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Wikipedia

RANBP1

April 25, 2024

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.[5][6][7]

RANBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRANBP1, HTF9A, RAN binding protein 1
External IDsOMIM: 601180 MGI: 96269 HomoloGene: 21600 GeneCards: RANBP1
Orthologs
SpeciesHumanMouse
Entrez

5902

19385

Ensembl

ENSG00000099901

ENSMUSG00000005732

UniProt

P43487

P34022

RefSeq (mRNA)

NM_001278639
NM_001278640
NM_001278641
NM_002882

NM_011239

RefSeq (protein)

NP_001265568
NP_001265569
NP_001265570
NP_002873

NP_035369

Location (UCSC)Chr 22: 20.12 – 20.13 MbChr 16: 18.06 – 18.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.[7]

Interactions edit

RANBP1 has been shown to interact with XPO1,[8][9] KPNB1[9][10] and Ran.[9][11][12]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099901 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005732 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol Gen Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957. S2CID 24266692.
  6. ^ Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999). "A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export". J Cell Biol. 145 (4): 645–57. doi:10.1083/jcb.145.4.645. PMC 2133185. PMID 10330396.
  7. ^ a b "Entrez Gene: RANBP1 RAN binding protein 1".
  8. ^ Singh, B B; Patel H H; Roepman R; Schick D; Ferreira P A (December 1999). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1". J. Biol. Chem. 274 (52): 37370–8. doi:10.1074/jbc.274.52.37370. hdl:2066/120791. ISSN 0021-9258. PMID 10601307.
  9. ^ a b c Plafker, K; Macara I G (May 2000). "Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1". Mol. Cell. Biol. 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. ISSN 0270-7306. PMC 85643. PMID 10779340.
  10. ^ Yaseen, N R; Blobel G (September 1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358". J. Biol. Chem. 274 (37): 26493–502. doi:10.1074/jbc.274.37.26493. ISSN 0021-9258. PMID 10473610.
  11. ^ Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. ISSN 0270-7306. PMC 230439. PMID 7891706.
  12. ^ Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801.

Further reading edit

  • Bischoff FR, Krebber H, Smirnova E, et al. (1995). "Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1". EMBO J. 14 (4): 705–15. doi:10.1002/j.1460-2075.1995.tb07049.x. PMC 398135. PMID 7882974.
  • Ren M, Villamarin A, Shih A, et al. (1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. PMC 230439. PMID 7891706.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Coutavas E, Ren M, Oppenheim JD, et al. (1994). "Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4". Nature. 366 (6455): 585–7. Bibcode:1993Natur.366..585C. doi:10.1038/366585a0. PMID 8255297. S2CID 4302198.
  • Zolotukhin AS, Felber BK (1997). "Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1". J. Biol. Chem. 272 (17): 11356–60. doi:10.1074/jbc.272.17.11356. PMID 9111043.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Plafker K, Macara IG (2000). "Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1". Mol. Cell. Biol. 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. PMC 85643. PMID 10779340.
  • Steggerda SM, Paschal BM (2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. PMID 10811801.
  • Maynard TM, Haskell GT, Bhasin N, et al. (2002). "RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction". Mech. Dev. 111 (1–2): 177–80. doi:10.1016/S0925-4773(01)00616-5. PMID 11804793.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Di Fiore B, Ciciarello M, Mangiacasale R, et al. (2004). "Mammalian RanBP1 regulates centrosome cohesion during mitosis". J. Cell Sci. 116 (Pt 16): 3399–411. doi:10.1242/jcs.00624. PMID 12840069.
  • Seewald MJ, Kraemer A, Farkasovsky M, et al. (2003). "Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction?". Mol. Cell. Biol. 23 (22): 8124–36. doi:10.1128/MCB.23.22.8124-8136.2003. PMC 262373. PMID 14585972.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bohlson SS, Zhang M, Ortiz CE, Tenner AJ (2005). "CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis". J. Leukoc. Biol. 77 (1): 80–9. doi:10.1189/jlb.0504305. PMID 15459234. S2CID 3219168.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
  • Takeda E, Hieda M, Katahira J, Yoneda Y (2006). "Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1". Cell Struct. Funct. 30 (2): 69–80. doi:10.1247/csf.30.69. PMID 16428860.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

