Ribosomes, the organelles that catalyzeprotein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000008668 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chassin D, Bellet D, Koman A (Mar 1993). "The human homolog of ribosomal protein S18". Nucleic Acids Res. 21 (3): 745. doi:10.1093/nar/21.3.745. PMC309181. PMID 8441687.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Chan YL, Paz V, Wool IG (1991). "The primary structure of rat ribosomal protein S18". Biochem. Biophys. Res. Commun. 178 (3): 1212–8. doi:10.1016/0006-291X(91)91022-5. PMC335161. PMID 1872840.
Chassin D, Bénifla JL, Delattre C, et al. (1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts". Cancer Res. 54 (19): 5217–23. PMID 7923143.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Mishra-Gorur K, Singer HA, Castellot JJ (2002). "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II". J. Biol. Chem. 277 (37): 33537–40. doi:10.1074/jbc.C200342200. PMID 12145273.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Kusui K, Sasaki H, Adachi R, et al. (2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem. 262 (1–2): 187–93. doi:10.1023/B:MCBI.0000038234.35936.1c. PMID 15532723. S2CID 30534195.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC2253395. PMID 15883184.
External linksEdit
Overview of all the structural information available in the PDB for UniProt: P62269 (40S ribosomal protein S18) at the PDBe-KB.
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ribosomal, protein, protein, that, humans, encoded, rps18, gene, rps18available, structurespdbortholog, search, pdbe, rcsblist, codes4ug0, 4v6x, 5a2q, 5aj0, 4kzy, 3j7r, 4d61, 4kzx, 4d5l, 4v5z, 5flx, 4ujd, 3j7p, 4kzz, 4uje, 4ujcidentifiersaliasesrps18, d6s218e,. 40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene 5 6 7 RPS18Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UG0 4V6X 5A2Q 5AJ0 4KZY 3J7R 4D61 4KZX 4D5L 4V5Z 5FLX 4UJD 3J7P 4KZZ 4UJE 4UJCIdentifiersAliasesRPS18 D6S218E HKE3 KE 3 KE3 S18 ribosomal protein S18External IDsOMIM 180473 MGI 98146 HomoloGene 88764 GeneCards RPS18Gene location Human Chr Chromosome 6 human 1 Band6p21 32Start33 272 075 bp 1 End33 276 511 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 B1 17 17 98 cMStart34 170 973 bp 2 End34 174 975 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomencanal of the cervixlymph nodefallopian tubevaginaright uterine tubeleft uterine tubestromal cell of endometriumsubcutaneous adipose tissueprostateTop expressed inlipyolk sacmorulablastocystesophagusthymusneural tubethyroid glandproximal tubulespermatocyteMore reference expression dataBioGPSn aGene ontologyMolecular functionrRNA binding protein binding nucleic acid binding RNA binding structural constituent of ribosome protein kinase bindingCellular componentcytoplasm ribosome membrane focal adhesion intracellular anatomical structure small ribosomal subunit extracellular exosome nucleus nucleoplasm extracellular matrix cytosol cytosolic small ribosomal subunit postsynaptic density synapseBiological processviral transcription SRP dependent cotranslational protein targeting to membrane translational initiation nuclear transcribed mRNA catabolic process nonsense mediated decay protein biosynthesis ribosome biogenesis rRNA processingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez622220084EnsemblENSG00000226225ENSG00000096150ENSG00000231500ENSG00000235650ENSG00000223367ENSG00000227794ENSMUSG00000008668UniProtP62269P62270RefSeq mRNA NM 022551NM 011296NM 138946RefSeq protein NP 072045NP 035426Location UCSC Chr 6 33 27 33 28 MbChr 17 34 17 34 17 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseRibosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 40S subunit The protein belongs to the S13P family of ribosomal proteins It is located in the cytoplasm The gene product of the E coli ortholog ribosomal protein S13 is involved in the binding of fMet tRNA and thus in the initiation of translation This gene is an ortholog of mouse Ke3 As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 7 References Edit a b c ENSG00000096150 ENSG00000231500 ENSG00000235650 ENSG00000223367 ENSG00000227794 GRCh38 Ensembl release 89 ENSG00000226225 ENSG00000096150 ENSG00000231500 ENSG00000235650 ENSG00000223367 ENSG00000227794 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000008668 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chassin D Bellet D Koman A Mar 1993 The human homolog of ribosomal protein S18 Nucleic Acids Res 21 3 745 doi 10 1093 nar 21 3 745 PMC 309181 PMID 8441687 Kenmochi N Kawaguchi T Rozen S Davis E Goodman N Hudson TJ Tanaka T Page DC Aug 1998 A map of 75 human ribosomal protein genes Genome Res 8 5 509 23 doi 10 1101 gr 8 5 509 PMID 9582194 a b Entrez Gene RPS18 ribosomal protein S18 Further reading EditWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Chan YL Paz V Wool IG 1991 The primary structure of rat ribosomal protein S18 Biochem Biophys Res Commun 178 3 1212 8 doi 10 1016 0006 291X 91 91022 5 PMC 335161 PMID 1872840 Chassin D Benifla JL Delattre C et al 1994 Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts Cancer Res 54 19 5217 23 PMID 7923143 Vladimirov SN Ivanov AV Karpova GG et al 1996 Characterization of the human small ribosomal subunit proteins by N terminal and internal sequencing and mass spectrometry Eur J Biochem 239 1 144 9 doi 10 1111 j 1432 1033 1996 0144u x PMID 8706699 Andersen JS Lyon CE Fox AH et al 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Mishra Gorur K Singer HA Castellot JJ 2002 The S18 ribosomal protein is a putative substrate for Ca2 calmodulin activated protein kinase II J Biol Chem 277 37 33537 40 doi 10 1074 jbc C200342200 PMID 12145273 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Kusui K Sasaki H Adachi R et al 2005 Ribosomal protein S18 identified as a cofilin binding protein by using phage display library Mol Cell Biochem 262 1 2 187 93 doi 10 1023 B MCBI 0000038234 35936 1c PMID 15532723 S2CID 30534195 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Yu Y Ji H Doudna JA Leary JA 2005 Mass spectrometric analysis of the human 40S ribosomal subunit native and HCV IRES bound complexes Protein Sci 14 6 1438 46 doi 10 1110 ps 041293005 PMC 2253395 PMID 15883184 External links EditOverview of all the structural information available in the PDB for UniProt P62269 40S ribosomal protein S18 at the PDBe KB nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 40S ribosomal protein S18 amp oldid 1116940813, wikipedia, wiki, book, books, library,
