Secretagogin

Secretagogin is a protein that in humans is encoded by the SCGN gene.^[5][6]

SCGN
Identifiers
Aliases	SCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDs	OMIM: 609202; MGI: 2384873; HomoloGene: 5088; GeneCards: SCGN; OMA:SCGN - orthologs
Gene location (Human) Chr. Chromosome 6 (human)^[1] Band 6p22.2 Start 25,652,201 bp^[1] End 25,701,783 bp^[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)^[2] Band 13|13 A3.1 Start 24,137,439 bp^[2] End 24,175,197 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas rectum pituitary gland cerebellar cortex cerebellar hemisphere anterior pituitary cerebellar vermis transverse colon ganglionic eminence Top expressed in islet of Langerhans olfactory epithelium spermatid lens olfactory bulb seminiferous tubule spermatocyte duodenum ileum germ layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding Cellular component cytoplasm extracellular region neuron projection cytosol transport vesicle membrane synapse membrane cytoplasmic vesicle nucleus dendrite presynapse Biological process regulation of cytosolic calcium ion concentration biological process regulation of presynaptic cytosolic calcium ion concentration regulation of long-term synaptic potentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10590 214189 Ensembl ENSG00000079689 ENSMUSG00000021337 UniProt O76038 Q91WD9 RefSeq (mRNA) NM_006998 NM_145399 RefSeq (protein) NP_008929 NP_663374 Location (UCSC) Chr 6: 25.65 – 25.7 Mb Chr 13: 24.14 – 24.18 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.^[6] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

1. GRCh38: Ensembl release 89: ENSG00000079689 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021337 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
6. "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

• Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein". Cereb. Cortex. 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas". Pituitary. 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930. S2CID 29004965.
• Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
• Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620. S2CID 13567265.
• Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release". EMBO Journal. 34 (1): 36–54. doi:10.15252/embj.201488977. PMC 4291479. PMID 25430741.
• Téllez de Meneses, Pablo G.; Pérez-Revuelta, Laura; Canal-Alonso, Ángel; Hernández-Pérez, Carlos; Cocho, Teresa; Valero, Jorge; Weruaga, Eduardo; Díaz, David; Alonso, José R. (2023). "Immunohistochemical distribution of secretagogin in the mouse brain". Frontiers in Neuroanatomy. 17. doi:10.3389/fnana.2023.1224342. PMC 10498459. PMID 37711587.