Hegde's research[7] investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases.[4]
His laboratory have discovered a widely conserved protein targeting pathway[8] needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Hegde's work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialised pathways to identify these wayward proteins and target them for destruction.[4]
^ abHegde, Ramanujan Shankar (1998). The regulation of protein translocation at the endoplasmic reticulum (PhD thesis). OCLC 50795524 – via ProQuest.
^ abc"Hegde, Dr Ramanujan S.". Who's Who. A & C Black. 2022. doi:10.1093/ww/9780199540884.013.U287290. (Subscription or UK public library membership required.)
^ abcSedwick, Caitlin (2010). "Ramanujan Hegde: The prion puzzle and protein translocation". The Journal of Cell Biology. 191 (7): 1222–1223. doi:10.1083/jcb.1917pi. PMC3010069. PMID 21187325.
^ abcdeAnon (2016). . London: royalsociety.org. Archived from the original on 29 April 2016. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --. Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
^Anon (2016). . Cambridge: University of Cambridge. Archived from the original on 13 April 2016.
^Anon (2016). "Hegde Lab: Protein biosynthesis & quality control". mrc-lmb.cam.ac.uk. Retrieved 22 December 2016.
^ abStefanovic, Sandra; Hegde, Ramanujan S. (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–1159. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.
^"Ramanujan Hegde publications in Google Scholar". Google Scholar.
^Hegde, R. S. (1998). "A Transmembrane Form of the Prion Protein in Neurodegenerative Disease". Science. 279 (5352): 827–834. Bibcode:1998Sci...279..827H. doi:10.1126/science.279.5352.827. PMID 9452375.
ramanujan, hegde, ramanujan, shankar, hegde, born, april, 1970, group, leader, medical, research, council, laboratory, molecular, biology, frshegde, 2016born, 1970, april, 1970, kumta, karnataka, india, alma, materuniversity, chicago, university, california, f. Ramanujan Shankar Hegde FRS 4 born 1 April 1970 2 is a group leader at the Medical Research Council MRC Laboratory of Molecular Biology LMB 5 6 Ramanujan HegdeFRSHegde in 2016Born 1970 04 01 1 April 1970 age 54 Kumta Karnataka India 2 Alma materUniversity of Chicago BA 3 University of California San Francisco MD PhD AwardsEMBO Member 2013 Scientific careerFieldsBiochemistryInstitutionsLaboratory of Molecular Biology University of Cambridge National Institutes of HealthThesisThe regulation of protein translocation at the endoplasmic reticulum 1998 Doctoral advisorVishwanath R Lingappa 1 Websitewww2 wbr mrc lmb wbr cam wbr ac wbr uk wbr groups wbr hegde wbr www2 wbr mrc lmb wbr cam wbr ac wbr uk wbr group leaders wbr h to m wbr ramanujan hegde wbr Contents 1 Education 2 Research and career 2 1 Awards and honours 3 ReferencesEducation editHegde was educated at the University of Chicago 3 where he was awarded a Bachelor of Arts degree 2 when and the University of California San Francisco where he was awarded a Doctor of Medicine MD degree in 1999 and PhD in 1998 for research on protein targeting and translocation at the endoplasmic reticulum supervised by Vishwanath R Lingappa 3 1 Research and career editHegde s research 7 investigates how proteins are localised correctly inside cells and how errors during protein maturation are recognised and disposed These processes are important because the accumulation of abnormal proteins is disruptive to cell function and underlies numerous diseases 4 His laboratory have discovered a widely conserved protein targeting pathway 8 needed by a subset of proteins to reach their correct membrane embedded destination Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion Hegde s work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration and that cells have specialised pathways to identify these wayward proteins and target them for destruction 4 As of 2016 update according to Google Scholar 9 his most cited research include papers published in Science 10 11 Nature 12 and Cell 8 His research has been funded by the Medical Research Council 13 nbsp Ramanujan Hegde in 2001 Awards and honours edit Hegde was awarded the R R Bensley award in Cell Biology in 2008 citation needed and elected a member of the European Molecular Biology Organisation EMBO in 2013 4 He was also elected a Fellow of the Royal Society FRS in 2016 4 References edit a b Hegde Ramanujan Shankar 1998 The regulation of protein translocation at the endoplasmic reticulum PhD thesis OCLC 50795524 via ProQuest a b c Hegde Dr Ramanujan S Who s Who A amp C Black 2022 doi 10 1093 ww 9780199540884 013 U287290 Subscription or UK public library membership required a b c Sedwick Caitlin 2010 Ramanujan Hegde The prion puzzle and protein translocation The Journal of Cell Biology 191 7 1222 1223 doi 10 1083 jcb 1917pi PMC 3010069 PMID 21187325 a b c d e Anon 2016 Dr Ramanujan Hegde FRS London royalsociety org Archived from the original on 29 April 2016 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies Archived from the original on 25 September 2015 Retrieved 9 March 2016 a href Template Cite web html title Template Cite web cite web a CS1 maint bot original URL status unknown link Anon 2016 Ramanujan Hegde MRC Laboratory of Molecular Biology Membrane protein biosynthesis and quality control Cambridge University of Cambridge Archived from the original on 13 April 2016 Anon 2016 Hegde Lab Protein biosynthesis amp quality control mrc lmb cam ac uk Retrieved 22 December 2016 Ramanujan Hegde publications from Europe PubMed Central a b Stefanovic Sandra Hegde Ramanujan S 2007 Identification of a targeting factor for posttranslational membrane protein insertion into the ER Cell 128 6 1147 1159 doi 10 1016 j cell 2007 01 036 PMID 17382883 S2CID 16802797 Ramanujan Hegde publications in Google Scholar Google Scholar Hegde R S 1998 A Transmembrane Form of the Prion Protein in Neurodegenerative Disease Science 279 5352 827 834 Bibcode 1998Sci 279 827H doi 10 1126 science 279 5352 827 PMID 9452375 Ramanujan S Hegde sciencemag org Hegde Ramanujan S Tremblay Patrick Groth Darlene DeArmond Stephen J Prusiner Stanley B Lingappa Vishwanath R 1999 Transmissible and genetic prion diseases share a common pathway of neurodegeneration Nature 402 6763 822 826 Bibcode 1999Natur 402 822H doi 10 1038 45574 PMID 10617204 S2CID 4354265 Anon 2016 UK Government Grants awarded to Ramanujan Hegde Swindon Research Councils UK Archived from the original on 4 May 2016 nbsp This article about a British scientist is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Ramanujan Hegde amp oldid 1170375619, wikipedia, wiki, book, books, library,