April 25, 2024
ranbp1, specific, binding, protein, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1k5d, 1k5gidentifiersaliases, htf9a, binding, protein, 1external, idsomim, 601180, 96269, homologene, 21600, genecards, gene. Ran specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene 5 6 7 RANBP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1K5D 1K5GIdentifiersAliasesRANBP1 HTF9A RAN binding protein 1External IDsOMIM 601180 MGI 96269 HomoloGene 21600 GeneCards RANBP1Gene location Human Chr Chromosome 22 human 1 Band22q11 21Start20 115 938 bp 1 End20 127 355 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 A3 16 11 3 cMStart18 057 648 bp 2 End18 066 596 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceprefrontal cortexcerebellar hemisphereleft uterine tuberight adrenal glandappendixthymusBrodmann area 9right lobe of liverskin of abdomenTop expressed inyolk sacneural tubemesencephalonganglionic eminencelensuterusthymusolfactory bulbplacentastomachMore reference expression dataBioGPSn aGene ontologyMolecular functionGTPase activator activity GDP dissociation inhibitor activity protein binding cadherin bindingCellular componentcytoplasm nuclear envelope nucleus centrosome cytosol nuclear poreBiological processpositive regulation of GTPase activity intracellular transport viral process signal transduction ubiquitin dependent protein catabolic process regulation of catalytic activity protein import into nucleus spindle organization positive regulation of mitotic centrosome separation RNA export from nucleus G1 S transition of mitotic cell cycleSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez590219385EnsemblENSG00000099901ENSMUSG00000005732UniProtP43487P34022RefSeq mRNA NM 001278639NM 001278640NM 001278641NM 002882NM 011239RefSeq protein NP 001265568NP 001265569NP 001265570NP 002873NP 035369Location UCSC Chr 22 20 12 20 13 MbChr 16 18 06 18 07 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Ran TC4 binding protein RanBP1 interacts specifically with GTP charged RAN RANBP1 encodes a 23 kD protein that binds to RAN complexed with GTP but not GDP RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase activating protein RANGAP1 The RANBP1 cDNA encodes a 201 amino acid protein that is 92 similar to its mouse homolog In both mammalian cells and in yeast RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1 stimulated guanine nucleotide release from RAN 7 Interactions editRANBP1 has been shown to interact with XPO1 8 9 KPNB1 9 10 and Ran 9 11 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000099901 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005732 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hayashi N Yokoyama N Seki T Azuma Y Ohba T Nishimoto T August 1995 RanBP1 a Ras like nuclear G protein binding to Ran TC4 inhibits RCC1 via Ran TC4 Mol Gen Genet 247 6 661 9 doi 10 1007 BF00290397 PMID 7616957 S2CID 24266692 Kehlenbach RH Dickmanns A Kehlenbach A Guan T Gerace L July 1999 A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export J Cell Biol 145 4 645 57 doi 10 1083 jcb 145 4 645 PMC 2133185 PMID 10330396 a b Entrez Gene RANBP1 RAN binding protein 1 Singh B B Patel H H Roepman R Schick D Ferreira P A December 1999 The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor exportin 1 J Biol Chem 274 52 37370 8 doi 10 1074 jbc 274 52 37370 hdl 2066 120791 ISSN 0021 9258 PMID 10601307 a b c Plafker K Macara I G May 2000 Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1 Mol Cell Biol 20 10 3510 21 doi 10 1128 MCB 20 10 3510 3521 2000 ISSN 0270 7306 PMC 85643 PMID 10779340 Yaseen N R Blobel G September 1999 GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358 J Biol Chem 