Serpin B9 is a protein that in humans is encoded by the SERPINB9gene.[5][6][7] PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM][7]
^ abcGRCh38: Ensembl release 89: ENSG00000170542 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045827 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
^Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835. S2CID 23659776.
^ ab"Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".
Further readingedit
Sun J, Bird CH, Sutton V, et al. (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. doi:10.1074/jbc.271.44.27802. PMID 8910377.
Annand RR, Dahlen JR, Sprecher CA, et al. (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3 (3): 655–65. doi:10.1042/0264-6021:3420655. PMC1220507. PMID 10477277.
Kanamori H, Krieg S, Mao C, et al. (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. doi:10.1074/jbc.275.8.5867. PMID 10681578.
Bladergroen BA, Strik MC, Bovenschen N, et al. (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. doi:10.4049/jimmunol.166.5.3218. PMID 11207275.
Buzza MS, Hirst CE, Bird CH, et al. (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID 11485349.
Hirst CE, Buzza MS, Sutton VR, et al. (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. doi:10.1093/molehr/7.12.1133. PMID 11719590.
Tanaka K, Harashima N, Niiya F, et al. (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. doi:10.1111/j.1349-7006.2002.tb01259.x. PMC5926951. PMID 11856484.
ten Berge RL, Meijer CJ, Dukers DF, et al. (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood. 99 (12): 4540–6. doi:10.1182/blood.V99.12.4540. PMID 12036886.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Hirst CE, Buzza MS, Bird CH, et al. (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. doi:10.4049/jimmunol.170.2.805. PMID 12517944.
Rowshani AT, Florquin S, Bemelman F, et al. (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi:10.1111/j.1523-1755.2004.00903.x. PMID 15458434.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B". J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.
Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica. 89 (11): 1314–21. PMID 15531453.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi:10.1158/1078-0432.CCR-05-0306. PMID 16144945.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
External linksedit
The MEROPS online database for peptidases and their inhibitors: I04.014
SERPINB9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
serpinb9, serpin, protein, that, humans, encoded, gene, belongs, large, superfamily, serine, proteinase, inhibitors, serpins, which, bind, inactivate, serine, proteinases, these, interactions, involved, many, cellular, processes, including, coagulation, fibrin. Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene 5 6 7 PI9 belongs to the large superfamily of serine proteinase inhibitors serpins which bind to and inactivate serine proteinases These interactions are involved in many cellular processes including coagulation fibrinolysis complement fixation matrix remodeling and apoptosis Sprecher et al 1995 supplied by OMIM 7 SERPINB9IdentifiersAliasesSERPINB9 CAP 3 CAP3 PI 9 PI9 serpin family B member 9External IDsOMIM 601799 MGI 106603 HomoloGene 37888 GeneCards SERPINB9 OMA SERPINB9 orthologsGene location Human Chr Chromosome 6 human 1 Band6p25 2Start2 887 270 bp 1 End2 903 309 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 A3 2 A3 3 13 13 79 cMStart33 187 233 bp 2 End33 201 940 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytegerminal epitheliumappendixlymph nodeplacentatibial nervebloodspleenoocyteendothelial cellTop expressed inright lung lobeleft lungleft lung lobeplacentacarotid bodyspleensubcutaneous adipose tissueirisatrioventricular valvecalvariaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionpeptidase inhibitor activity cysteine type endopeptidase inhibitor activity involved in apoptotic process protease binding protein binding serine type endopeptidase inhibitor activityCellular componentcytosol membrane intracellular anatomical structure extracellular exosome nucleus cytoplasm extracellular space nucleoplasm Golgi apparatus collagen containing extracellular matrixBiological processnegative regulation of peptidase activity mast cell mediated immunity negative regulation of apoptotic process protection from natural killer cell mediated cytotoxicity cellular response to estrogen stimulus positive regulation of gene expression negative regulation by symbiont of host apoptotic process immune response negative regulation of endopeptidase activity apoptotic process negative regulation of cysteine type endopeptidase activity involved in