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SAT2

August 25, 2023

This article is about the human gene. For the submarine communications cable, see SAT-2. For the SAT II tests, see SAT Subject Tests.

Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[5][6][7] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[8]

SAT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSAT2, Sspermidine/spermine N1-acetyltransferase family member 2, SSAT-2
External IDsOMIM: 611463 MGI: 1916465 HomoloGene: 44215 GeneCards: SAT2
Orthologs
SpeciesHumanMouse
Entrez

112483

69215

Ensembl

ENSG00000141504

ENSMUSG00000069835

UniProt

Q96F10

Q6P8J2

RefSeq (mRNA)

NM_133491
NM_001320845
NM_001320846
NM_001320847

NM_026991
NM_001356468
NM_001356469

RefSeq (protein)

NP_001307774
NP_001307775
NP_001307776
NP_597998

NP_081267
NP_001343397
NP_001343398

Location (UCSC)Chr 17: 7.63 – 7.63 MbChr 11: 69.51 – 69.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141504 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069835 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.
  6. ^ Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.
  7. ^ "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
  8. ^ Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.

Further reading Edit

  • Baek JH, Liu YV, McDonald KR, et al. (2008). "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha". J. Biol. Chem. 282 (46): 33358–66. doi:10.1074/jbc.M705627200. PMID 17875644.
  • Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR". Mol. Cell. Biochem. 298 (1–2): 59–68. doi:10.1007/s11010-006-9350-0. hdl:11383/1672116. PMID 17119850. S2CID 29889795.
  • Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006). "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins. 64 (1): 288–93. doi:10.1002/prot.20967. PMID 16596569.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chen Y, Vujcic S, Liang P, et al. (2003). "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase". Biochem. J. 373 (Pt 3): 661–7. doi:10.1042/BJ20030734. PMC 1223561. PMID 12803540.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

August 25, 2023
sat2, this, article, about, human, gene, submarine, communications, cable, tests, subject, tests, diamine, acetyltransferase, enzyme, that, humans, encoded, gene, maintains, metabolic, glutamine, glutamate, balance, underpinning, retrograde, signaling, dendrit. This article is about the human gene For the submarine communications cable see SAT 2 For the SAT II tests see SAT Subject Tests Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene 5 6 7 SAT2 maintains a key metabolic glutamine glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate 8 SAT2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2BEI 2Q4VIdentifiersAliasesSAT2 Sspermidine spermine N1 acetyltransferase family member 2 SSAT 2External IDsOMIM 611463 MGI 1916465 HomoloGene 44215 GeneCards SAT2Gene location Human Chr Chromosome 17 human 1 Band17p13 1Start7 626 234 bp 1 End7 627 876 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B3Start69 512 850 bp 2 End69 514 696 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosaright lobe of liverduodenumkidneyanterior pituitarybody of pancreasBrodmann area 9renal medullaleft lobe of thyroid glandright lobe of thyroid glandTop expressed inotolith organutricleretinal pigment epitheliumproximal tubuleinternal carotid arteryexternal carotid arterypineal glandhandovaryleft lobe of liverMore reference expression dataBioGPSn aGene ontologyMolecular functiontransferase activity N acetyltransferase activity acyltransferase activity diamine N acetyltransferase activity protein binding identical protein binding spermidine bindingCellular componentcytoplasm extracellular exosomeBiological processputrescine acetylation spermine acetylation nor spermidine metabolic process spermidine acetylation putrescine catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez11248369215EnsemblENSG00000141504ENSMUSG00000069835UniProtQ96F10Q6P8J2RefSeq mRNA NM 133491NM 001320845NM 001320846NM 001320847NM 026991NM 001356468NM 001356469RefSeq protein NP 001307774NP 001307775NP 001307776NP 597998NP 081267NP 001343397NP 001343398Location UCSC Chr 17 7 63 7 63 MbChr 11 69 51 69 51 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000141504 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000069835 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Coleman CS Stanley BA Jones AD Pegg AE Nov 2004 Spermidine spermine N1 acetyltransferase 2 SSAT2 acetylates thialysine and is not involved in polyamine metabolism Biochem J 384 Pt 1 139 48 doi 10 1042 BJ20040790 PMC 1134097 PMID 15283699 Baek JH Liu YV McDonald KR Wesley JB Hubbi ME Byun H Semenza GL Aug 2007 Spermidine spermine N1 acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia inducible factor 1alpha J Biol Chem 282 32 23572 80 doi 10 1074 jbc M703504200 PMID 17558023 Entrez Gene SAT2 spermidine spermine N1 acetyltransferase 2 Jenstad M Quazi AZ Zilberter M Haglerod C Berghuis P Saddique N Goiny M Buntup D Davanger S S Haug FM Barnes CA McNaughton BL Ottersen OP Storm Mathisen J Harkany T Chaudhry FA May 2009 System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate Cereb Cortex 19 5 1092 106 doi 10 1093 cercor bhn151 PMID 18832333 Further reading EditBaek JH Liu YV McDonald KR et al 2008 Spermidine spermine N 1 acetyltransferase 1 binds to hypoxia inducible factor 1alpha HIF 1alpha and RACK1 and promotes ubiquitination and degradation of HIF 1alpha J Biol Chem 282 46 33358 66 doi 10 1074 jbc M705627200 PMID 17875644 Gornati R Chini V Rimoldi S et al 2007 Evaluation of SAT 1 SAT 2 and GalNAcT 1 mRNA in colon cancer by real time PCR Mol Cell Biochem 298 1 2 59 68 doi 10 1007 s11010 006 9350 0 hdl 11383 1672116 PMID 17119850 S2CID 29889795 Han BW Bingman CA Wesenberg GE Phillips GN 2006 Crystal structure of Homo sapiens thialysine Nepsilon acetyltransferase HsSSAT2 in complex with acetyl coenzyme A Proteins 64 1 288 93 doi 10 1002 prot 20967 PMID 16596569 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Barrios Rodiles M Brown KR Ozdamar B et al 2005 High throughput mapping of a dynamic signaling network in mammalian cells Science 307 5715 1621 5 Bibcode 2005Sci 307 1621B doi 10 1126 science 1105776 PMID 15761153 S2CID 39457788 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Chen Y Vujcic S Liang P et al 2003 Genomic identification and biochemical characterization of a second spermidine spermine N1 acetyltransferase Biochem J 373 Pt 3 661 7 doi 10 1042 BJ20030734 PMC 1223561 PMID 12803540 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SAT2 amp oldid 1171007237, wikipedia, wiki, book, books, library,

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