274 37 26493 502 doi 10 1074 jbc 274 37 26493 ISSN 0021 9258 PMID 10473610 Ren M Villamarin A Shih A Coutavas E Moore M S LoCurcio M Clarke V Oppenheim J D D Eustachio P Rush M G April 1995 Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing Mol Cell Biol 15 4 2117 24 doi 10 1128 MCB 15 4 2117 ISSN 0270 7306 PMC 230439 PMID 7891706 Steggerda S M Paschal B M July 2000 The mammalian Mog1 protein is a guanine nucleotide release factor for Ran J Biol Chem 275 30 23175 80 doi 10 1074 jbc C000252200 ISSN 0021 9258 PMID 10811801 Further reading editBischoff FR Krebber H Smirnova E et al 1995 Co activation of RanGTPase and inhibition of GTP dissociation by Ran GTP binding protein RanBP1 EMBO J 14 4 705 15 doi 10 1002 j 1460 2075 1995 tb07049 x PMC 398135 PMID 7882974 Ren M Villamarin A Shih A et al 1995 Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing Mol Cell Biol 15 4 2117 24 doi 10 1128 MCB 15 4 2117 PMC 230439 PMID 7891706 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Coutavas E Ren M Oppenheim JD et al 1994 Characterization of proteins that interact with the cell cycle regulatory protein Ran TC4 Nature 366 6455 585 7 Bibcode 1993Natur 366 585C doi 10 1038 366585a0 PMID 8255297 S2CID 4302198 Zolotukhin AS Felber BK 1997 Mutations in the nuclear export signal of human ran binding protein RanBP1 block the Rev mediated posttranscriptional regulation of human immunodeficiency virus type 1 J Biol Chem 272 17 11356 60 doi 10 1074 jbc 272 17 11356 PMID 9111043 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Plafker K Macara IG 2000 Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1 Mol Cell Biol 20 10 3510 21 doi 10 1128 MCB 20 10 3510 3521 2000 PMC 85643 PMID 10779340 Steggerda SM Paschal BM 2000 The mammalian Mog1 protein is a guanine nucleotide release factor for Ran J Biol Chem 275 30 23175 80 doi 10 1074 jbc C000252200 PMID 10811801 Maynard TM Haskell GT Bhasin N et al 2002 RanBP1 a velocardiofacial DiGeorge syndrome candidate gene is expressed at sites of mesenchymal epithelial induction Mech Dev 111 1 2 177 80 doi 10 1016 S0925 4773 01 00616 5 PMID 11804793 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Di Fiore B Ciciarello M Mangiacasale R et al 2004 Mammalian RanBP1 regulates centrosome cohesion during mitosis J Cell Sci 116 Pt 16 3399 411 doi 10 1242 jcs 00624 PMID 12840069 Seewald MJ Kraemer A Farkasovsky M et al 2003 Biochemical Characterization of the Ran RanBP1 RanGAP System Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran RanGAP GTPase Reaction Mol Cell Biol 23 22 8124 36 doi 10 1128 MCB 23 22 8124 8136 2003 PMC 262373 PMID 14585972 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Bohlson SS Zhang M Ortiz CE Tenner AJ 2005 CD93 interacts with the PDZ domain containing adaptor protein GIPC implications in the modulation of phagocytosis J Leukoc Biol 77 1 80 9 doi 10 1189 jlb 0504305 PMID 15459234 S2CID 3219168 Collins JE Wright CL Edwards CA et al 2005 A genome annotation driven approach to cloning the human ORFeome Genome Biol 5 10 R84 doi 10 1186 gb 2004 5 10 r84 PMC 545604 PMID 15461802 Bruneel A Labas V Mailloux A et al 2006 Proteomics of human umbilical vein endothelial cells applied to etoposide induced apoptosis Proteomics 5 15 3876 84 doi 10 1002 pmic 200401239 PMID 16130169 S2CID 26007149 Takeda E Hieda M Katahira J Yoneda Y 2006 Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1 Cell Struct Funct 30 2 69 80 doi 10 1247 csf 30 69 PMID 16428860 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Retrieved from https en wikipedia org w index php title RANBP1 amp oldid 1193733480, wikipedia, wiki, book, books, library,

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