apoptotic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez527220723EnsemblENSG00000170542ENSMUSG00000045827UniProtP50453O08797RefSeq mRNA NM 004155NM 009256RefSeq protein NP 004146NP 004146 1NP 033282Location UCSC Chr 6 2 89 2 9 MbChr 13 33 19 33 2 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 See also 2 References 3 Further reading 4 External linksSee also editSerpinReferences edit a b c GRCh38 Ensembl release 89 ENSG00000170542 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000045827 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sprecher CA Morgenstern KA Mathewes S Dahlen JR Schrader SK Foster DC Kisiel W Jan 1996 Molecular cloning expression and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors J Biol Chem 270 50 29854 61 doi 10 1074 jbc 270 50 29854 PMID 8530382 Sun J Stephens R Mirza G Kanai H Ragoussis J Bird PI Feb 1999 A serpin gene cluster on human chromosome 6p25 contains PI6 PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes Cytogenet Cell Genet 82 3 4 273 7 doi 10 1159 000015118 PMID 9858835 S2CID 23659776 a b Entrez Gene SERPINB9 serpin peptidase inhibitor clade B ovalbumin member 9 Further reading editSun J Bird CH Sutton V et al 1996 A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes J Biol Chem 271 44 27802 9 doi 10 1074 jbc 271 44 27802 PMID 8910377 Annand RR Dahlen JR Sprecher CA et al 1999 Caspase 1 interleukin 1beta converting enzyme is inhibited by the human serpin analogue proteinase inhibitor 9 Biochem J 342 Pt 3 3 655 65 doi 10 1042 0264 6021 3420655 PMC 1220507 PMID 10477277 Kanamori H Krieg S Mao C et al 2000 Proteinase inhibitor 9 an inhibitor of granzyme B mediated apoptosis is a primary estrogen inducible gene in human liver cells J Biol Chem 275 8 5867 73 doi 10 1074 jbc 275 8 5867 PMID 10681578 Bladergroen BA Strik MC Bovenschen N et al 2001 The granzyme B inhibitor protease inhibitor 9 is mainly expressed by dendritic cells and at immune privileged sites J Immunol 166 5 3218 25 doi 10 4049 jimmunol 166 5 3218 PMID 11207275 Buzza MS Hirst CE Bird CH et al 2001 The granzyme B inhibitor PI 9 is present in endothelial and mesothelial cells suggesting that it protects bystander cells during immune responses Cell Immunol 210 1 21 9 doi 10 1006 cimm 2001 1806 PMID 11485349 Hirst CE Buzza MS Sutton VR et al 2002 Perforin independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B mediated proteolysis in reproduction Mol Hum Reprod 7 12 1133 42 doi 10 1093 molehr 7 12 1133 PMID 11719590 Tanaka K Harashima N Niiya F et al 2002 Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients Jpn J Cancer Res 93 2 198 208 doi 10 1111 j 1349 7006 2002 tb01259 x PMC 5926951 PMID 11856484 ten Berge RL Meijer CJ Dukers DF et al 2002 Expression levels of apoptosis related proteins predict clinical outcome in anaplastic large cell lymphoma Blood 99 12 4540 6 doi 10 1182 blood V99 12 4540 PMID 12036886 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hirst CE Buzza MS Bird CH et al 2003 The intracellular granzyme B inhibitor proteinase inhibitor 9 is up regulated during accessory cell maturation and effector cell degranulation and its overexpression enhances CTL potency J Immunol 170 2 805 15 doi 10 4049 jimmunol 170 2 805 PMID 12517944 Rowshani AT Florquin S Bemelman F et al 2005 Hyperexpression of the granzyme B inhibitor PI 9 in human renal allografts a potential mechanism for stable renal function in patients with subclinical rejection Kidney Int 66 4 1417 22 doi 10 1111 j 1523 1755 2004 00903 x PMID 15458434 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Mahrus S Kisiel W Craik CS 2005 Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9 an endogenous inhibitor of granzyme B J Biol Chem 279 52 54275 82 doi 10 1074 jbc M411482200 PMID 15494398 Classen CF Ushmorov A Bird P Debatin KM 2006 The granzyme B inhibitor PI 9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias Haematologica 89 11 1314 21 PMID 15531453 Bruneel A Labas V Mailloux A et al 2006 Proteomics of human umbilical vein endothelial cells applied to etoposide induced apoptosis Proteomics 5 15 3876 84 doi 10 1002 pmic 200401239 PMID 16130169 S2CID 26007149 van Houdt IS Oudejans JJ van den Eertwegh AJ et al 2005 Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma Clin Cancer Res 11 17 6400 7 doi 10 1158 1078 0432 CCR 05 0306 PMID 16144945 Stelzl U Worm U Lalowski M et al 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 S2CID 8235923 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editThe MEROPS online database for peptidases and their inhibitors I04 014 SERPINB9 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SERPINB9 amp oldid 1142708940, wikipedia, wiki, book, books, library,
