentland MA Ricafrente JY Liu W Gibbs RA 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 113 doi 10 1006 abio 1996 0138 PMID 8619474 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Tovar V de la Fuente MA Pizcueta P Bosch J Engel P 2000 Gene structure of the mouse leukocyte cell surface molecule Ly9 Immunogenetics 51 10 788 793 doi 10 1007 s002510000209 PMID 10970093 S2CID 23932012 de la Fuente MA Tovar V Villamor N Zapater N Pizcueta P Campo E Bosch J Engel P 2001 Molecular characterization and expression of a novel human leukocyte cell surface marker homologous to mouse Ly 9 Blood 97 11 3513 3520 doi 10 1182 blood V97 11 3513 PMID 11369645 Sayos J Martin M Chen A Simarro M Howie D Morra M Engel P Terhorst C 2001 Cell surface receptors Ly 9 and CD84 recruit the X linked lymphoproliferative disease gene product SAP Blood 97 12 3867 3874 doi 10 1182 blood V97 12 3867 PMID 11389028 Morra M Simarro Grande M Martin M Chen AS Lanyi A Silander O Calpe S Davis J Pawson T Eck MJ Sumegi J Engel P Li SC Terhorst C 2001 Characterization of SH2D1A missense mutations identified in X linked lymphoproliferative disease patients J Biol Chem 276 39 36809 36816 doi 10 1074 jbc M101305200 hdl 2437 230556 PMID 11477068 Morra M Lu J Poy F Martin M Sayos J Calpe S Gullo C Howie D Rietdijk S Thompson A Coyle AJ Denny C Yaffe MB Engel P Eck MJ Terhorst C 2001 Structural basis for the interaction of the free SH2 domain EAT 2 with SLAM receptors in hematopoietic cells EMBO J 20 21 5840 5852 doi 10 1093 emboj 20 21 5840 PMC 125701 PMID 11689425 Tovar V del Valle J Zapater N Martin M Romero X Pizcueta P Bosch J Terhorst C Engel P 2002 Mouse novel Ly9 a new member of the expanding CD150 SLAM family of leukocyte cell surface receptors Immunogenetics 54 6 394 402 doi 10 1007 s00251 002 0483 3 PMID 12242590 S2CID 38277782 Del Valle JM Engel P Martin M 2003 The cell surface expression of SAP binding receptor CD229 is regulated via its interaction with clathrin associated adaptor complex 2 AP 2 J Biol Chem 278 19 17430 17437 doi 10 1074 jbc M301569200 PMID 12621057 Martin M Del Valle JM Saborit I Engel P 2005 Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule associated protein binding receptor CD229 J Immunol 174 10 5977 86 doi 10 4049 jimmunol 174 10 5977 PMID 15879090 Romero X Zapater N Calvo M Kalko SG de la Fuente MA Tovar V Ockeloen C Pizcueta P Engel P 2005 CD229 Ly9 lymphocyte cell surface receptor interacts homophilically through its N terminal domain and relocalizes to the immunological synapse J Immunol 174 11 7033 42 doi 10 4049 jimmunol 174 11 7033 PMID 15905546 External links editLY9 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LY9 amp oldid 1193502685, wikipedia, wiki, book, books, library,

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